Next Article in Journal
Robust Classification and Detection of Big Medical Data Using Advanced Parallel K-Means Clustering, YOLOv4, and Logistic Regression
Next Article in Special Issue
The Role of Yeasts in Human Health: A Review
Previous Article in Journal
Greener Grass: The Modern History of Epithelial Stem Cell Innovation
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
Life
Volume 13
Issue 3
10.3390/life13030689
life-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021

by
Bassey E. Ekeng
1,2,*,
Asa E. Itam-Eyo
3,
Iriagbonse I. Osaigbovo
1,4,
Adilia Warris
5,
Rita O. Oladele
1,6,
Felix Bongomin
7 and
David W. Denning
8
1
Medical Mycology Society of Nigeria, Lagos 101017, Nigeria
2
Department of Medical Microbiology and Parasitology, University of Calabar Teaching Hospital, Calabar 540271, Nigeria
3
Department of Internal Medicine, University of Calabar Teaching Hospital, Calabar 540271, Nigeria
4
Department of Medical Microbiology, School of Medicine, College of Medical Sciences, University of Benin, Benin City 300213, Nigeria
5
Medical Research Council Centre for Medical Mycology, University of Exeter, Exeter EX4 4QD, UK
6
Department of Medical Microbiology and Parasitology, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Lagos 101017, Nigeria
7
Department of Medical Microbiology & Immunology, Faculty of Medicine, Gulu University, Gulu P.O. Box 166, Uganda
8
Manchester Fungal Infection Group, Faculty of Biology, Medicine and Health, The University of Manchester, Manchester Academic Health Science Centre, Manchester M13 9WL, UK
*
Author to whom correspondence should be addressed.
Life 2023, 13(3), 689; https://doi.org/10.3390/life13030689
Submission received: 23 January 2023 / Revised: 15 February 2023 / Accepted: 27 February 2023 / Published: 3 March 2023
(This article belongs to the Special Issue Fungal Disease Epidemiology: Current State and Future Prospects)
Browse Figure
Versions Notes

Abstract

:
Gastrointestinal histoplasmosis (GIH) is infrequently described in people without underlying HIV infection. We aimed to compare the clinical presentation of GIH in people with and without HIV infection. We conducted a literature search of published cases of GIH from 2001–2021 and found 212 cases. Of these, 142 (67.0%) were male, and 124 (58.5%) had HIV infection. Most cases were from North America (n = 88, 41.5%) and South America (n = 79, 37.3%). Of the 212 cases, 123 (58.0%) were included in both clinical and pathological analyses. The remainder were excluded as details about clinical and pathological findings were not available. Of the 123 cases, 41 had HIV infection while 82 were without HIV infection. The diagnosis was predominantly by histopathology (n = 109, 88.6%). A significant proportion of people with HIV infection had abdominal pain as the most predominant symptom of GIH compared to those without HIV infection (65.9% versus 41.9%, p < 0.05). The colon was the most affected site with a slightly higher proportion in those with HIV infection compared with cases without HIV infection (46.3% versus 42.7%). The commonest pathologic findings were caecal and ileal ulcers. Caecal ulcers were significantly more frequent in cases with HIV infection compared to those without HIV (32.1% versus 7.1%, p < 0.05). Despite being more common in people with HIV infection, GIH also affects people without HIV infection with similar clinical presentations.

1. Introduction

Histoplasmosis is a serious fungal disease that occurs worldwide; endemics have occurred in the Ohio and Mississippi river valley regions of the USA and Central and South America including Guatemala, Guiana Shield, Dominican Republic, Trinidad and Tobago and Brazil [1,2]. Increasing cases are also now being reported in West Africa, Central Africa, East Africa, Southern Africa and Southeast Asia [1,3]. Histoplasmosis is primarily acquired via inhalation of Histoplasma microconidia aerosolised following disruption of soil rich in guano. Caving, farming, hunting, excavation and travel to endemic regions are additional risk factors [1,2]. The spectrum of clinical manifestation ranges from asymptomatic infection, acute pulmonary disease, chronic pulmonary disease and disseminated histoplasmosis (DH) [1,2]. DH is commonly seen in the immunocompromised, especially in people living with HIV/AIDS and others including organ transplant recipients, malignancies, chemotherapy, immunosuppressive agents, prolonged steroid usage and excessive environmental exposure [2,4,5,6,7].
Gastrointestinal histoplasmosis (GIH) is a rarely reported clinical form of DH. The most common sites of involvement are the colon and ileum [8,9]. Affinity for those areas of the gastrointestinal tract is attributed to the abundance of lymphoid tissues [8,9]. In an autopsy series, Histoplasma was identified in the gastrointestinal tract in 70% of DH cases [9]. However, symptomatic disease leading to clinical diagnosis of GIH was found in only 3–12% of patients [9]. This discordance makes it highly suspicious that GIH may be underdiagnosed due to its non-specific symptoms [9]. Besides occurring as a sequela of DH, GIH can also develop as a localised disease entity [9]. Previous reviews on GIH focused mainly on people living with HIV [8,10,11]. However, there is a paucity of studies describing the clinical presentation of GIH in people without HIV infection despite significant data showing the occurrence of GIH in immunocompetent hosts [9]. In this review, we aimed at highlighting the clinical features of GIH with a focus to compare clinical presentation and complications in people with and without HIV infection.

2. Materials and Methods

We conducted a literature search using PubMed, Google scholar and African Journal Online to identify case reports and case series on GIH from ‘1 January 2001–31 December 2021’ (BEE). The search term was “gastrointestinal histoplasmosis” OR “gastrointestinal AND “histoplasmosis”. References in all relevant papers were also reviewed for additional publications on case reports regarding the topic that may not have been published in the searched databases. Individual cases and case series of GIH published before 2001 were excluded. Case reports or case series without patients’ country of origin or location of disease were excluded. No language restrictions were applied. Diagnosis of histoplasmosis was defined as the identification of H. capsulatum var capsulatum or H. capsulatum var duboisii via histopathological examination of tissue samples or culture or molecular methods and/or positive Histoplasma antigen detection or antibody detection. A second author (AEI) independently repeated the entire search and selection process to prevent selection bias. Any inconsistencies were discussed until a consensus was reached as to what studies should be included. Data extracted from each case report included: gender, age, clinical features, pathological findings, complications, HIV infection status, immunosuppression, investigation/diagnostic measures, treatment and outcomes. A comparative analysis of the clinical features and pathological findings of GIH between cases with and without HIV infection was performed using Fisher’s exact test. A p-value of <0.05 was considered statistically significant.

3. Results

We identified 212 cases of GIH across the world’s regions, as summarised in Table 1 and Figure 1. Of the 212 cases,142 (67.0%) were male. Only one (0.5%) case was documented in a child. In total, 124 (58.5%) cases had underlying HIV infection. GIH was predominant amongst people living with HIV from Central and South America, while more cases were seen in HIV-negative patients in North America, Asia, Europe and Australia (Table 1). Of the 88 cases without HIV infection, 15 (17.0%) were post-transplant patients on immunosuppressants, 31 (35.2%) were on immunosuppressants for various disease conditions, three (3.4%) were diagnosed with an immunodeficiency syndrome, one suffered from diabetes mellitus (0.5%) and the remaining 38 (43.1%) were immunocompetent.
Analysis of the 123 well-documented cases showed the clinical presentation of GIH was often non-specific and mimicked several other gastrointestinal conditions and pathologies, including abdominal tuberculosis (n = 3, 2.4%) [85,96,102], GIH and TB coinfection was reported in four [3.3%] cases [78,87,96,98], inflammatory bowel disease (n = 9, 7.3%) [21,33,40,52,69,75,89,105,107], intestinal obstruction (n = 15, 12.2%) [15,21,39,50,57,64,71,77,81,89,95,102,103,104,117], abdominal malignancy (n = 9, 7.3%) [14,16,31,80,83,101,102,108,112], GI bleeding (n = 29, 23.6%) [17,18,25,26,27,29,30,31,33,37,41,44,53,56,59,63,70,71,81,84,94,102,103,105,107,110,116,119], hepatitis (n = 19, 15.4%), cholecystitis (n = 7, 5.7%) [22,24,34,47,54,56,61,67,68,72,73,76,83,86,97,101,109,114,118]), acute pancreatitis (n = 3, 2.4%) [20,65,75,77] and acute abdomen (n = 4, 3.1%) [70,74,99,112]. Oesophageal involvement was rarely reported and presented mostly as ulcers or as obstruction of the oesophagus due to oesophageal polyps or mediastinal lymph nodes (n = 13, 10.6%) [13,20,40,42,56,58,77,80,100,104,116,121].
Comparing the clinical presentation between people living with HIV and people without underlying HIV infection, a significant proportion of people with HIV infection had abdominal pain as the most predominant symptom of GIH (65.9% versus 41.9%, p = 0.01), Table 2. The colon was the most affected site with a slightly higher proportion in those with HIV infection compared with cases without HIV infection (46.3% versus 42.7%), Table 2. The mode of diagnosis was predominantly by histopathology (n = 109, 88.6%) of biopsied specimens/tissues, as shown in Table 2. Some of the case reports highlighted endoscopy findings and are summarised in Table 3. The commonest pathological findings were caecal and ileal ulcers. Caecal ulcers were significantly higher (p= 0.008) in cases with HIV infection, Table 3. Cases without HIV infection suffered more often from complications compared with cases with HIV infection, Table 2.
Our review also identified four asymptomatic cases of GIH in the absence of respiratory tract involvement, as evidenced by normal chest imaging findings [16,32,58,60]. The diagnosis was made based on incidental findings during screening colonoscopy for polyps when ulcerated mucosa [60], ulcerated masses in the ascending colon [58,60] and the entire colon [16,32] were found. Individuals affected were HIV-negative, but immunocompromised, including hepatitis C infection [58], post-liver transplant on immunosuppressive agents [16,32] and psoriatic arthritis on treatment with methotrexate and infliximab [60]. Further evaluation of colonoscopy findings through biopsy of an affected area [16,32,58,60], Histoplasma antigen in the urine and antibody to Histoplasma antigen [16] further supported the diagnosis of GIH. Treatment with itraconazole resulted in the resolution of the disease [16,32,58,60]. In one patient, a right hemicolectomy was performed as malignancy was suspected [60] before the diagnosis of GIH was made.
Treatment and outcomes were specified in 119 cases. Of the 119,111 (93.3%) had favourable outcomes while eight (6.7%) cases were fatal. Of the 111,35 (31.5%) had HIV infection and of the eight fatal cases, six (75.0%) had HIV infection. The association between positive HIV status and fatal outcomes was statistically significant (p= 0.01). Treatment was predominantly with the use of amphotericin B in combination with an azole (n = 70), followed by azole monotherapy (n = 29). Outcomes with the use of combination therapy were favourable in all the cases and 96.6% (28/29) with azole monotherapy (Table 4).

