中华皮肤科杂志 ›› 2019, Vol. 52 ›› Issue (11): 852-855.doi: 10.35541/cjd.20180744
张元文 潘文东
收稿日期:
2018-09-07
修回日期:
2018-11-15
发布日期:
2019-11-04
通讯作者:
潘文东
E-mail:alexzyw983@hotmail.com
Zhang Yuanwen, Pan Wendong
Received:
2018-09-07
Revised:
2018-11-15
Published:
2019-11-04
Contact:
Pan Wendong
E-mail:alexzyw983@hotmail.com
摘要: 【摘要】 面部毛孔粗大是一个常见的皮肤问题,其发生主要与皮脂分泌旺盛、皮肤老化(皮肤弹性松弛)以及毛囊体积增大等因素有关,目前的治疗主要针对这些因素。本文回顾总结了目前常用的治疗方法,包括口服抗雄激素药、局部外用维A酸类药物、化学剥脱术以及激光、射频、聚焦超声等光电治疗,而光电设备的不断发展提供了更新、更可靠的选择。
张元文 潘文东. 面部毛孔粗大的治疗进展[J]. 中华皮肤科杂志, 2019, 52(11): 852-855.doi:10.35541/cjd.20180744
Zhang Yuanwen, Pan Wendong . Treatment of enlarged facial pores[J]. Chinese Journal of Dermatology, 2019, 52(11): 852-855.doi:10.35541/cjd.20180744
[1] | Sugiyama⁃Nakagiri Y, Sugata K, Iwamura M, et al. Age⁃related changes in the epidermal architecture around facial pores[J]. J Dermatol Sci, 2008,50(2):151⁃154. doi: 10.1016/j.jdermsci.2007. 11.014. |
[2] | Uhoda E, Piérard⁃Franchimont C, Petit L, et al. The conundrum of skin pores in dermocosmetology[J]. Dermatology, 2005,210(1):3⁃7. doi: 10.1159/000081474. |
[3] | Mizukoshi K, Takahashi K. Analysis of the skin surface and inner structure around pores on the face[J]. Skin Res Technol, 2014,20(1):23⁃29. doi: 10.1111/srt.12078. |
[4] | Kim BY, Choi JW, Park KC, et al. Sebum, acne, skin elasticity, and gender difference ⁃ which is the major influencing factor for facial pores?[J]. Skin Res Technol, 2013,19(1):e45⁃e53. doi: 10.1111/j.1600⁃0846.2011.00605.x. |
[5] | Ning Y, Qing Z, Qing W, et al. Evaluating photographic scales of facial pores and diagnostic agreement of tests using latent class models[J]. J Cosmet Laser Ther, 2017,19(1):64⁃67. doi: 10. 1080/14764172.2016.1247969. |
[6] | Sun JY, Kim SW, Lee SH, et al. Automatic facial pore analysis system using multi⁃scale pore detection[J]. Skin Res Technol, 2017,23(3):354⁃362. doi: 10.1111/srt.12342. |
[7] | Jang SI, Kim EJ, Lee HK. A method of evaluating facial pores using optical 2D images and analysis of age⁃dependent changes in facial pores in Koreans[J]. Skin Res Technol, 2018,24(2):304⁃308. doi: 10.1111/srt.12430. |
[8] | Linming F, Wei H, Anqi L, et al. Comparison of two skin imaging analysis instruments: the VISIA® from Canfield vs the ANTERA 3D® CS from Miravex[J]. Skin Res Technol, 2018,24(1):3⁃8. doi: 10.1111/srt.12381. |
[9] | Messaraa C, Metois A, Walsh M, et al. Antera 3D capabilities for pore measurements[J]. Skin Res Technol, 2018,24(4):606⁃613. doi: 10.1111/srt.12472. |
[10] | Lee SJ, Seok J, Jeong SY, et al. Facial pores: definition, causes, and treatment options[J]. Dermatol Surg, 2016,42(3):277⁃285. doi: 10.1097/DSS.0000000000000657. |
[11] | Flament F, Francois G, Qiu H, et al. Facial skin pores: a multiethnic study[J]. Clin Cosmet Investig Dermatol, 2015,8:85⁃93. doi: 10.2147/CCID.S74401. |
[12] | Flament F, Bourokba N, Nouveau S, et al. A severe chronic outdoor urban pollution alters some facial aging signs in Chinese women. A tale of two cities[J]. Int J Cosmet Sci, 2018,40(5):467⁃481. doi: 10.1111/ics.12487. |
[13] | Roh M, Han M, Kim D, et al. Sebum output as a factor contributing to the size of facial pores[J]. Br J Dermatol, 2006,155(5):890⁃894. doi: 10.1111/j.1365⁃2133.2006.07465.x. |
[14] | Uitto J. The role of elastin and collagen in cutaneous aging: intrinsic aging versus photoexposure[J]. J Drugs Dermatol, 2008,7(2 Suppl):s12⁃16. |
