원저

비용조직에서 Galectin-3 발현에 대한 면역조직학적 연구

이재훈1, 이상헌1, 정정래1, 이정헌1, 윤기중2,*
Jae Hoon Lee1, Sang Heon Lee1, Jung Rae Jeong1, Jung Hun Lee1, Ki Jung Yun2,*
Author Information & Copyright
1원광대학교 의과대학 이비인후과학교실
2병리학교실
1Department of Otolaryngology, Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, Iksan, Korea
2Pathology, Institute of Wonkwang Medical Science, College of Medicine, Wonkwang University, Iksan, Korea
*교신저자: 이재훈, 570-711 전북 익산시 신용동 344-2 원광대학교 의과대학 이비인후과학교실 전화: (063) 850-1310·전송: (063) 841-6556 E-mail: coolnose@wonnms.wonkwang.ac.kr

© Copyright 2007 The Busan, Ulsan, Gyeoungnam Branch of Korean Society of Otolaryngology-Head and Neck Surgery. This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Received: Aug 15, 2007; Accepted: Sep 28, 2007

Published Online: May 31, 2020

ABSTRACT

Background and Objectives: Nasal polyp is benign growth processes in the nasal and sinus mucosa. Galectin-3 is a beta-galactoside binding protein, of which the major function is not fully elucidated. Galectin-3 expression can be linked to the benign growth activity of nasal polyps due to an anti-apoptotic effector activity. To illustrate the role of the galectin-3 in the nasal polyp, we investigated the expressive pattern of the galectin-3 in nasal polyp and the influence of corticosteroid on its expression. Materials and Methods: The study materials were 30 specimens of nasal polyp (steroid user: 14 cases, steroid non-user: 16 cases) taken from 30 patients during endoscopic sinus surgery and 10 cases of normal nasal mucosa of the inferior turbinate as control. The galectin-3 expression was assessed by immunohistochemical staining. Results: The galectin-3 expression in the surface epithelium, lamina propria and glands was markedly higher in nasal polyps than in turbinates. There was significantly different in the expression of galectin-3 between the steroid user group and the non-user group of nasal polyps. The galectin-3 expression in the surface epithelium and glands was markedly lower in steroid user group than in non-user group. Conclusion: Galectin-3 may be associated with growth of nasal polyp. Oral corticosteroids may exert a beneficial effect by significantly reducing the levels of galectin-3 in nasal polyp. (J Clinical Otolaryngol 2007;18:190–194)

Keywords: 비용; Galectin–3
Keywords: Nasal polyp; Galectin-3