4. Discussion

As is known for DH, GIH predominantly occurs in the immunocompromised. However, it can also be found in immunocompetent individuals. GIH mimics several gastrointestinal conditions and is common in many parts of the world, including Africa. It is thus not surprising that despite the increasing cases of DH, GIH is rarely reported. Underreporting is surprisingly pronounced in Africa, a region known to have documented several cases of DH [4,6,125,126,127]. An extensive review on histoplasmosis in Africa that spanned seven decades identified 470 cases of histoplasmosis, of which only one case was reported with GIH [5]. The paucity of data on GIH is first and foremost probably because histoplasmosis is still a neglected fungal disease in most parts of Africa, although with recent epidemiological studies, awareness is improving [125,126,127]. Recognition and reporting of GIH may also be hampered by a lack of adequate diagnostic procedures such as colonoscopy. The use of colonoscopy in the diagnosis of gastrointestinal conditions is still not routine in most African countries. Where such procedures are carried out, there is a dearth of studies on further specialised testing of biopsied samples for Histoplasma infection as a likely cause of gastrointestinal changes noted in affected individuals [128,129,130,131]. Prompt targeted evaluation of patients presenting with gastrointestinal disease for histoplasmosis will improve GIH case finding.
The non-specific signs and symptoms of GIH, as highlighted in this review, include but are not limited to abdominal pain [12,18,19,20,20,21,22,25,27,31,33,35,36,37,38,40,41,43,45,47,50,51,54], diarrhoea [12,17,19,21,22,36,37,38,39,40,43,53,68,74,75,103,104,105,106], fever [12,13,17,19,26,27,28,30,31,33,35], weight loss [13,31,77,79,84,98,100,104,111,121], vomiting [12,15,17,27,43,45,50,57,77,99], constipation [69,70,102], haematemesis and haematochezia [18,25,27,29,31,41,44,45,55,59,63,102,105] and associated endoscopic findings, which ranges from intestinal ulcerations [21,24,27,30,33,39,40,41,44,55,69,84,107], strictures [33] and friable masses [12,101] to ulcerated polyps [80]. This plethora of presentations could be misleading and asnon-specific often led to delays in the treatment of patients with GIH.- The initial misdiagnosis was often malignancy [80,83,108,112], inflammatory bowel disease [21,33,40,52,69,89,105,107,116] or acute exacerbation of inflammatory bowel disease for patients already on immunosuppressants [29,30,32,37,53,81] or tuberculosis [85,96,102]. As a result of delay, some patients experienced worsening clinical states [33,69,89,105,107,116] and/or death [20,80,100,116,122]. A high index of suspicion in evaluating GIH in patients is needed as this will reduce the incidence of complications, such as lower gastrointestinal bleeding [17,26,27,29,30,31,33,39,44,53,56,59,63,70,84,94,102,103,105,110,119], intestinal perforation [54,73,80,111], ulceration [70,102,103], intestinal obstruction [15,21,50,57,81,89,95,102,103,104,117], acute pancreatitis [20,65,75,115], acute cholecystitis [44,54,67,68,118] and death [94].
Inflammatory bowel disease (IBD) comprises Crohn’s disease (CD) and ulcerative colitis (UC). It is an autoimmune disorder of the gastrointestinal system, which is managed with immunosuppressive and anti-inflammatory drugs. CD can affect any part of the intestinal wall with a great extent of involvement of the full thickness of transmural mucosa, while UC affects the large colon predominantly with restriction of microscopic findings to the epithelial lining of the gut [132,133]. Presenting complaints of affected individuals are diarrhoea, abdominal pain, bloody stool and vomiting, similar to clinical features seen in individuals with GIH [132,133]. Similarly, the morphological findings during colonoscopy (grossly normal mucosa to oedematous/non-oedematous erythematous mucosa, superficial to deep ulcers with or without lacerations or perforations, strictures and polypoid masses) [84,91], as well as histopathological findings of lymphohistiocytic infiltrates and non-caseating granulomas in patients with GIH also bear semblance to those found in IBD [84,91], and can as well lead to misdiagnosis of GIH cases if deliberate screening for histoplasmosis is not done from the outset [8,105].
The clinicopathological features of GIH also mimic findings seen in intraabdominal malignancies, which can result in a diagnostic mishap if the possibility of Histoplasma infection is not explored from the outset [64]. Nine [16,18,33,82,85,103,104,110,114] out of the 123 case reports had presentations mimicking malignancy with treatment targeted at the presumptive diagnosis of malignancy in some of the cases before further evaluation and diagnosis of GIH was done [82,85,110,114]. Five of the patients with malignant mimics had HIV infection with CD4 counts less than 100 [33,82,104,110,114], two were patients on immunosuppressive therapy following lung transplantation (tacrolimus, mycophenolate and steroids) [18,103] and the remaining two were immunocompetent [16,85]. Presenting complaints were based on the site of involvement. Two of the patients had an anal mass and presented with anal pain [16,85] and anal seepage [16]. Lesions at the level of the colon were associated with fever, abdominal pain, [82,103,104,110] and weight loss [33,104,114]. Investigations were done with varied findings, such as an anal mass highly suspicious of neoplasm on pelvic imaging in the absence of other gastrointestinal involvement [16]. Colonoscopy findings were a friable pseudotumoral mass in the sigmoid colon [104], numerous ulcerated sessile polyps throughout the colon [18], oozing umbilicated colonic nodule [33] and ulceronodular growth in the sigmoid colon [82]. Though the gastrointestinal lesions were highly suggestive of malignancy, further evaluation was done for histoplasmosis through histopathology of biopsied specimens from the anus [16,85], colon [18,33,82,103,104] and other resected specimens [104,110], which were suggestive of infection with Histoplasma capsulatum. The antibody to Histoplasma [18] and urinary Histoplasma antigen test [18] were also positive. Treatment was surgery [82,103,110,114] and antifungal agents, including amphotericin B [33,82,104,114] and itraconazole [16,18,33,85,103,104,110,114], with good outcomes as evidenced by resolution of symptoms and regression of gastrointestinal signs. Nevertheless, death was recorded in one patient who also had tuberculosis co-infection [82].
DH can also be complicated with granulomatous hepatitis and/or cholestasis [5]. Thus, when an individual, especially in the setting of an immunocompromised state, presents with fever and jaundice, this disease entity should be considered or ruled out. Of the 123 cases, 16 had granulomatous hepatitis with six having coexisting cholecystitis [22,32,34,47,54,56,61,67,68,72,73,76,83,97,114,118]. Of the 16, 11 were immunocompromised secondary to HIV infection (n = 3) [68,72,114], post-transplantation on immunosuppressive therapy (n = 2) [61,72] and some were on immunosuppressive therapy for various ailments (n = 6), azathioprine [32,76], methotrexate [34,73,118], steroids [32,34,118], infliximab [32,73], fingolimod [54], mycophenolate, adalimumab [76,118], mesalazine [76] and the remainder were immunocompetent [22,47,56,67,97]. Investigations revealed markedly elevated liver enzymes with coexisting gall bladder disorder [22,44,54,67,68,118] and enlarged liver [32,34,68,83]. Diagnosis of granulomatous hepatitis was made via liver biopsy, which showed characteristic features of H.capsulatum [22,32,34,54,56,72,73,97]. F confirmatory investigations for histoplasmosis included positive antibody to Histoplasma (n = 6) [32,34,67,73,76,98], urinary Histoplasma antigen (n = 4) [34,56,67,76], blood culture (n = 3) [47,68,114] and bronchoalveolar lavage staining (n = 1) [114]. Treatment was surgical (cholecystectomy) for individuals with gall bladder involvement [22,68,72], in addition to antifungal therapy with itraconazole and amphotericin B. Marked recovery was noted with a resolution of symptoms and marked reduction in liver enzymes [22,32,34,56,61,67,76,83,114]; death was recorded in one case due to multiorgan failure [72]. Histoplasma though an uncommon cause of granulomatous hepatitis is associated with a high mortality rate of 100% [34,56] if not identified and treated.
Though rarely reported, disseminated Histoplasma infection can result in acute pancreatitis [20]. Acute pancreatitis is defined as an acute inflammatory process of the pancreas with variable involvement of other regional tissues or remote organ systems [134]. Its clinical manifestation spans from mild abdominal pain to multiple organ failure and sepsis with a high mortality rate [134]. Our review highlights four cases [20,65,77,116] of DH with pancreatic involvement; two were immunocompetent [77,116] while the other two patients were on systemic corticosteroids use [20,65]. The case reported by Asif et al. [20] was a patient with abdominal pain and CT findings of acute pancreatitis in addition to hypertriglyceridaemia. She was managed for acute pancreatitis secondary to hypertriglyceridaemia. Her condition deteriorated with associated complications leading to multiple organ failure and death. Diagnosis of DH with pancreatic involvement was made at post-mortem evaluation. Harris et al. reported an immunocompromised lady on methotrexate and prednisolone for rheumatoid arthritis [65]. She had a history of fever and abdominal pain with increased serum lipase three times the upper limit of normal and an abdominal CT scan of acute pancreatitis. She also had hypertriglyceridaemia. However, given the additional findings of cytopaenias, she had a bone marrow biopsy with histopathological examination done in order to evaluate further for haemophagocytic lymphohistiocytosis during which an incidental finding of Histoplasma infection was made and additional serologic testing for the infection was positive. Treatment with amphotericin B and itraconazole resulted in a complete resolution of symptoms [65]. Agrawal et al. [116] and Choudhary et al. [77] reported two cases of CT findings of mass in the head of the pancreas with the common bile duct [116] and duodenal obstruction [77], respectively. Symptoms were jaundice [116], vomiting and progressive weight loss [77]. Diagnosis of GIH was arrived at following endoscopic ultrasound scan guided fine needle aspiration [77] and pancreatectomy [116], with a concomitant histopathological examination, showing small yeasts consistent with Histoplasma. A further test for antibody to Histoplasma was also positive [77]. Treatment was with itraconazole [116] for one of the patients and voriconazole [77] for the other patient, as she reacted to itraconazole, with improvement of symptoms noted.
With regards to HIV-positive patients, GIH can present in different forms including acute abdomen, co-occurrence with tuberculosis, gastrointestinal bleeding, oesophageal histoplasmosis and intestinal obstruction. Guiot et al. [74] reported the case of a man who presented with acute abdomen seen as severe abdominal pain. He had emergency abdominal surgery, which disclosed a perforated ileum with histopathological findings of the resected segment suggestive of histoplasmosis. A confirmatory test was done with PCR. Additional treatment with antifungals was given with subsequent recovery [74].
The immunocompromised state of individuals with HIV could also result in co-infections where individuals have disseminated histoplasmosis in addition to other opportunistic infections, such as tuberculosis [80,89,100]. Diagnosis of GIH was delayed in one of the patients who was initially evaluated and treated for tuberculosis [100]. The patient’s condition deteriorated with worsening symptoms resulting in death before antifungal treatment could be initiated [100]. The diagnosis was made during post-mortem evaluation [100].
DH with gastrointestinal bleeding due to gastrointestinal involvement is rare [70]. It is seen twice as frequently in HIV/AIDS patients compared with immunocompetent patients [7]. It can cause upper or lower gastrointestinal bleeding depending on the site of involvement [56]. Lower gastrointestinal bleeding may be more common as GIH predominantly affects the ileum and colon as a result of its abundant lymphoid tissue [6]. Lower gastrointestinal bleeding secondary to histoplasmosis is associated with a high mortality rate (20–25%) in those who are immunocompromised [92]. Of the 29 patients with gastrointestinal bleeding, seven were HIV positive [31,41,44,55,71,110,119]. Consideration of GIH in patients with gastrointestinal bleeding is required.
The prevalence of oesophageal histoplasmosis is also higher in individuals with HIV/AIDS, which is said to occur in 3–3.8% of cases [12,13]. Oesophageal histoplasmosis is linked to the early phase of histoplasmosis infection predominantly due to adjoining mediastinal adenitis [6,75] or later from progressive scarring in fibrosing mediastinitis or disseminated disease [6,82]. Endoscopic findings in GIH involving the oesophagus could be erythema or local inflammation [40,42,56,58,105], polyps [13] and ulcerations [20,84,100,104,121]. During the period under review, twelve patients [13,20,40,42,48,56,58,84,100,104,105,121] presented with GIH with oesophageal involvement and five were immunocompromised [13,40,100,104,121] with HIV infection. Treatment with intravenous amphotericin B and itraconazole [13,40,42,48,56,58,84,104,105,121] resulted in a favourable outcome; one patient died due to dual opportunistic infection with tuberculosis [100] and the other died before treatment was commenced [20].
GIH has been identified as a rare cause of intestinal obstruction seen predominantly in people living with HIV/AIDS [50]. This is due to the spectrum of gastrointestinal morphological changes seen in GIH from pseudo-polyps and plaque, ulcerations in the mucosa, stricture formation and thickening of the bowel that affect sites between the duodenum and terminal ileum leading to obstructive symptoms [104]. Past reports of GIH in HIV-infected patients identified that 70% had symptoms of fever and abdominal pain, and 50% had weight loss and diarrhoea [50].
Focusing on cases without HIV infection, the findings from our review suggest the need to also evaluate patients without HIV infection with risk factors for GIH including post-transplant patients on immunosuppressants [16,39,46,49,61,62,63,72,84,101,113], patients on immunosuppressants for other disease conditions [14,15,17,20,25,28,30,69,76,92,103,105] and patients with immunodeficiency syndrome [95] presenting with GI symptoms. This should be done regardless of the immune status of an individual as complications associated with GIH, such as acute abdomen [70], can also develop in immunocompetent patients. Unfavourable outcomes were mainly seen in cases with HIV infection and those receiving amphotericin B deoxycholate monotherapy, and most likely reflect a delayed and more severe clinical disease presentation.
A delayed diagnosis that resulted in the need for surgery was reported as well. Diagnosis of GIH was made following histopathological analysis of a surgically resected specimen [21,33,35,37,60,80,89,94,105,108,109]. Treatment was given with antifungal drugs; thereafter with recovery recorded. However, in the case report by Koh et al. [94] and Seghal et al. [80], the patients died following surgery as a result of delayed diagnosis and treatment for GIH. These cases further buttress the need for a high index of suspicion for GIH in patients presenting with gastrointestinal disease.