[15] | Zheng Q, Chen S, Chen Y, et al. Investigation of age⁃related decline of microfibril⁃associated glycoprotein⁃1 in human skin through immunohistochemistry study[J]. Clin Cosmet Investig Dermatol, 2013,6:317⁃323. doi: 10.2147/CCID.S51958. |
[16] | Jung HJ, Ahn JY, Lee JI, et al. Analysis of the number of enlarged pores according to site, age, and sex[J]. Skin Res Technol, 2018,24(3):367⁃370. doi: 10.1111/srt.12438. |
[17] | Elliott K, Stephenson TJ, Messenger AG. Differences in hair follicle dermal papilla volume are due to extracellular matrix volume and cell number: implications for the control of hair follicle size and androgen responses[J]. J Invest Dermatol, 1999,113(6):873⁃877. doi: 10.1046/j.1523⁃1747.1999.00797.x. |
[18] | Barros B, Thiboutot D. Hormonal therapies for acne[J]. Clin Dermatol, 2017,35(2):168⁃172. doi: 10.1016/j.clindermatol.2016. 10.009. |
[19] | Kerscher M, Reuther T, Bayrhammer J, et al. Effects of an oral contraceptive containing chlormadinone and ethinylestradiol on acne⁃prone skin of women of different age groups: an open⁃label, single⁃centre, phase IV study[J]. Clin Drug Investig, 2008,28(11):703⁃711. doi: 10.2165/00044011⁃200828110⁃00004. |
[20] | Mukherjee S, Date A, Patravale V, et al. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety[J]. Clin Interv Aging, 2006,1(4):327⁃348. |
[21] | Zouboulis CC. Isotretinoin revisited: pluripotent effects on human sebaceous gland cells[J]. J Invest Dermatol, 2006,126(10):2154⁃2156. doi: 10.1038/sj.jid.5700418. |
[22] | Bouloc A, Vergnanini AL, Issa MC. A double⁃blind randomized study comparing the association of Retinol and LR2412 with tretinoin 0.025% in photoaged skin[J]. J Cosmet Dermatol, 2015,14(1):40⁃46. doi: 10.1111/jocd.12131. |
[23] | Kim WS. Efficacy and safety of a new superficial chemical peel using alpha⁃hydroxy acid, vitamin C and oxygen for melasma[J]. J Cosmet Laser Ther, 2013,15(1):21⁃24. doi: 10.3109/14764172.2012.748199. |
[24] | Kakudo N, Kushida S, Tanaka N, et al. A novel method to measure conspicuous facial pores using computer analysis of digital⁃camera⁃captured images: the effect of glycolic acid chemical peeling[J]. Skin Res Technol, 2011,17(4):427⁃433. doi: 10.1111/j.1600⁃0846.2011.00514.x. |
[25] | Sigler ML, Stephens TJ. Assessment of the safety and efficacy of topical copper chlorophyllin in women with photodamaged facial skin[J]. J Drugs Dermatol, 2015,14(4):401⁃404. |
[26] | McCook JP, Dorogi PL, Vasily DB, et al. In vitro inhibition of hyaluronidase by sodium copper chlorophyllin complex and chlorophyllin analogs[J]. Clin Cosmet Investig Dermatol, 2015,8:443⁃448. doi: 10.2147/CCID.S86863. |
[27] | Stephens TJ, McCook JP, Herndon JH Jr. Pilot study of topical copper chlorophyllin complex in subjects with facial acne and large pores[J]. J Drugs Dermatol, 2015,14(6):589⁃592. |
[28] | Alexiades M. Jasmonates and tetrahydrojasmonic acid: a novel class of anti⁃aging molecules[J]. J Drugs Dermatol, 2016,15(2):206⁃207. |
[29] | Tran C, Michelet JF, Simonetti L, et al. In vitro and in vivo studies with tetra⁃hydro⁃jasmonic acid (LR2412) reveal its potential to correct signs of skin ageing[J]. J Eur Acad Dermatol Venereol, 2014,28(4):415⁃423. doi: 10.1111/jdv.12113. |
[30] | Alexiades M. Clinical assessment of a novel jasmonate cosmeceutical, LR2412⁃Cx, for the treatment of skin aging[J]. J Drugs Dermatol, 2016,15(2):209⁃215. |
[31] | Schmults CD, Phelps R, Goldberg DJ. Nonablative facial remodeling: erythema reduction and histologic evidence of new collagen formation using a 300⁃microsecond 1064⁃nm Nd:YAG laser[J]. Arch Dermatol, 2004,140(11):1373⁃1376. doi: 10. 1001/archderm.140.11.1373. |