5. Limitations of the Study

The databases searched for publications included in this review were limited to Pubmed, Google scholar and African Journals Online and so may have missed cases documented in grey literature and other journal articles not available in the searched databases. Moreover, the exclusion of some cases from statistical analysis due to the unavailability of clinical and pathological findings may have influenced the outcome of our analysis.

6. Conclusions

GIH occurs with significant frequency in people without HIV infection with similar clinical features and pathological findings as seen in persons living with HIV. The need for an increased index of suspicion in people without HIV infection presenting with GI symptoms and risk factors for GIH is emphasised. In addition, the geographical distribution of GIH cases across the globe suggests a gross underreporting from Africa, despite having a significant at-risk population. Routine screening for histoplasmosis in at-risk patients presenting with gastrointestinal disease will improve GIH case finding.

Author Contributions

Conceptualization, draft manuscript, literature review, data curation, writing, review and edits; B.E.E., literature review, data curation, writing, review and edits; A.E.I.-E., writing, review and edits; I.I.O., literature review, writing, review and edits; A.W., review and edits; R.O.O., F.B. and D.W.D. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

Not applicable.

Informed Consent Statement

Not applicable.

Data Availability Statement

Data sharing is not applicable to this article.

Conflicts of Interest

The authors declare no conflict of interest.

References

  1. Ashraf, N.; Kubat, R.C.; Poplin, V.; Adenis, A.A.; Denning, D.W.; Wright, L.; McCotter, O.; Schwartz, I.; Jackson, B.; Chiller, T. Re-drawing the Maps for Endemic Mycoses. Mycopathologia 2020, 185, 843–865. [Google Scholar] [CrossRef]
  2. Ekeng, B.E.; Edem, K.; Amamilo, I.; Panos, Z.; Denning, D.W.; Oladele, R.O. Histoplasmosis in Children; HIV/AIDS Not a Major Driver. J. Fungi 2021, 7, 530. [Google Scholar] [CrossRef]
  3. Ekeng, B.E.; Oladele, R.O.; Emanghe, U.E.; Ochang, E.A.; Tatfeng, Y.M. Prevalence of Histoplasmosis and Molecular characterization of Histoplasma in patients with presumptive pulmonary tuberculosis in Calabar, Nigeria. Open Forum Infect. Dis. 2022, 9, ofac368. [Google Scholar] [CrossRef]
  4. Mandengue, C.E.; Ekeng, B.E.; Oladele, R.O. Disseminated Histoplasmosis; A threat in advanced HIV Disease population in sub-Saharan Africa? J. Adv. Med. Med. Res. 2021, 33, 115–144. [Google Scholar] [CrossRef]
  5. Oladele, R.O.; Ayanlowo, O.O.; Richardson, M.D.; Denning, D.W. Histoplasmosis in Africa: An emerging or a neglected disease? PLoS Negl. Trop. Dis. 2018, 12, e0006046. [Google Scholar] [CrossRef]
  6. Ekeng, B.E.; Edem, K.; Akintan, P.; Oladele, R. Histoplasmosis in African children: Clinical features, Diagnosis and Treatment. Ther. Adv. Infect. Dis. 2022, 9, 1–6. [Google Scholar] [CrossRef]
  7. MacInnes, R.; Warris, A. Paediatric histoplasmosis 2000–2019: A review of 83 cases. J. Fungi 2021, 7, 448. [Google Scholar] [CrossRef]
  8. Assi, M.A.; Sandid, M.S.; Baddour, L.M.; Roberts, G.D.; Walker, R.C. Systemic histoplasmosis. Medicine 2007, 86, 162–169. [Google Scholar] [CrossRef]
  9. Kahi, C.J.; Wheat, S.D.; Allen, G.A.; Sarosi, A. Gastrointestinal Histoplasmosis. Am. J. Gastroenterol. 2005, 100, 220–231. [Google Scholar] [CrossRef]
  10. Wheat, L.J.; Connolly-Stringfield, P.A.; Baker, R.L.; Curfman, M.F.; Eads, M.E.; Israel, K.S.; Norris, S.A.; Webb, D.H.; Zeckel, M.L. Disseminated histoplasmosis in the acquired immune deficiency syndrome: Clinical findings, diagnosis and treatment, and review of the literature. Medicine 1990, 69, 361–374. [Google Scholar] [CrossRef]
  11. Nacher, M.; Valdes, A.; Adenis, A.; Blaizot, R.; Abboud, P.; Demar, M.; Djossou, F.; Epelboin, L.; Misslin, C.; Ntab, B. Gastrointestinal disseminated histoplasmosis in HIV-infected patients: A descriptive and comparative study. PLoS Negl. Trop. Dis. 2021, 22, e0009050. [Google Scholar] [CrossRef] [PubMed]
  12. Suk, N.K.; Anekthananon, T.; Mariuz, P.R. Gastrointestinal Histoplasmosis in Patients with AIDS: Case Report and Review. Clin. Infect. Dis. 2001, 32, 481–491. [Google Scholar]
  13. Finniss, M.; Lewis, P.; Myes, J.; Ibrahim, L.; Patel, P. A Case of Gastrointestinal Histoplasmosis with Esophageal involvement. Clin. J. Gastroenterol. 2020, 13, 173–177. [Google Scholar] [CrossRef] [PubMed]
  14. Wheelbright, M.; Yousaf, H.; Plummer, R.; Cartwright, D.; Gaertner, W.; Amin, K. Perianal Histoplasmosis presenting as a mass suspicious for malignancy: A Case Report with Review of Gastrointestinal Manifestations of Histoplasmosis. Am. J. Case Rep. 2019, 20, 1740–1744. [Google Scholar] [CrossRef]
  15. Nawaz, Z.; Martin, S.; Reichstein, A.R. Gastrointestinal Histoplasmosis as an Obstructing Ileocaecal mass. Cureus 2020, 12, e12277. [Google Scholar] [PubMed]
  16. Cui, M.; Wong, R.C.K.; Gholam, P.M. Colonic Histoplasmosis presenting as polyps in an asymptomatic patient with liver transplant. ACG Case Rep. J. 2021, 8, e00598. [Google Scholar] [CrossRef]
  17. Aseem, O.; Childs, D.S.; Loftus, C.G. Diffuse small intestine erosions and ulcers in an immunocompromised host. Gastroenterology 2018, 5, 1241–1243. [Google Scholar] [CrossRef] [Green Version]
  18. Tella, S.H.; Abuzaid, A. Disseminated Histoplasmosis in an HIV patient with CD4 count of 1cells/ul. BMJ Case Rep. 2014, 19, bcr2013202906. [Google Scholar] [CrossRef] [Green Version]
  19. Bhinder, J.; Mon, A.; Cao, W.; Malieckal, A. A Case of Isolated Gastrointestinal Histoplasmosis. Cureus 2018, 10, e2951. [Google Scholar] [CrossRef] [Green Version]
  20. Asif, A.A.; Roy, M.; Ahmad, S. Fulminant Pancreatitis Due to Disseminated Histoplasmosis: Case Report and Literature Review. Cureus 2020, 12, 12168. [Google Scholar] [CrossRef]
  21. Lee, C.; Jasurda, J.; Wing, A. An HIV positive Patient with Disseminated Histoplasmosis complicated by Histoplasma ileitis-induced Small Bowel Obstruction. Cureus 2021, 13, e14677. [Google Scholar] [CrossRef] [PubMed]
  22. Muhanna, A.; Nimri, F.M.; Almomani, Z.A.; Momani, L.A.; Likbitsup, A. Granulomatous Hepatitis Secondary to Histoplasmosis in an Immunocompetent patient. Cureus 2021, 13, e17631. [Google Scholar] [CrossRef] [PubMed]
  23. McCollough, K.; Damjanov, I. Intestinal Histoplasmosis mimicking Whipple’s disease. Histopathology 2006, 48, 306–323. [Google Scholar] [CrossRef]
  24. Rodriguez-Waitkus, P.M.; Bayat, V.; George, E.; Sule, N. Gastrointestinal Histoplasmosis in a Hepatitis C infected Individual. Mycopathologia 2013, 176, 161–164. [Google Scholar] [CrossRef]
  25. Zhang, B.; Martin, V.K.; Notamedi, N.; Shao, L. Isolated Ileocolonic Histoplasmosis in an HIV-negative patient. Dig. Dis. Sci. 2017, 62, 2201–2202. [Google Scholar] [CrossRef]
  26. Syed, T.A.; Salem, G.; Kantens, D.J. Lower Gastrointestinal Bleeding Secondary to Intestinal Histoplasmosis in a Renal Transplant Patient. ACG Case Rep. J. 2017, 4, e93. [Google Scholar] [CrossRef]
  27. Panchabhal, T.S.; Bals, R.K.; Pyle, R.C.; Mitchell, C.K.; Arnold, F.W. An Apple Core Lesion in the Colon: An infectious Etiology. J. Glob. Infect. Dis. 2011, 3, 195–198. [Google Scholar] [CrossRef]
  28. Jain, V.V.; Evans, T.; Peterson, M.W. Reactivation Histoplasmosis after treatment with anti-tumor necrosis factor alpha in a patient from a non-endemic area. Respir. Med. 2016, 100, 1291–1293. [Google Scholar] [CrossRef] [Green Version]
  29. Dahiya, D.; Kichloo, A.; Singh, J.; Albosta, M.; Wani, F. Histoplasmosis and Inflammatory Bowel Disease: A Case Report. World J. Gastrointest. Endosc. 2021, 16, 24–32. [Google Scholar] [CrossRef]
  30. Bates, R.; Wan, S.; Sohail, M.R. A 44 yr Old man with Abdominal Pain, Fever and Bloody diarrhea. Mayo Clin. Proc. 2015, 90, e59–e62. [Google Scholar] [CrossRef] [Green Version]
  31. Aisenberg, G.; Marcos, L.A.; Ogbaa, I. Recurrent Histoplasmosis in AIDS mimicking a colonic carcinoma. Int. J. STD AIDS 2009, 20, 429–430. [Google Scholar] [CrossRef]
  32. Ferreira, S.C.; Nobrega, F.J.F.; Araujo, R.C.; Almeida, P.H.; Villanova, M.G.; Santana, R.C.; Ramalho, L.N.Z.; Martinelli, A.C.C.; Troncon, L.E.A. Histoplasmosis related to Immunosuppression in a patient with Crohn’s Disease: A Diagnostic Challenge. Am. J. Case Rep. 2021, 22, e925345. [Google Scholar] [CrossRef]
  33. Goulet, C.J.; Moseley, R.H.; Tonnerre, C.; Sandhy, I.S.; Saint, S. The Unturned Stone. N. Engl. J. Med. 2005, 352, 489–494. [Google Scholar] [CrossRef]
  34. Kibria, R.; Bari, K.; Ali, S.A.; Barde, C.J. “Ohio River Valley Fever” Presenting as isolated Granulomatous Hepatitis: A Case Report. South. Med. J. 2009, 102, 656–658. [Google Scholar] [CrossRef]
  35. Johnson, M.P.; Diffalha, S.A.; Gunnells, D.J. Jejunal Perforation secondary to Histoplasmosis. J. Gastrointest. Surg. 2021, 25, 3004–3006. [Google Scholar] [CrossRef]