[32] | Suh DH, Chang KY, Lee SJ, et al. Treatment of dilated pores with 1 410⁃nm fractional erbium⁃doped fiber laser[J]. Lasers Med Sci, 2015,30(3):1135⁃1139. doi: 10.1007/s10103⁃015⁃1719⁃4. |
[33] | Yu W, Zhu J, Ma G, et al. Randomized split⁃face, controlled comparison of treatment with 1 565⁃nm nonablative fractional laser for enlarged facial pores[J]. Br J Dermatol, 2018,178(4):e271⁃e272. doi: 10.1111/bjd.16115. |
[34] | Kwon HH, Choi SC, Lee WY, et al. Clinical and histological evaluations of enlarged facial skin pores after low energy level treatments with fractional carbon dioxide laser in Korean patients[J]. Dermatol Surg, 2018,44(3):405⁃412. doi: 10.1097/DSS.000 0000000001313. |
[35] | Zhang M, Fang J, Wu Q, et al. A prospective study of the safety and efficacy of a microneedle fractional radiofrequency system for global facial photoaging in Chinese patients[J]. Dermatol Surg, 2018,44(7):964⁃970. doi: 10.1097/DSS.000000000000 1469. |
[36] | Elawar A, Dahan S. Non⁃insulated fractional microneedle radiofrequency treatment with smooth motor insertion for reduction of depressed acne scars, pore size, and skin texture improvement: a preliminary study[J]. J Clin Aesthet Dermatol, 2018,11(8):41⁃44. |
[37] | Lu PH, Yang CH, Chang YC. Quantitative analysis of face and neck skin tightening by microfocused ultrasound with visualization in Asians[J]. Dermatol Surg, 2017,43(11):1332⁃1338. doi: 10.1097/DSS.0000000000001181. |
[38] | Lee HJ, Lee KR, Park JY, et al. The efficacy and safety of intense focused ultrasound in the treatment of enlarged facial pores in Asian skin[J]. J Dermatolog Treat, 2015,26(1):73⁃77. doi: 10.3109/09546634.2013.868862. |
[39] | Knight JM, Kautz G. Sequential facial skin rejuvenation with intense pulsed light and non⁃ablative fractionated laser resurfacing in fitzpatrick skin type II⁃IV patients: a prospective multicenter analysis[J]. Lasers Surg Med, 2019,51(2):141⁃149. doi: 10.1002/lsm.23007. |
[40] | Mei XL, Wang L. Ablative fractional carbon dioxide laser combined with intense pulsed light for the treatment of photoaging skin in Chinese population: a split⁃face study[J]. Medicine (Baltimore), 2018,97(3):e9494. doi: 10.1097/MD.0000 000000009494. |
[41] | Lin J, Jing L, Zhu H, et al. Fundamental research on the action mechanism of the 800 nm semiconductor laser on skin blackheads and coarse pores[J]. Exp Ther Med, 2017,13(1):235⁃241. doi: 10.3892/etm.2016.3937. |
[42] | Rose AE, Goldberg DJ. Safety and efficacy of intradermal injection of botulinum toxin for the treatment of oily skin[J]. Dermatol Surg, 2013,39(3 Pt 1):443⁃448. doi: 10.1111/dsu. 12097. |
[43] | Sapra P, Demay S, Sapra S, et al. A single⁃blind, split⁃face, randomized, pilot study comparing the effects of intradermal and intramuscular injection of two commercially available botulinum toxin a formulas to reduce signs of facial aging[J]. J Clin Aesthet Dermatol, 2017,10(2):34⁃44. |
[44] | Cheng HY, Chen YX, Wang MF, et al. Evaluation of changes in skin biophysical parameters and appearance after pneumatic injections of non⁃cross⁃linked hyaluronic acid in the face[J]. J Cosmet Laser Ther, 2018,20(7⁃8):454⁃461. doi: 10.1080/1476 4172.2018.1427868. |
[45] | Qian W, Zhang YK, Hou Y, et al. Effect analysis of intradermal hyaluronic acid injection to treat enlarged facial pores[J]. J Cosmet Dermatol, 2018,17(4):596⁃599. doi: 10.1111/jocd.12385. |
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