  36. Rowe, K.M.; Green, M.; Nehme, F.; Tofteland, N. Isolated Ileal Stricture Secondary to Antigen Negative Gastrointestinal Histoplasmosis in a Patient on Immunosuppressive Therapy. ACG Case Rep. J. 2017, 4, e10. [Google Scholar] [CrossRef]
  37. Butler, B.; Venkata, K.; Escoria-Ecleon, E.; Ajit, R.; Nelson-Garett, N. Gastrointestinal Histoplasmosis Causing Intestinal Perforation in a Crohn’s Disease Patient Taking TNF-alpha Inhibitor. Am. J. Gastroenterol. 2010, 111, 810. [Google Scholar] [CrossRef]
  38. Okura, M.S.; Wang, T.; Ameer, A. Gastrointestinal Histoplasmosis in an Immunocompetent Adult in a Non-Endemic Region. Am. J. Gastroenterol. 2021, 116, 817–818. [Google Scholar] [CrossRef]
  39. Patel, N.; Nguyen, B.C.; Stein, D.; Evans, J.; Beniwal-Patel, P. Two Unusual Manifestations of Gastrointestinal Histoplasmosis. Am. J. Gastroenterol. 2020, 115, 856–857. [Google Scholar] [CrossRef]
  40. Nakshabendi, R.; Berry, A.C.; Torres-Miranda, D.; LaBarbera, F.D.; Kanar, O.; Nakshabandi, A.; Nakshabendi, I. Primary Histoplasma capsulatum Enterocolitis Mimicking Peptic and Inflammatory Bowel Disease. Case Rep. Gastrointest. Med. 2016, 2016, 7139573. [Google Scholar]
  41. Patel, N.M.; Schwartz, D.J. Lower GI bleeding from Ileocolonic Histoplasmosis. Gastrointest. Endosc. 2011, 74, 1404–1405. [Google Scholar] [CrossRef]
  42. Sani, S.; Bilal, J.; Varma, E.; Kollampare, S.; Sudano, D. Not Your Typical Arizona Granuloma: A Case Report of Disseminated Histoplasmosis. Am. J. Med. 2018, 9, 375–376. [Google Scholar] [CrossRef]
  43. Chudy-Onwugaje, K.; Anyadike, N.; Mayer, I.; Rahmani, R. Colonic Histoplasmosis: An Uncommon Cause of Intractable Diarrhea. Am. J. Gastroenterol. 2013, 108, 371–372. [Google Scholar] [CrossRef]
  44. Spinner, M.A.; Paulin, H.N.; Wester, C.W. Duodenal Histoplasmosis Presenting with Upper Gastrointestinal Bleeding in an AIDS Patient. Case Rep. Gastrointest. Med. 2012, 2012, 515872. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  45. Anderson, B.R.; Marriot, J.; Bulathsinghala, C.; Anjum, H.; Surani, S. Gastrointestinal Histoplasmosis Presenting as an Acute Abdomen with Jejunal Perforation. Case Rep. Med. 2018, 2018, 8923972. [Google Scholar] [CrossRef] [PubMed]
  46. Ghassemi, K.F.; Wang, R.T.; Muthusamy, V.R.; Shah, J.N. Colonic Histoplasmosis. Gastroenterol. Hepatol. 2007, 3, 459–460. [Google Scholar]
  47. Gill, D.; Dean, R.; Virk, J.; Lyons, M.; Hess, M. Unusual Presentation of Disseminated Histoplamosis. Am. J. Emerg. Med. 2016, 35, e3–e668. [Google Scholar]
  48. Chaudhari, D.; Mckinney, J.; Hubbs, D.; Young, M. Mediastinal Histoplasmosis Presenting as Dysphagia: A case report with literature review. Clin. J. Gastroenterol. 2013, 6, 315–318. [Google Scholar] [CrossRef]
  49. Gajula, P.; Ahmad, M.I.; Zhang, D.S.; Schiesser, R.L. Gastrointestinal histoplasmosis, a rare and devastating disease. Am. J. Gastroenterol. 2020, 115, 943. [Google Scholar] [CrossRef]
  50. Escobar, B.; Maldonado, V.N.; Ansari, S.; Samia, J.C. Antigen Negative Gastrointestinal Histoplasmosis in an AIDS patient. AMJ Case Rep. 2014, 15, 90–93. [Google Scholar]
  51. Thomas, A.S.; Elnemr, M.; Abraham, B. Primary Gastrointestinal Histoplasmosis and Vedolizumab. Am. J. Gastroenterol. 2016, 111, 822. [Google Scholar] [CrossRef]
  52. Steiner, S.J.; Kleiman, M.B.; Corkins, M.R.; Christenson, J.C.; Wheat, L.J. Ileocecal Histoplamosis Simulating Crohn Disease in a Patient with Hyperimmunoglobulin Syndrome. J. Pediatr. Infect. Dis. 2009, 28, 744–746. [Google Scholar] [CrossRef]
  53. Galandiuk, S.; Davis, B.R. Infliximab-induced disseminated histoplasmosis in a patient with Crohn’s disease. Nat. Clin. Pract. Gastroenterol. Hepatol. 2008, 5, 285–288. [Google Scholar] [CrossRef]
  54. Abrahamowicz, A.A.; Chow, E.J.; Child, D.D.; Dao, A.; Morrison, E.D.; Gill, S.K.; Rogers, D.M.; Garvin, K. Disseminated Histoplasmosis in a Patient with Multiple Sclerosis Treated with Fingolimod. Neurol. Neuroimmunol. Neuroinflamm. 2021, 8, 966. [Google Scholar] [CrossRef]
  55. Dodin, J.; Xie, C.; Jensen, C.H.; Shreshtha, A. An Unusual case of GI Bleeding: Could Histoplasmosis be the Culprit? S. D. Med. 2019, 72, 250–252. [Google Scholar]
  56. Wong, P.; Houston, S.; Power, B.; Lalor, E.; Bain, V.G. A case of Histoplasma capsulatum causing granulomatous liver disease and Addisonian crisis. Am. J. Gastroenterol. 2001, 15, 687–691. [Google Scholar]
  57. Gnecco, J.; Ameesh, D.; Penninti, P.; Echavarria, J.; Ladak, F.; Edelson, J. Obstructive Histoplasmosis Resulting in Recurrent Nausea and Vomiting. Am. J. Gastroenterol. 2021, 116, 1259–1260. [Google Scholar] [CrossRef]
  58. Prakash, S.; Merza, N.; Mansi, T.; Yousuf, H.; Trehan, A. Gut Feeling: Isolated Colonic Histoplasmosis. Am. J. Gastroenterol. 2020, 115, 938–939. [Google Scholar] [CrossRef]
  59. Jacob, K.; Balouch, I. A Colonic Mass, Abdominal Pain and Gastrointestinal Bleeding: A Presentation of Gastrointestinal Involvement in Disseminated Histoplasmosis. Am. J. Gastroenterol. 2017, 112, S802–S803. [Google Scholar] [CrossRef]
  60. Ordonez, M.; Fahy, B.; Sessoms, S.; Barrios, R. Colonic Histoplasmosis Mimicking Malignant Ulceration. Am. Coll. Gastroenterol. 2010, 105, 345. [Google Scholar] [CrossRef]
  61. Washburn, L.; Galvan, N.T.; Dhingra, S.; Rana, A.; Goss, J.A. Histoplasmosis hepatitis after orthotopic liver transplantation. J. Surg. Case Rep. 2017, 2017, rjx232. [Google Scholar] [CrossRef] [Green Version]
  62. Benson, B.C.; Schwake, J.W. Disseminated Histoplasmosis Diagnosed on Routine Outpatient Endoscopy. Am. J. Gastroenterol. 2017, 112, 796–797. [Google Scholar] [CrossRef]
  63. Lopez, F.; Reddy, A.; Birris, T. A Rare Case of Gastrointestinal Histoplasmosis in an Immunocompromised Host. Am. J. Gastroenterol. 2017, 112, 1338–1339. [Google Scholar] [CrossRef]
  64. Mohan, M.; Fogel, B.; Eluvathingal, T.; Schinke, C.; Kothari, A. Gastrointestinal histoplasmosis in a patient after autologous stem cell transplant for multiple myeloma. Transpl. Infect. Dis. 2016, 18, 939–941. [Google Scholar] [CrossRef]
  65. Harris, C.E.; Jansson-Knodell, C.L.; Virk, A. 69 year-old woman with fevers, diarrhea and abdominal pain. Mayo Clin. Proc. 2019, 94, 61–66. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  66. Zarrinpar, A.; Un, G.; Lonergon, J.I. A Rare Cause of Ileocaecal Fistula in an AIDS patient. Gastroenterology 2013, 144, 697–858. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  67. Park, S.; Cheong, J.; Kyi, K.; Aranez, J.; Abu-Farsakh, S.; Whitney-Miller, C.; Judaihi, B.; Laruea, M. Cholestatasis and disseminated Histoplasmosis in a Psoriatic Patient on Infliximab: Case Report and review of literature. Gastroenterology 2020, 20, 141. [Google Scholar] [PubMed]
  68. Shinha, T.; Zabarsky, G. Acalculous Cholecystitis Due to Histoplasma capsulatum in a Patient with HIV Infection. ACG Case Rep. J. 2015, 2, 245–246. [Google Scholar] [CrossRef]
  69. Shojaei, E.; Walsh, J.C.; Sangle, N.; Yan, B.; Silverman, M.S.; Hosseini-Moghaddam, S.M. Gastrointestinal Histoplasmosis mimicking Crohn’s disease. Open Forum Infect. Dis. 2021, 8, ofab249. [Google Scholar] [CrossRef]
  70. Jiménez-Rivera, E.; Dávila-Ruiz, E.O.; García-Manzano, R.A.; Santos-Chab, G.A.; Aguirre-Trejo, J.M.; Fabián, F.; Tafoya-Ramirez, F. Intestinal histoplasmosis in immunocompetent patient: An unusual cause of massive small intestine bleeding. Rev. Médica Hosp. Gen. México 2021, 84, 43–48. [Google Scholar] [CrossRef]
  71. Gumbs, M.A.; Girishkumar, H.; Yousuf, A.; Levy, L.; Patel, M.; Narashima, V. Histoplasmosis of the Small bowel in patients with AIDS. Post Grad. Med. J. 2000, 76, 364–372. [Google Scholar] [CrossRef] [Green Version]
  72. Kothadia, J.P.; Kone, V.; Giashuddin, S. Granulomatous hepatitis: A rare primary manifestation of disseminated histoplasmosis in a renal transplant recipient. J. Gastrointest. Liver Dis. 2017, 26, 114. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  73. Rihana, N.A.; Kandula, M.; Velez, A.; Dahal, K.; O’Neill, E.B. Histoplasmosis presenting as granulomatous hepatitis: Case report and review of the literature. Case Rep. Med. 2014, 2014, 879535. [Google Scholar] [CrossRef] [Green Version]
  74. Guiot, H.M.; Bertran-Pasareli, J.; Tormos, L.M.; Gonzalez-Keelan, C.; Procop, G.W.; Fradera, J.; Sanchez-Sergenton, C.; Mendez, W. Ileal perforation and reactive hemophagocytic syndrome in a patient with disseminated histoplasmosis: The role of the real time PCR in the diagnosis and successful treatment with amphotericin B lipid complex. Diagn. Microbiol. Infect. Dis. 2007, 57, 429–433. [Google Scholar] [CrossRef]
  75. Aggarwal, A.; Garg, S. Isolated ancrreatic Histoplasmosis: An Unusual Suspect of Pancreatic Head Mass in an Immunocompetent Host. Perm. J. 2015, 19, e145–e147. [Google Scholar] [CrossRef] [Green Version]
  76. Pinheiro Bdo, V.; Delgado Ade, A.; Chebli, J.M. Hepatitis and pneumonitis during adalimumab therapy in Crohn disease: Mind the histoplasmosis. Arq. Gastroenterol. 2014, 51, 73–76. [Google Scholar] [CrossRef] [Green Version]
  77. Choudhary, N.S.; Puri, R.; Paliwal, M.; Guleria, M.; Sud, R. Histoplasmosis presenting as pancreatic head mass lesion and gastric outlet obstruction in an immunocompetent patient. Endoscopy 2014, 46, E411–E412. [Google Scholar] [CrossRef] [Green Version]
  78. Dawra, S.; Mandavdhare, H.S.; Prasad, K.K.; Dutta, K.; Sharma, V. Gastrointestinal: Unusual Case of Ileocaecal thickening in an Immunocompromised patient: A Histologic Surprise. J. Gastroenterol. Hepatol. 2018, 33, 769. [Google Scholar] [CrossRef]
  79. Jha, V.K.; Mahapatra, O. Disseminated Histoplasmosis Masquerading as significant weight loss eight years post Renal Transplant. Saudi J. Kidney Dis. Transpl. 2020, 31, 868–873. [Google Scholar] [CrossRef]
  80. Sehgal, S.; Chawla, R.; Loomba, P.S.; Mishra, B. Gastrointestinal Histoplasmosis presenting as colonic pseudotumour. Indian J. Med. Microbiol. 2008, 26, 187–189. [Google Scholar] [CrossRef]
  81. Bhut, B.; Kulkami, A.; Rai, C.; Agrawal, V.; Verma, A.; Jain, M.; Marak, R.S.K.; Dixit, A.K.; Ghoshal, U.C. A rare case of Disseminated Histoplasmosis in a patient with Crohn’s disease an immunosuppressive treatment. Indian J. Gastroenterol. 2018, 37, 472–474. [Google Scholar] [CrossRef] [PubMed]
  82. Rana, C.; Krishnani, N.; Kumari, N.; Shastri, C.; Poddar, U. Rectal Histoplasmosis in Job’s syndrome. Indian J. Gastroenterol. 2013, 32, 64–65. [Google Scholar] [CrossRef] [PubMed]
  83. Singh, M.; Sharma, A.; Sankhala, K.; Bareth, H.; Suman, S. Progressive Disseminated Histoplamosis mimicking as Anal Carcinoma: Look at the mountain, not at the stone: A Case Report. J. Multidiscip. Healthc. 2021, 14, 2749–2754. [Google Scholar] [CrossRef] [PubMed]
  84. Sharma, R.; Lipi, L.; Gajendra, S.; Mohapatra, I.; Goel, R.K.; Duggal, R.; Mishra, S.R.; Gautam, D. Gastrointestinal Histoplasmosis: A Case Series. Int. J. Surg. Pathol. 2016, 53, 1–7. [Google Scholar] [CrossRef] [PubMed]
  85. Parikh, F.; Londhe, V.A.; Hude, S.; Kamat, R.; Kamath, S.A. Gastrointestinal Histoplasmosis Mimicking Abdominal Tuberculosis. Am. J. Gastroenterol. 2005, 100, 1896–1897. [Google Scholar]
  86. Barman, B.; Ete, T.; Mishra, J.; Jha, P.; Phukan, P.; Warjri, S.B.; Padmanabhan, A. Abdominal histoplasmosis mimicking tuberculosis in an immunocompromised patient. J. Res. Med. Dent. Sci. 2015, 3, 317–319. [Google Scholar] [CrossRef]
  87. Subbalaxmi, M.V.S.; Umabala, P.; Paul, R.; Chandra, N.; Raju, Y.S.; Rudramurthy, S.M. A rare presentation of progressive disseminated histoplasmosis in an immunocompetent patient from a non-endemic region. Med. Mycol. Case Rep. 2013, 2, 103–107. [Google Scholar] [CrossRef]
  88. Yang, B.; Lu, L.; Li, D.; Liu, L.; Huang, L.; Chen, L.; Tang, H.; Wang, L. Colonic Involvement in Disseminated Histoplasmosis of an Immunocompetent Adult: A Case Report and Literature Review. BMC Infect. Dis. 2013, 13, 143. [Google Scholar] [CrossRef] [Green Version]
  89. Ai, X.; Wang, Z.; Dong, Q.; Lin, X.; Chen, Y.; Gong, F.; Liang, H. Ileum Histoplasmosis mimicking Intestinal tuberculosis and Crohn’s disease. Case Rep. Gastroenterol. 2018, 12, 63–68. [Google Scholar] [CrossRef] [Green Version]
  90. Dang, Y.; Jiang, L.; Zhan, J.; Pan, B.; Zhu, G.; Zhu, F.; Guo, Z.; Wang, B.; Zhang, G.; Weng, Y.; et al. Disseminated Histoplasmosis in an Immunocompetent Individual diagnosed with Gastrointestinal Endoscopy: A Case Report. BMC Infect. Dis. 2019, 19, 992. [Google Scholar] [CrossRef]
  91. Zhu, L.; Zhang, W.; Yang, L.; Guo, T.; Su, C.; Yang, J. Disseminated Histoplasmosis: Intestinal Multiple Ulcers without Gastrointestinal symptoms in an Immune Competent Adult. J. Cytol. Histol. 2014, 5, 231. [Google Scholar] [CrossRef] [Green Version]
  92. Lai, C.; Huang, C.; Chin, C.; Yang, Y.; Lin, H.; Lin, H. Indigenous Case of Disseminated Histoplasmosis Taiwan. Emerg. Infect. Dis. 2007, 13, 127–129. [Google Scholar] [CrossRef] [PubMed]
  93. Natarajan, S.K.; Choozw, R.A.O.; Lang, T.U. Gastrointestinal Manifestation of Disseminated Histoplasmosis in a non endemic region. ANZ J. Surg. 2017, 87, 207–211. [Google Scholar] [CrossRef]
  94. Koh, P.S.; Roslani, A.C.; Vimal, K.V.; Shariman, M.; Umasengar, R.; Lewellyn, R. Concurrent Amebic and Histoplasma Colitis: A rare cause of massive gastrointestinal bleeding. World J. Gastroeterol. 2010, 16, 1296–1298. [Google Scholar] [CrossRef] [PubMed]
  95. Nehme, F.; Rowe, K.; Hawari, M.; Assi, M.; Nassif, I. Gastrointestinal Histoplasmosis Ileal Stricture Successfully Treated with through-the-scope balloon dilatation in a patient with hyperimmunoglobulin M syndrome. Clin. J. Gastroenterol. 2018, 11, 224–228. [Google Scholar] [CrossRef] [PubMed]
  96. Paul, N.; Swaminathan, S.; Ganesh, A.; Abdelsayeed, G. Gastrointest. Histoplasmosis 439. Am. J. Gastroenterol. 2007, 102, S276. [Google Scholar] [CrossRef]
  97. Wee, E.W.L.; Lim, S.G.; Wee, A.; Chai, L.Y. Disseminated Histoplasmosis presenting as fever and Jaundice. Ann. Acad. Med. 2009, 38, 739. [Google Scholar] [CrossRef]
  98. Mandavdhare, H.S.; Shah, J.; Prasad, K.K.; Agarwala, R.; Suri, V.; Kumari, S.; Dutta, U.; Sharma, V. Gastrointestinal histoplasmosis: A case series from a non-endemic region in North India. Intest. Res. 2019, 17, 149–152. [Google Scholar] [CrossRef] [Green Version]
  99. Franca, C.M.P.; Cavalcante, E.G.; Ribeirro, A.S.M.; Oliveira, G.T.; Litvinov, N.; Silva, C.A. Disseminated histoplasmosis in a juvenile lupus erythematosus patient. Acta Reumatol. Port. 2012, 37, 276–279. [Google Scholar]
  100. Rezende, R.E.F.; Brunaldi, M.; Girao, M.S.; Zucoloto, S.; Garcia, S.B.; Machado, A.A.; Mόdena, J.L.P. Esophageal Histoplasmosis Associated with Disseminated Tuberculosis in Acquired Immunodeficiency Syndrome. Am. J. Trop. Med. Hyg. 2009, 80, 347–350. [Google Scholar] [CrossRef]
  101. Ferreira, G.S.A.; Watanabe, A.L.C.; Trevizoli, N.C.; Jorge, F.M.F.; Camposa, P.B.; Couto, C.F.; Lima, L.; Raupp, D.R.L. Colonic Infection by Histoplasma capsulatum in a Liver Transplant Patient: A Case Report. Transplant. Proc. 2020, 52, 1413–1416. [Google Scholar] [CrossRef] [PubMed]
  102. Hallo, A.; Camacho, M.; Rojas, A.; Mayanala, A.; Castillo, A. Atypical Obstructive Pseudotumors in AIDS as the initial manifestation of Gastrointestinal Histoplasmosis. Cureus 2020, 12, e7775. [Google Scholar] [CrossRef] [Green Version]
  103. Oliveras, B.; Albert, M.; Lopez, C.; Fort, E.; Peries, L.; Gutierrez, L.; Busquets, D.; Uchima, H.; Aldeguer, X.; Pinol, V. A case Report of Gastrointestinal Histoplasmosis in a Patient treated with Infliximab. Clin. J. Gastroenterol. 2020, 14, 690–692. [Google Scholar] [CrossRef]
  104. Hertan, H.; Nair, S.; Arguello, P. Progressive Gastrointestinal Histoplasmosis leading to Colonic Obstruction two years after initial presentation. Am. J. Gastroenterol. 2001, 96, 221–222. [Google Scholar] [CrossRef] [PubMed]
  105. Ahmed, A.; Homsi, N.; Kapila, R. Crohn’s Disease or Histoplasmosis? A Case of Severe Disseminated Histoplasmosis mimicking Crohn’s disease and literature review. Med. Mycol. Case Rep. 2020, 30, 8–11. [Google Scholar] [CrossRef] [PubMed]
  106. Rali, P.; Naing, W.; Fabbri, M.; Asraf, A. Isolated Case of Gastrointestinal Histoplasmosis in a Young Male Patient Diagnosed with Acquired Immunodeficiency Syndrome (AIDS) Presenting as Fever of Unknown Origin. Am. J. Gastroenterol. 2012, 107, 472. [Google Scholar] [CrossRef]
  107. Hattenhauer, J.; Law, A.; Dvorzhinksiy, O.; Vinod, J. Gastrointestinal Histoplasmosis Masquerading as Crohn’s Disease in the Immunocompetent Adult. Am. J. Gastroenterol. 2020, 115, S1184. [Google Scholar] [CrossRef]
  108. Montalvo, R.; Pomalaza, G.; Sandoval, M.; Quispe, J. Disseminated Histoplasmosis and Miliary Tuberculosis Imitating Colon Cancer in Patient with HIV Who Refuses to Antirretroviral Treatment. Mycopathologia 2020, 185, 583–586. [Google Scholar] [CrossRef]
  109. Alave, J.; Bustamante, B.; Soto, L.; Caceres, J.; Seas, C. Acalculous Cholecystitis caused by Histoplasma capsulatum in a severely immunosuppressed HIV-infected patient. J. Infect. Dev. Ctries. 2011, 5, 235–238. [Google Scholar] [CrossRef] [Green Version]
  110. Bruno, M.A.; Parodi, M.; Olmedo, I.; Picomolina, H.; Palencia, R.; Doniquian, A. Massive gastrointestinal bleeding in AIDS patients secondary to Histoplasma and Cytomegalovirus infection. Int. J. Surg. Case Rep. 2016, 25, 128–131. [Google Scholar] [CrossRef] [Green Version]
  111. Martin-Iguacel, R.; Kurtzhals, J.; Jouvion, G.; Nielsen, S.D.; Lubre, J.M. Progressive Disseminated Histoplasmosis in the HIV population in Europe in the HAART era. Case Report and Literature review. Infection 2014, 42, 611–620. [Google Scholar] [CrossRef] [PubMed]
  112. Engelmann, E.W.M.; Poshuma, J.J.; Scholten, L.; Blankensteijn, L.L.; Boldewijn, M.B.; Gooszen, J.A.H. Gastrointestinal histoplasmosis mimicking peritonitis carcinomatosis: A rare case of an emergent surgical presentation of HIV de novo. J. Surg. Case Rep. 2019, 10, rjz260. [Google Scholar] [CrossRef] [PubMed]
  113. Outerelo, C.; Nortadas, R.; Gouveia, R.; Mateus, A.; Pedro, C.; Oliveira, C.; Ilgenfritz, R.B.; Ramos, A. Gastrointestinal presentation of disseminated histoplasmosis in a transplant recipient. Port. J. Nephrol. Hypert. 2012, 26, 213–216. [Google Scholar]
  114. Matulionyte, R.; Garbino, J.; Uçkay, I.; Lambert, J.F.; Hirschel, B. Disseminated histoplasmosis in an HIV-infected patient discovered by routine blood smear staining. Eur. J. Clin. Microbiol. Infect. Dis. 2005, 24, 361–363. [Google Scholar] [CrossRef]
  115. Doleschal, B.; Rodhammer, T.; Tsybrovskyy, O.; Aichberger, K.J.; Lang, F. Disseminated Histoplasmosis: A Challenging Differential Diagnostic Consideration for Suspected Malignant Lesions in the Digestive Tract. Case Rep. Gastroenterol. 2016, 10, 653–660. [Google Scholar] [CrossRef] [PubMed]
  116. Agrawal, N.; James, D.E.J.; Dyson, J.K.; Hoare, T.; Melmore, S.A.; Needham, S.; Thompson, N.P. Fatal Gastrointestinal Histoplasmosis 15 years after orthotopic Liver Transplantation. World J. Gastroenterol. 2017, 23, 7807–7812. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  117. Peppa, D.; Plumb, J.; Parca, J.D.; Taylor, S.; Miller, R.F. Gastrointestinal Histoplasmosis in an HIV infected patient living in a non-endemic area. Int. J. STD AIDS 2008, 19, 864–965. [Google Scholar] [CrossRef]
  118. Van Welzen, B.J.; Van Erpecum, K.J.; Haas, P.J.; ten Kate, F.J.; Mudrikova, T. Severe Cholestasis due to disseminated histoplasmosis under adalimumab-containing Immunosuppression Therapy. Clin. Res. Hepatol. Gastroenterol. 2013, 37, 105–107. [Google Scholar] [CrossRef]
  119. Etiva, E.; Vasquez, J.; Frisancho, O.; Yora, M.; Yabar, A. Colonic Histoplasmosis as a diagnostic manifestion of AIDS. Rev. Gastroenterol. Peru 2010, 30, 163–166. [Google Scholar]
  120. Khandwalla, H.; Gould, M. Snakelike lesions in the Colon. Clin. Gastroenterol. Hepatol. 2013, 11, A32. [Google Scholar] [CrossRef]
  121. Zamora, J.A.G.; Espinoza, L.A. Histoplasma and Cytomegalovirus Coinfection in a patient with AIDS: A Case Report and Review of the literature. Diseases 2017, 5, 30. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  122. MacIsaac, M.B.; Fehily, S.R.; Muhi, S.; Yang, L.; McKelvie, P.A.; Jeremiah, C.; Demediuk, B. Disseminated Histoplasmosis in a patient with Crohn’s disease on dual immunosuppression. St. Vincent Hosital Melb. Vic. 2019, 20, 429–430. [Google Scholar] [CrossRef] [PubMed]
  123. Kok, J.; Chen, S.C.A.; Anderson, L.; Berglund, L.; Sleiman, S.; Moss, A.; Bourke, M.; Fulcher, D.; Gilroy, N.; Sharon, C.A. Protein-losing enteropathy and hypogammaglobulinaemia as first manifestations of disseminated histoplasmosis coincident with Nocardia infection. J. Med. Microbiol. 2010, 59, 610–613. [Google Scholar] [CrossRef] [Green Version]
  124. Ehui, E.; Doukoure, B.; Kolia-Diafouka, P.; Aoussi, E.; Koffi, E.; Doumbia, A.; Kouadio, K.; Eholié, S.; Bissagnéné, E. Intestinal Histoplasmosis with Histoplasma duboisii in a Patient infected by HIV-1 in Abidjan (Ivory Coast). AIDS Clin. Res. 2011, 2, 5. [Google Scholar] [CrossRef] [Green Version]
  125. Oladele, R.O.; Osaigbovo, I.I.; Akanmu, A.; Adekanmbi, O.A.; Ekeng, B.E.; Yahayah, M.; Alex-Wele, M.A.; Okolo, M.O.; Ayanbeku, S.T.; Unigwe, U.S.; et al. Prevalence of histoplasmosis among persons with Advanced HIV disease. Nigeria. Emerg. Infect. Dis. 2022, 28, 2261–2269. [Google Scholar] [CrossRef] [PubMed]
  126. Ocansey, B.K.; Otoo, B.; Asamoah, I.; Ganu, V.; Berko, K.P.; Oladele, O.; Amankwa, E.A.; Opoku-Asare, B.; Agyei, M.; George, L.; et al. Cryptococcal and Histoplasma Antigen Screening Among People with Human Immunodeficiency Virus in Ghana and Comparative Analysis of OIDx Histoplasma Lateral Flow Assay and IMMY Histoplasma Enzyme Immunoassay. Open Forum Infect. Dis. 2022, 9, ofac277. [Google Scholar] [CrossRef]
  127. Kuate, M.P.N.; Nyasa, R.; Mandengue, C.; Tendongfor, N.; Bongomin, F.; Denning, D.W. Screening for acute disseminated histoplasmosis in HIV disease using urinary antigen detection enzyme immunoassay: A pilot study in Cameroon. J. Microbiol. Methods 2021, 185, 106226. [Google Scholar] [CrossRef] [PubMed]
  128. Obonna, G.; Arowolo, A.; Agbakwuru, A. Experience with Colonoscopy in the Riverine South Western Nigeria. J. West Afr. Coll. Surg. 2012, 2, 80–90. [Google Scholar] [PubMed]
  129. Oluwole, O.; Onyedika, O.; Badejo, O. Colonoscopy: Early Experience in National Hospital Abuja, Nigeria. Int. J. Gastroenterol. 2000, 2, 72–76. [Google Scholar]
  130. Elbatea, H.; Enaba, M.; Elkassas, G.; El-Kalla, F.; Elfert, A.A. Indications and outcome of colonoscopy in the middle of Nile delta of Egypt. Dig. Dis. Sci. 2011, 56, 2120–2123. [Google Scholar] [CrossRef]
  131. Mjoli, M.; Govindasamy, V.; Madiba, T.E. What is the diagnostic yield of colonoscopy in patients with a referral diagnosis of constipation in South Africa? S. Afr. J. Surg. 2017, 55, 14–18. [Google Scholar] [PubMed]
  132. Ljung, T.; Karlen, P.; Schmidt, D.; Hellström, P.M.; Lapidus, A.; Janczewska, I.; Sjöqvist, U.; Löfberg, R. Infliximab in inflammatory bowel disease: Clinical Outcome in Population based Cohort from Stockholm Country. Gut 2004, 53, 849–853. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  133. Fakhoury, M.; Negrulj, R.; Mooranian, A.; Al-Salami, H. Inflammatory Bowel disease: Clinical aspects and treatments. J. Inflamm. Res. 2014, 7, 113–120. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  134. Rawla, P.; Bandaru, S.S.; Vellipuram, A.R. Review of infectious etiology of acute pancreatitis. Gastroenterol. Res. 2017, 10, 153–158. [Google Scholar] [CrossRef] [PubMed] [Green Version]
Life 13 00689 g001 550
Figure 1. Geographical distribution of GIH cases (2001–2021).
Figure 1. Geographical distribution of GIH cases (2001–2021).
Life 13 00689 g001
Table
Table 1. Geographical distribution of 212 cases of GIH reported across the globe (2001–2021).
Table 1. Geographical distribution of 212 cases of GIH reported across the globe (2001–2021).
RegionsCountry (Number of Cases)Number of Cases (%)No. of HIV Positive Patients (%)No. of HIV Negative Patients (%)References
North AmericaUSA (n = 67), Mexico (n = 1), Canada (n = 1), Puerto Rico (n = 1)88 (41.5%)39 (44.3)49 (55.7)[8,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62,63,64,65,66,67,68,69,70,71,72,73,74,75,76]
AsiaIndia (n = 22), China (n = 4), Taiwan (n = 1), Bangladesh (n = 1), Singapore (n = 2), Malaysia (n = 1), Japan (n = 1)32 (15.1%)7 (21.9)25 (78.1)[77,78,79,80,81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96,97,98]
South AmericaFrench Guiana (n = 65), Ecuador (n = 6), Brazil (n = 4), Peru (n = 2), Argentina (n = 1), Trinidad and Tobago (n = 1) 79 (37.3%)72 (91.1)7 (8.9)[99,100,101,102,103,104,105,106,107,108,109,110,111]
EuropeNetherlands (n = 2), United Kingdom (n = 2), Austria (n = 1), Switzerland (n = 1), Portugal (n = 1), Spain (n = 1) 8 (15.1%)3 (37.5)5 (62.5)[112,113,114,115,116,117,118,119]
Central AmericaHonduras (n = 1), Guatemala (n = 1)2 (0.9%)2 (100)-[120,121]
AustraliaAustralia (n = 2)2 (0.9%)-2 (100)[122,123]
AfricaIvory Coast (n = 1)1 (0.5%)1 (100)-[124]
Total 21212488
Table
Table 2. Comparison between GIH cases with and without HIV infection.
Table 2. Comparison between GIH cases with and without HIV infection.
CharacteristicsHIV Infection (%)No HIV Infection (%)p-Value
n = 12341 (33.3)82 (66.7)
Symptoms/findings
Abdominal pain27 (65.9)34 (41.5)0.01
Fever20 (48.8)36 (43.9)0.7
Weight loss19 (46.3)32 (39.0)0.4
Diarrhoea15 (36.6)30 (36.6)1
Passage of blood in stool9 (22.0)16 (18.2)0.8
Generalised body weakness6 (14.6)12 (19.5)0.8
Splenomegaly3 (7.3)10 (12.2)0.5
Anorexia7 (17.1)9 (11.0)0.4
Vomiting9 (22.0)9 (11.0)0.1
Night sweats6 (14.6)12 (14.6)1
Hepatomegaly4 (9.8)9 (11.0)1
Nausea10 (24.4)9 (11.0)0.07
Jaundice2 (4.9)4 (4.9)1
Dysphagia1 (2.4)2 (2.4)1
Haematemesis1 (2.4)2 (2.4)1
Odynophagia4 (9.8)2 (2.4)0.09
Constipation1 (2.4)2 (2.4)1
Anal lesion2 (4.9)2 (2.4)0.6
Bloating01 (1.2)1
Site of infection
Colon19 (46.3)35 (42.7)0.7
Small bowel16 (39.0)20 (24.4)0.1
Gastric cavity5 (12.2)6 (7.3)0.5
Oesophagus5 (12.2)7 (8.5)0.5
Liver5 (12.2)14 (17.1)0.3
Gall bladder2 (4.9)6 (7.3)0.6
Pancreas04 (4.9)0.3
Anus02 (2.4)0.6
Complications
Gastrointestinal bleeding11 (26.8)18 (22)0.7
Hepatitis5 (12.2)14 (17.1)0.6
Intestinal Obstruction7 (17.1)8 (9.8)0.3
Cholecystitis2 (4.9)5 (6.1)1
Acute pancreatitis04 (4.9)0.3
Acute abdomen2 (4.9)2 (1.6)0.6
Bowel perforation7 (17.1)5 (6.1)0.1
Mode of diagnosis
Histopathology37 (90.2)72 (87.8)0.8
Urinary H. capsulatum antigen7 (17.1)14 (17.1)1
Culture6 (14.6)11 (13.4)1
Serum H. capsulatum antibody2 (4.9)2 (2.4)0.6
Serum H. capsulatum antigen1 (2.4)7 (8.5)0.3
H. capsulatum real-time PCR2 (4.9)3 (3.7)1
Table
Table 3. Endoscopic findings.
Table 3. Endoscopic findings.
CharacteristicsHIV Infection (%)No HIV Infection (%)p-Value
n = 8428 (33)56 (66.7)
Site of involvementUlcers
Caecum9 (32.1)4 (7.1)0.008
Ascending colon2 (7.1)7 (12.5)0.7
Transverse colon3 (10.7)4 (7.1)0.7
Descending colon1 (3.6)00.3
Sigmoid colon2 (7.1)2 (3.6)0.6
Rectum1 (3.6)6 (10.7)0.4
Entire colon07 (12.5)0.09
Undefined1 (3.6)6 (10.7)0.4
Terminal ileum8 (28.6)9 (16.1)0.2
Duodenum2 (7.1)2 (3.6)0.6
Oesophagus3 (10.7)2 (3.6)0.3
Gastric cavity3 (10.7)2 (3.6)0.3
Erythematous mucosa /Inflammation
Caecum02 (3.6)0.6
Ascending colon1 (3.6)1 (1.8)1
Transverse colon03 (5.4)0.5
Descending colon01 (1.8)1
Sigmoid colon01 (1.8)1
Rectum02 (3.6)0.6
Entire colon02 (3.6)0.6
Undefined00-
Terminal ileum02 (3.6)0.6
Duodenum1 (3.6)00.3
Oesophagus1 (3.6)4 (7.1)0.7
Gastric cavity2 (7.1)4 (7.1)1
Nodular/Polypoid
Caecum2 (7.1)5 (8.9)1
Ascending colon2 (7.1)3 (5.4)1
Transverse colon2 (7.1)1 (1.8)0.3
Descending colon1 (3.6)00.3
Sigmoid colon3 (10.7)1 (1.8)0.1
Rectum02 (3.6)0.6
Entire colon00-
Undefined04 (7.1)0.3
Terminal ileum02 (3.6)0.6
Duodenum2 (7.1)00.1
Oesophagus1 (3.6)00.3
Gastric cavity00-
n = total number of patients that had an endoscopic procedure.
Table
Table 4. Summary of treatment and outcomes.
Table 4. Summary of treatment and outcomes.
TreatmentNumber of CasesFavourable OutcomeDeath
AmB + Azoles7070-
AmB alone1165
LAmB11-
LAmB + Azoles11-
Azole monotherapy29281
Azole + Terbinafine11-
Surgery22-
AmB + Surgery1-1
Azole + Surgery11-
AmB + Antiviral medications211
Total1191118
AmB; amphotericin B, LAmB; liposomal amphotericin B.
Disclaimer/Publisher’s Note: The statements, opinions and data contained in all publications are solely those of the individual author(s) and contributor(s) and not of MDPI and/or the editor(s). MDPI and/or the editor(s) disclaim responsibility for any injury to people or property resulting from any ideas, methods, instructions or products referred to in the content.

Share and Cite

MDPI and ACS Style

Ekeng, B.E.; Itam-Eyo, A.E.; Osaigbovo, I.I.; Warris, A.; Oladele, R.O.; Bongomin, F.; Denning, D.W. Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021. Life 2023, 13, 689. https://doi.org/10.3390/life13030689

AMA Style

Ekeng BE, Itam-Eyo AE, Osaigbovo II, Warris A, Oladele RO, Bongomin F, Denning DW. Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021. Life. 2023; 13(3):689. https://doi.org/10.3390/life13030689

Chicago/Turabian Style

Ekeng, Bassey E., Asa E. Itam-Eyo, Iriagbonse I. Osaigbovo, Adilia Warris, Rita O. Oladele, Felix Bongomin, and David W. Denning. 2023. "Gastrointestinal Histoplasmosis: A Descriptive Review, 2001–2021" Life 13, no. 3: 689. https://doi.org/10.3390/life13030689

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop