Next Article in Journal / Special Issue
Changes in Tongue Area, Pharyngeal Area, and Pharyngeal Airway Velocity after Correction of Mandibular Prognathism
Previous Article in Journal
Extent of Cardiac Damage and Mortality in Patients Undergoing Transcatheter Aortic Valve Implantation
Previous Article in Special Issue
Medication-Related Osteonecrosis of the Jaw: A Critical Narrative Review
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JCM
Volume 10
Issue 19
10.3390/jcm10194565
jcm-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles thumb_up
...
Endorse textsms
...
Comment
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Article

Intraosseous Venous Malformation of the Zygomatic Bone: Comparison between Virtual Surgical Planning and Standard Surgery with Review of the Literature

by
Raúl Antúnez-Conde
1,
Carlos Navarro Cuéllar
1,*,
José Ignacio Salmerón Escobar
1,
Alberto Díez-Montiel
1,
Ignacio Navarro Cuéllar
1,
Giovanni Dell’Aversana Orabona
2,
José Luis del Castillo Pardo de Vera
3,
Carlos Navarro Vila
1 and
José Luis Cebrián Carretero
3
1
Maxillofacial Surgery Department, Hospital General Universitario Gregorio Marañón, 28009 Madrid, Spain
2
Maxillofacial Surgery Department, Università “Federico II”, 80131 Naples, Italy
3
Maxilofacial Surgery Department, Hospital Universitario La Paz, 28046 Madrid, Spain
*
Author to whom correspondence should be addressed.
J. Clin. Med. 2021, 10(19), 4565; https://doi.org/10.3390/jcm10194565
Submission received: 2 August 2021 / Revised: 22 September 2021 / Accepted: 22 September 2021 / Published: 30 September 2021
(This article belongs to the Special Issue New Perspectives in Maxillo-Facial Surgery)
Browse Figures
Versions Notes

Abstract

:
Intraosseous venous malformations affecting the zygomatic bone are infrequent. Primary reconstruction is usually accomplished with calvarial grafts, although the use of virtual surgical planning, cutting guides and patient-specific implants (PSI) have had a major development in recent years. A retrospective study was designed and implemented in patients diagnosed with intraosseous venous malformation during 2006–2021, and a review of the scientific literature was also performed to clarify diagnostic terms. Eight patients were treated, differentiating two groups according to the technique: four patients were treated through standard surgery with resection and primary reconstruction of the defect with calvarial graft, and four patients underwent resection and primary reconstruction through virtual surgical planning (VSP), cutting guides, STL models developed with CAD-CAM technology and PSI (titanium or Polyether-ether-ketone). In the group treated with standard surgery, 75% of the patients developed sequelae or morbidity associated with this technique. The operation time ranged from 175 min to 210 min (average 188.7 min), the length of hospital ranged from 4 days to 6 days (average 4.75 days) and the postoperative CT scan showed a defect surface coverage of 79.75%. The aesthetic results were “excellent” in 25% of the patients, “good” in 50% and “poor” in 25%. In the VSP group, 25% presented sequelae associated with surgical treatment. The operation time ranged from 99 min to 143 min (average 121 min), the length of hospital stay ranged from 1 to 2 days (average of 1.75 days) and 75% of the patients reported “excellent” results. Postoperative CT scan showed 100% coverage of the defect surface in the VSP group. The multi-stage implementation of virtual surgical planning with cutting guides, STL models and patient-specific implants increases the reconstructive accuracy in the treatment of patients diagnosed with intraosseous venous malformation of the zygomatic bone, reducing sequelae, operation time and average hospital stay, providing a better cover of the defect, and improving the precision of the reconstruction and the aesthetic results compared to standard technique.

1. Introduction

Intraosseous vascular anomalies are uncommon [1], representing between 0.5–1% of intraosseous tumors [2]. More atypical are intraosseous vascular malformations involving the face, with 155 cases described in the scientific literature to date. The intraosseous involvement of the zygomatic bone is exceptional, with 64 cases published in the literature; of these, only 13 cases were venous malformations. It is common to find the indistinct use of both terms in the scientific literature, hemangioma and vascular malformation, as the terminology has not been standardized [3,4,5]. The treatment of these lesions comprises complete resection of the lesion and immediate reconstruction of the defect. The most common method used to reconstruct the defect is the use of an autologous bone graft, which provides good results. The increasing demand for aesthetic results as well as the improvement and refinement of procedures and techniques has enabled the application of virtual surgical planning to this field of facial surgery. Virtual surgical planning (VSP), the development of cutting guides using stereolithographic models (STL) and computer-assisted design and manufacturing (CAD-CAM) technology with a patient-specific implant (PSI) provide more predictable and accurate results [6].
The aim of the study was to compare the results achieved through standard surgery reconstructed with calvarial graft and VSP, CAD-CAM technology, STL models and a PSI. The specific aims were: (1) to compare the sequelae and complications with both techniques; (2) to evaluate the aesthetic results; (3) to compare the surgical time and mean hospital stay; (4) to compare the defect surface coverage through postoperative CT scan; (5) to review the literature in order to describe the usual presentation, study and treatment of these venous lesions and to clarify the diagnostic terms.

2. Materials and Methods

To address the research purpose, the authors designed and implemented a retrospective study with eight patients diagnosed with intraosseous venous malformation in the zygomatic bone between 2006 and 2021 at Hospital General Universitario Gregorio Marañon and Hospital Universitario La Paz, Madrid, Spain. Eight patients were diagnosed with intraosseous venous malformation and treated with complete resection and primary reconstruction. Four patients were reconstructed with calvarial bone graft (standard technique), and four patients were treated through VSP, cutting guides, STL models and PSI. The inclusion criteria were: (1) patients with a diagnosis of vascular malformation affecting the zygomatic bone; (2) patients reconstructed with standard technique with calvarial graft; (3) patients treated through VSP, STL models, cutting guides and PSI. The exclusion criteria were: (1) patients with prior surgery or surgical sequelae affecting the zygomatic region; (2) patients with vascular malformation with multiple involvement of several facial bones and/or extensive soft tissue involvement. The follow-up ranged from 2 years to 15 years. This study followed the Declaration of Helsinki on medical protocol and the study and review of the medical records, data collection and the subsequent analysis are endorsed by the Hospital Ethics Committee (protocol code maxilohgugm 04/2020).
All cases were studied by MRI and CT. In addition, in two cases, the study was completed by arteriography due to the high risk of bleeding. There was no tumor blush susceptible to embolization. In the group treated with standard surgery, four patients were reconstructed by means of a calvarial graft obtained in the same surgical procedure through a parietal approach after the zygomatic tumor had been resected. The malar bone defect was measured in the operative field and the calvarial graft was modeled to fit the defect. The graft was fixed with miniplates. During the first postoperative month, a CT scan was performed in all patients. Four patients were treated using VSP for the osteotomies design, cutting guides, STL models and titanium or polyether-ether ketone (PEEK) PSI. CT and MRI were performed for the preoperative study in all patients. In one patient, arteriography was performed without identifying any vessel suitable for embolization. A 3D reconstruction was obtained through preoperative CT scan and a remote connection was established with the engineering team (Maffinter Med.©, Madrid, Spain). The osteotomy cutting guides were designed using CAD-CAM technology manufactured with a computer numerical control (CNC) milling machine (Maffinter Med.©, Madrid, Spain). A surface and volume measurement of the bone defect secondary to resection was performed on the virtual model, and a custom-made titanium or PEEK prosthesis was designed for each patient. Special care was taken to ensure the correct fit, avoiding irregular edges or protrusions that could compromise the patient’s comfort or esthetic results. The optimal fit of the bone cutting guides and the PSI (Maffinter Med.©, Madrid, Spain) was checked on printed STL models. A subciliary approach was performed in two cases and subciliary and hemicoronal approach in two other patients. After exposure of the tumor, the osteotomy guides were adapted and tumor resection was performed with a piezoelectric scalpel. The PSI was adapted to the defect with excellent fit in all cases. It was fixed with titanium screws according to the manufacturer’s instructions. There was no evidence of irregular surfaces or inadequate adjustment in the treated cases. A control CT scan was performed during the first postoperative month.
The variables evaluated in this study were:
  • Defect surface coverage through postoperative CT scan: the Radiodiagnostic Department compared the defect covered with a patient-specific implant in the VSP group and the defect covered with a calvarial graft in the standard technique group to assess precision and accuracy of both reconstructions. Phillips IntelliSpace Portal V.11.1 software was used to calculate the defect after resection of the malformation and the percentage coverage obtained after reconstruction.
  • Operation time and length of hospital stay between both techniques.
  • Aesthetic result: aesthetic assessment was subjectively addressed by the patients regarding facial symmetry, facial scaring and facial projection and comparing the affected side with the non-affected side. The results were classified with scores 0 (poor), 1 (good) and 2 (excellent).
  • Sequelae and complications with both techniques.

Review of the Literature

In order to establish the number of cases published in the literature with a diagnosis of zygomatic venous malformation of the zygomatic bone and to determine the most common surgical treatment, a review of the literature was performed. A complete search of reported cases, such as intraosseous vascular malformation and intraosseous hemangiomas of the facial skeleton, was performed in PubMed. Due to the indistinct use of terminology, the search was performed including the keywords “hemangiomas” and “vascular malformations”, which included venous malformations. A large number of cases have been reported interchangeably with one diagnosis or another due to the lack of immunohistochemical studies of the lesion endothelium. The search was carried out with the following algorithms:
  • hemangiomas: (intraosseous [Title] OR mandibular [Title] OR osseous [Title] OR central [Title]) AND (hemangioma [Title] OR hemangiomas [Title]) AND (face [Title] OR midface [Title] OR facial [Title] OR zygomatic [Title] OR zygoma [Title] OR malar [Title] OR maxilla [Title] OR maxillary [Title] OR orbital [Title] OR orbit [Title] OR mandible [Title] OR jaw [Title] OR jaws [Title] OR bone [Title]).
  • vascular malformations: (intraosseous [Title] OR mandibular [Title] OR osseous [Title] OR central [Title]) AND (malformation [Title] OR malformations [Title]) AND (arteriovenous [Title] OR venous [Title] OR vascular [Title]) AND (face [Title] OR midface [Title] OR facial [Title] OR zygomatic [Title] OR zygoma [Title] OR malar [Title] OR maxilla [Title] OR maxillary [Title] OR orbital [Title] OR orbit [Title] OR mandible [Title] OR jaw [Title] OR jaws [Title] OR bone [Title]).
The selected cases were filtered manually, eliminating articles related to single soft tissue involvement, publications of pathological or radiological interest without the contribution of clinical cases. A subgroup of venous malformations was also established (Appendix A). From each selected case, the following information was extracted: age, sex, location and size of the lesion, history of pain, ophthalmological alterations, history of trauma, radiological findings, surgical treatment, surgical approach, bleeding, type of reconstruction, performing immunohistochemical techniques, definitive diagnosis, follow-up and recurrence.

3. Results

3.1. Characteristics of the Sample

Eight patients underwent surgical treatment with a diagnosis of intraosseous vascular malformation located in the zygomatic bone. Four patients were treated surgically by standard technique in which reconstruction of the bone defect was performed with calvarial graft. Four patients received surgical treatment through VSP, CAD-CAM technology, STL models and PSI. In this group, two patients were reconstructed with titanium implants and two patients were reconstructed with PEEK implants indistinctly.
The mean age of the patients was 46.5 years. The average age of patients treated with standard surgery was 44.5 years and the average age for the group treated through virtual surgical planning was 48.5 years. Two patients reported pain as a symptom. All cases were studied with MRI and CT scans, although in two cases the study was completed with arteriography due to the possibility of a large diameter vessel that could be embolized prior to surgery. In all cases, CT scan showed a sclerotic tumor with a trabecular bone “honeycomb” pattern. The MRI findings consisted of a slightly expansive bone lesion hypointense in sequences enhanced in T1 and presented heterogeneous hyperintensity with hypointense areas in relation to thickened bone trabeculae in the T2 turbo spin-echo sequence. In the dynamic study T1, after the administration of contrast medium, a signal curve with progressive time-increase was identified in all cases. All this was suggestive of vascular malformation of low grade and venous nature in all the patients included in the study. In six patients, the resection was performed with a piezoelectric scalpel to minimize the risk of bleeding. In five patients, a combined hemicoronal and subciliary approach was used for tumor exposure, and in two cases, it was necessary to perform only a subciliary approach. One patient required a subciliary approach with a lateral canthotomy to provide complete resection of the malformation. At the end of the follow-up period, no local recurrence was observed in any patient.

3.2. Outcomes in Patients Treated by Means of Standard Surgery

In the group treated with standard surgery (Table 1), reconstruction was performed using a double calvarial graft harvested in the same surgical procedure through a hemicoronal approach when the zygomatic tumor had been resected. The malar bone defect was measured intraoperatively and the calvarial graft was modeled to reconstruct the defect. The average operation time for this group of patients was 188.7 min (range 175–210) (Figure 1). The average hospital stay was 4.75 days (range 4–6) (Figure 2). Postoperative CT scan showed a defect surface coverage of 79.75% (71–87) (Figure 3). No recurrences were observed during follow-up. The patients presented a scar on the scalp secondary to the harvesting of the calvarial graft as a sequela. In one patient (25%), lagophthalmos resulted as a sequela caused by the approach, which was corrected by canthopexy in a second surgical procedure. In one patient, a lateronasal incision was combined with a subciliary approach and lateral canthotomy. In another patient (25%), several months after surgery, the osteosynthesis material was partially removed due to discomfort reported by the patient. In all cases, the resected specimen was analyzed and an immunohistochemical study was performed with the result of intraosseous venous malformation. The aesthetic result was reported as excellent in one patient, good in two patients and poor in one patient.

3.3. Outcomes in Patients Treated by Means of VSP, CAD-CAM, STL Models and PSI

In the group of patients treated through VSP (Table 2), a surface and volume measurement of the bone defect secondary to the resection was performed on the virtual model, and a customized, patient-specific implant was designed for each patient. The optimal fit of the bone cutting guides and the PSI was checked on printed STL models. Subciliary approach was performed in two cases and the subciliary and hemicoronal approach in two patients. The average operation time was 121 min (range 99–143) (Figure 1). The average hospital stay was 1.75 days (range 1–2) (Figure 2). Postoperative CT scan showed 100% coverage of the defect surface (Figure 3). The esthetic results were reported as excellent in three patients and good in one patient. One patient developed a paresis of the frontal branch of the facial nerve due to possible accidental damage during the surgical approach. Histological and immunohistochemical analysis revealed an intraosseous venous malformation in all cases.

3.4. Case Presentation

  • Case Presentation 1 for Figure 4: VSP, Cutting Guides, STL Models, PEEK PSI.
  • Case Presentation 2 for Figure 5: VSP, Cutting Guides, STL Models, Titanium PSI.
  • Case Presentation 3 for Figure 6: Standard Surgery and Reconstruction with Calvarial Graft.

3.5. Literature Review and Clarification on Diagnostics Terms

With the screening of the data, it has been possible to establish that the most frequent anatomical presentation of intraosseous vascular malformations, within the facial skeleton, was the jaw, which accounts for two-thirds of all cases. The second site of involvement was the zygomatic bone, followed by maxillary, frontal, and other locations. Among the 64 cases affecting the zygomatic bone, only 13 were venous malformations (Appendix A); the distribution by sex showed a predominance of the female sex (females, 46; males, 18), representing almost 64% of the total. The prevalence was 3:1 in women. The age range of the patients included in the review was from 1 month to 73 years; the presentation was more frequent during the fourth decade of life. In the subgroup of venous malformations, the predominance was also female sex (females, 10; males, 13), with a range age from 15 to 66 years. There was a prior history of trauma in 14% of the patients (9 cases) and in 15% of patients diagnosed with venous malformation; it is necessary to clarify that in 35 of the remaining cases, a history of trauma was ruled out and, in another 21 cases, the patient was unaware of it or did not report it. The average time of development of the lesion was 25.7 months in general and 19.4 months for the subgroup of venous malformations. Almost 37% of the patients (22 cases) reported pain at the time of examination, although in some cases, it was described as “discomfort”. Nine patients (14%) previously presented ophthalmologic changes as a consequence of the tumor. Most patients, however, were asymptomatic. In the subgroup of venous malformations, there was a history of pain in 38% of the cases (five patients). There was a history of trauma in 15% of the cases (two patients). The most requested imaging test for the evolution of the lesions was CT, present in more than 70% of the cases. MRI was described in nine patients (14%), all of them after 2001.
The most frequent histologic diagnosis was hemangioma (79.6%, 51 cases). By subgroups, 31 hemangiomas, 15 cavernous hemangiomas, 4 capillary hemangiomas and 2 “mixed” cases were described. The diagnosis of venous malformation was reported in 13 cases (21.8%). Of the total cases in the literature review, only three cases (4.6%) specified histologic study and immunohistochemical techniques.
As for treatment, complete excision of the lesion was the gold standard (55 cases, 86%). An incisional biopsy was performed in eight cases, but in six of them, it was extended to complete excision. One patient refused surgical treatment. Among the patients operated by resection or excision, 78% (43 cases) underwent primary reconstruction; 26 cases received an autologous bone graft: calvarial graft (42%, 18 cases), iliac crest (11.6%, 5 cases) and rib (7.3%, 3 cases). In one patient (1.5%), reconstruction was performed with a radial osteofascial free flap. Only four cases (6%) received a specific implant customized for reconstruction. Two of them consisted of alloplastic implants: methylmethacrylate and polyetheretheretherketone (PEEK) implants, respectively (Figure 7). In the third patient, a specific titanium implant was fitted, but the authors have not reflected the surgical sequence or the type of planning. Another patient was reconstructed with a titanium PSI with good results and a description of the technique. The highest frequency of bleeding has been observed in cases who underwent biopsy (14%, nine cases) with respect to intraoperative bleeding (6.2%, four cases). No case of recurrence has been reported during the follow-up of the cases published in the literature.
The treatment used in the subgroup of venous malformation was mainly complete excision (eight patients, 61.5%). Partial resection was performed in two cases (15%), curettage of the lesion in one case (8.5%) and surveillance in two cases (15%). One case was reported with intraoperative bleeding. From 13 venous malformations, eight patients received reconstruction (Figure 8). Calvarial graft (38%, five cases) and iliac crest (7.6%, one case) were the two bone donor areas.
There was one case which received a customized alloplastic implant fixed with titanium miniplates and screws, while another patient received a titanium PSI though VSP, cutting guides developed with CAD-CAM technology and STL models.

4. Discussion

During the years 2006–2021, our group treated eight patients diagnosed with vascular malformation of the zygomatic bone. Primary reconstruction was performed in all patients. One of the objectives of this study was to compare the complications and/or sequelae associated with both techniques in patients diagnosed with vascular malformation of the zygomatic bone treated by standard technique and by VSP, CAD-CAM technology, cutting guides, STL models and PSI. In patients who underwent standard surgery, the following complications were obtained: dysesthesia of the donor area of the autologous calvarial graft (three cases, 75%), pain in the area of the intervention that required intravenous analgesic treatment during hospital stay (one case, 25%) and one case of lagophthalmos (25%). Since in this group of patients the resection was performed without cutting guides, the exposure of the surgical sites was wider to visualize the limits of the resection as well as to allow the use of different surgical tools in a small space. In one patient, lagophthalmos occurred due to the need to widen the subciliary approach by lateral canthotomy for better tumor exposure. In this patient, it was also necessary to partially remove the ostosynthesis material due to discomfort related to self-palpation. In the case in which a hemicoronal approach was required, the harvesting of the calvarial graft did not involve added morbidity. However, in the other three cases, the patients reported dysesthesia related to the donor site scar. It is necessary to clarify that, in one of the patients, there were no sequelae due to surgery, and in none of the cases recurrence of the vascular lesion was observed.
In relation to the patients treated through virtual surgery, frontal branch paresia was observed in one patient (25%) due to the hemicoronal approach, although it was transitory and complete recovery was observed 6 months after surgery. In the rest of the cases treated using VSP, CAD-CAM technology, STL models and PSI, there were no sequelae. We consider that the decrease in morbidity in this group of patients is due to: (1) a reduction in the size of the surgical wound with the advantage of better control of tumor resection by using cutting guides [7]; (2) the avoidance of an approach related to the calvarial donor site; (3) the better anatomical fit of the customized implant [8,9]. Total coverage of the defect was observed in the patients treated through VSP, cutting guides and PSI, which was also more anatomical and did not present angles or peaks that could compromise the integrity of the reconstruction [6].
Although the most frequently reported complication in the literature was intraoperative bleeding, only one case [4] out of 64 presented with a venous malformation. In our case series, it was not evident in any of the patients. This is probably due to the low flow of this type of lesion. No other complications or sequelae have been reported in the literature, which may be due to the absence of follow-up or to studies that only describe the findings of the clinical case.
The aesthetic results were good with both techniques; however, when evaluating the results observed in both groups, we found significant differences. In total, 75% of the patients who underwent virtual surgery reported an excellent esthetic result and 25% referred a good aesthetic result. These results were also assessed by the surgical team, who evaluated the result according to the presence or absence of sequelae, visible scars and facial symmetry. One patient, affected postoperatively by frontal branch paresia, assessed the esthetic result as good. After recovery of the paresia of the frontal branch of the facial nerve, the result was excellent.
In the group treated with surgery according to the standard technique, 50% of the patients (two cases) reported a good result after surgery, one patient (25%) reported a poor result and one patient (25%) reported an excellent result. The patients who reported a good result presented adequate facial aesthetics; however, they reported discomfort in the graft donor area. The patient with a poor aesthetic result had presented lagophthalmos as a sequelae of an unguided tumor resection approach and, in addition, had discomfort after reconstruction due to palpation of part of the osteosynthesis material under the skin. Additionally, in this case, we found an advantage in the use of the PSI, which, in addition to providing a more anatomical reconstruction, does not present irregular surfaces, edges or protrusions of the osteosynthesis material that could compromise the reconstruction or the patient’s comfort. [6,10].
The use of titanium PSI or PEEK PSI was indistinct. In general, polyether-ether-ether-ketone prostheses have high resistance and are biocompatible; they are radiolucent, and thus, they produce minimal artifacts on MRI. It is a lightweight material that can undergo changes during surgery with standard instruments. Titanium PSI is characterized by a higher strength and a modulus of elasticity 30 times higher than PEEK PSI. It is a radiopaque material with excellent biocompatibility and osseointegration characteristics. Due to its hardness, it is difficult to make intraoperative changes to the product supplied by the commercial manufacturer [11].
The third objective of this study was the comparison between the operation time required to perform each of the techniques and the mean hospital stay among the patients. Patients treated with standard techniques had a mean operation time of 188.7 min (range 175–210) and patients treated with VSP, cutting guides developed with CAD-CAM technology, STL and PSI models, had a mean operation time of 121 min (range 99–143). The 30% reduction in operative time was a result of faster and more precise resection using CAD-CAM cutting guides and testing on STL models after VSP. This reduction in operation time also meant a reduction in anesthesia time and potential risks [9].
The average hospital stay of patients who underwent standard surgery was 4.75 days (range 4–6); however, the average hospital stay of patients who underwent virtual surgery was 1.75 days (range 1–2). This reduction in the number of days of hospitalization was the result of the decrease in surgical morbidity, avoiding the problems derived from harvesting the calvarial bone graft. In addition, since the approach was more limited due to the greater safety of the area to be resected through the use of cutting guides, postoperative pain was reduced in all cases [6,9]. The reduction in surgical time and hospital stay resulted in considerable savings in hospital costs; however, we should not forget the costs associated with VSP, the development and manufacture of the models and cutting guides and the design and production of the customized implants [9]. Further studies should be conducted to evaluate the costs of comparing the two techniques in a specific healthcare system. These data could not be compared with other studies, since there are no specific publications on cases of zygomatic venous malformation in which surgical time has been evaluated.
The fourth objective of the study was to evaluate and compare the reconstruction of the defect after resection with each technique. For this purpose, the Radiodiagnostic Department performed a volumetric measurement of the defect developed in the zygomatic bone in the postoperative CT scan among the patients treated. The CT images were subtracted by component to measure the percentage of the defect covered by reconstruction, either PSI or calvarial graft. In all patients to be treated with VSP, CAD-CAM cutting guides and titanium or PEEK PSI, 100% defect coverage was observed. In patients treated with the standard technique, the defect created after resection was covered by 79.75% (range 71–87). The total defect coverage obtained in patients treated with VSP was a result of (1) a more precise resection through the use of cutting guides; (2) a defect with more uniform edges previously planned; (3) the verification of the good PSI fit in STL models before surgery. This correct PSI fit is one of the main advantages of treating this type of lesion using VSP, CAD-CAM-developed cutting guides, STL and PSI models, as more restricted resection defects are created, resulting in smaller surgical approaches with faster healing [6,7,8].
The last objective of our study was to review similar cases published to date and to clarify the terms used in the scientific literature for the diagnosis of vascular malformations, especially those affecting the zygomatic bone. We also reviewed the clinical presentation, study and treatment of these lesions. Thus, 155 total publications were obtained, which included intraosseous hemangiomas and intraosseous vascular malformations related to facial bones, of which 64 were involved the zygomatic bone. Among the 64 published cases, there are 24 that were exposed as vascular malformations (not specified), 27 as hemangiomas and 13 as venous malformation, although most of the earlier ones were reported an intraosseous hemangioma.
The current vascular anomalies classification was adopted by the ISSVA in 1996, incorporating the previous classification of Hamburg (1988) and based on the classification proposed by Mulliken and Glowacki in 1982 [3]. As noted, hemangiomas are proliferative lesions with a benign tumor character with a pattern of progressive growth and subsequent involution [4]. These may be childhood or congenital hemangiomas [12,13,14,15,16,17]. These lesions have a typical characteristic: their appearance is fully developed at the time of delivery, which implies that their proliferative phase has been carried out exclusively “in utero” [18,19,20].
On the contrary, vascular malformations are lesions resulting from the remainder of vascular embryological tissue, which has progressive growth without involution and may be affected by hormonal factors, such as puberty or pregnancy, undergoing accelerated growth under these circumstances [4,21,22]. Within them, venous malformations represent the most frequent peripheral vascular malformation [23]. Their origin is a congenital venous ectasia of a physiological venous territory or the abnormal development of the efferent vascular tree [24,25]. They are usually located in the head and neck (40%), extremities (40%) and trunk (20%) [21]. Many venous malformations have been incorrectly referred to as “hemangiomas”, although the growth pattern, therapeutic attitude and prognosis of both lesions are completely different [5]. Thus, they are present at birth, although they are not evident until weeks, months or years later, they do not disappear spontaneously unlike hemangiomas and they grow in parallel with the physiological development of the child.
Most of the articles about vascular malformation affecting the zygomatic bone did not present an immunohistological justification for the diagnosis provided, so it is impossible to specify whether they were really intraosseous hemangiomas, venous malformations or other vascular malformations. Moreover, before 1982, it is common to find allusions to “arteriovenous malformation” as a synonym for hemangioma [4]. Even so, there are much more recent publications with this terminology that lead to error and several articles have even been obtained in which the pathological outcome differs from the title of the manuscript. It is noteworthy that despite having the binary classification since 1982, it took 7 years to find the first case published [4,17]. Before 1996, more than 90% of cases were presented as intraosseous hemangioma. Since 1996, year of publication of ISSVA classification, the use of erratic and confusing terms affects almost half of the published cases. Although the review of the literature includes cases published since 1950, there was no diagnosis of “venous malformation” until 1991, which suggests different study techniques for the sample.
From the 64 cases of intraosseous vascular lesions of the malar bone reported in the literature, only 13 corresponded to intraosseous venous malformation of the zygomatic bone. A large number of patients have debuted with zygomatic asymmetry or bone tumor but, generally, they were asymptomatic. In the group of patients that presented symptoms, the most frequent was pain, followed by ophthalmological alterations [26,27]. There was a history of trauma in 15% of patients with venous malformations, despite having been postulated as one of the most common causes of intraosseous hemangiomas [28,29], which also leads us to believe that the erroneous terminology used in many publications may be responsible for this lack of relationship. Of the remaining cases, nine of them ruled out a history of trauma and two patients did not know. This form of clinical presentation is consistent with the patients treated by our group. However, none of the eight patients in our study had a history of trauma and two patients reported pain at the time of diagnosis. Only three of the thirteen cases published as venous malformation of the zygomatic bone were subjected to immunohistochemical study. The eight cases presented in this work were studied in this way, so the diagnosis of intraosseous venous malformation is certain.
The imaging test of choice for the study of intraosseous venous malformations is CT, being the most requested by physicians who assumed the diagnosis and treatment of reported cases (84%). This is the test is of choice because of its ability to distinguish the bone cortex from the trabecular portion more accurately than other techniques; however, it is not the most accurate when defining soft tissue involvement [2]. The most frequent descriptions of the radiographic appearance of the lesions were “honeycomb”, “soap bubbles” or “sun rays” [27,30]. MRI provides data mainly on soft tissues, but is limited to assess intraosseous lesions. In general, hyperintensity of the lesion in T1 and hypointensity in T2 can be seen, although these findings are also consistent with intraosseous lesions, such as odontogenic cysts, ameloblastoma, etc. Some authors defend its use instead of the CT, since the enhancement of the lesions in T2 provides key data in the diagnosis [31]. CT scans and MRI together with the three-dimensional reconstructions allow a more precise diagnosis of the lesion, its size and anatomical relationships. Arteriography can be used when the possibility of advantageous endovascular therapy is anticipated prior to surgery or as a definitive treatment, mainly in high-flow lesions. In the cases reviewed, selective embolization was rarely carried out, as well as in the cases of venous malformation provided, so its use seems limited [2].
Given the suspicion of vascular lesion, the biopsy is contraindicated due to the risk of bleeding, although if the involvement is soft tissue is substantial, some authors defend the possibility of performing a fine needle aspiration (FNA) [1]. In the case of the patients, the possibility of biopsy was not considered.
Contemplating the range of therapeutic options for these types of injuries in the literature, multidisciplinary management is considered the gold standard [4,32]. Surveillance may be an option in asymptomatic cases [33]. However, only two cases of venous malformation were handled in this way, and years later, they received surgical rescue due to the progressive growth of the lesion. Surgical treatment is the most adopted option by the authors, mainly through complete resection [29,33,34]. While management may differ in vascular anomalies that exclusively affect soft tissues, in intraosseous malformations, it seems to be the most appropriate option because it has shown the lowest recurrence rates. In some cases, partial resections and curettage have been performed. In cases of recurrence, complete resection was done. No recurrences have been reported of the cases that were treated by complete resection [35]. In the cases treated by our group, complete resection of the lesion was performed using piezoelectric scalpel to minimize bleeding due to the cavitation effect and to reduce the risk of associated lesion of the orbital content. The theoretical risk of soft tissue injury when performing complete resection is greater, although there have been no complications in the cases studied [36].
Regarding the ways of reconstruction, there is no consensus for the indication or the type; however, as these are resections with an important aesthetic sequel, most authors have chosen to do so. The lack of reconstruction can lead to a contraction of soft tissue that is difficult to correct with deforming sequelae [35]. Primary reconstruction is the most frequent option. Reconstruction with autologous bone is commonly used. Calvarial graft (38%, five cases) [27,29,35,36,37,38,39,40,41,42,43,44,45] and iliac crest (7.6%, one case) [1,46,47,48,49] are the two most frequent bone donor areas used; in the treatment of vascular malformations with the same location, rib (three cases) is the third most used autologous graft [50,51,52].
There is one case which received a customized alloplastic implant fixed with titanium miniplates and screws [53]. The use of custom alloplastic implants has the advantage of reducing the surgical time and eliminating morbidity in the donor area [44,53]. One patient received a titanium PSI though VSP, cutting guides developed with CAD-CAM technology and STL models [54].
The management and reconstruction methods seem to be less in venous malformations with respect to vascular malformations of the zygomatic bone in general (Figure 7 and Figure 8). This is due to the smaller number of published cases of venous malformations, since the management of both lesions is the same.
This work aims to compile all the cases published to date in the scientific literature with a diagnosis of intraosseous vascular malformation of the zygomatic bone in order to establish the diagnostic and treatment method. The investigators compare the differences between standard surgery and surgery through VSP, STL models, cutting guides and PSI. To date, although the main limitation of this study is the sample size given the low prevalence of this type of tumor in this location, this is the first comparative study of both techniques in the scientific literature. In addition, all samples obtained from patients treated by our departments have been subjected to immunohistochemistry techniques for the correct diagnosis. Therefore, further studies are required in the future to corroborate the advantages of guided surgery in a larger population.

5. Conclusions

The treatment of choice for intraosseous venous malformations involving the zygomatic bone is complete resection and primary reconstruction. It does not differ from the vascular malformations with the same location. The multistage implementation of VSP with the use of STL models, CAD/CAM cutting guides and PSI—titanium or PEEK—for zygomatic defects offers reconstructive accuracy, which previously depended on surgeon experience and intraoperative trial and error using 2D imaging modalities and autologous bone grafts. It increases resection accuracy, provides better reconstruction volume and improves operative efficiency with reduced complication rates and hospital stay. Moreover, it offers excellent aesthetic outcomes. The use of appropriate terminology, communication of clinical data between the surgeon and the pathologist and the use of immunohistochemical techniques in the processing of the specimen are necessary for the correct diagnosis and management of intraosseous vascular malformations.

Author Contributions

Conceptualization, R.A.-C. and C.N.C.; methodology, R.A.-C. and J.I.S.E.; resources, A.D.-M., I.N.C., J.L.d.C.P.d.V. and J.L.C.C. and J.L.d.C.P.d.V.; data curation, R.A.-C. and G.D.O.; writing—original draft preparation, R.A.-C.; writing—review and editing C.N.C. and C.N.V. All authors have read and agreed to the published version of the manuscript.

Funding

This research received no external funding.

Institutional Review Board Statement

The study was conducted according to the guidelines of the Declaration of Helsinki and approved by the Hospital Ethics Committee at Gregorio Marañón General Hospital, Madrid, Spain (protocol code maxilohgugm 04/20).

Informed Consent Statement

Informed consent was obtained from all subjects involved in the study.

Data Availability Statement

The data presented in this study are available on request from the corresponding author. The data are not publicly available due to data protections regulations.

Conflicts of Interest

The authors declare no conflict of interest.

Abbreviations

CAD/CAMComputer-Aided-Design/Computer-Aided-Manufacturing
CNC m.m.Computer Numerical Control milling machine
CT scanComputed tomography scan
ISSVAInternational Society for the Study of Vascular Anomalies
MRMagnetic Resonance
PEEKPolyether-Ether-Ketone
PSIPatient Specific Implant
STL modelstereolithographic model

Appendix A

Table
Table A1. Venous malformations of the zigomatic bone. M: male; F: female; R: right; L: left; Y: yes; N: no; y: year; m: month
Table A1. Venous malformations of the zigomatic bone. M: male; F: female; R: right; L: left; Y: yes; N: no; y: year; m: month
Author (Year of Publication)Age/SexSide, SizeDurationPainOcular FindingsTraumatismImagingManagementSurgical ApproachReconstructionBleedingFollow-Up, RecurrenceInmunohistochemistry
1Yueh-Bih Tang Chen et al. (1991) [38]44/FR/3 × 2 cm1 yYNNX-rays: radiolucent lesionExcisionCoronalCranial bone graftN6 y, no recurrence?
2Srinivasan et al. (2009) [8]66/FR, 3 × 3 cm4 yNNNCT: radiating spoke wheelExcision?Not requiredN2.5 y, no recurrenceGLUT-1 negative
3Defazio et al. (2012) [29]58/FR, 1 × 1.5 cm2 yNNYCT: sunburst; MRI: T2 with high signal intensityIncisional biopsy; Surveillance?Not required??GLUT-1 negative
4Defazio et al. (2012) [29]53/FR, 1 × 1.8 cm?Y?NCT and MRI consistent with dx of intraosseous venous malformationInitial incisional bi- opsy non-diagnos- tic; Surveillance; Complete resec- tion 2 y later?Split calvarial bone graft???
5Defazio et al. (2012) [29]49/MR, 1 cm6 moNNNCT: honeycombComplete resection?Split calvarial bone graft???
6Colletti et al. (2014) [27]?/F?????CT:sunburst patternEn bloc resectionLower lip incisionSplit calvarial bone graft???
7Colletti et al. (2014) [27]?/F??????En bloc resectionLower lip incisionSplit calvarial bone graft???
8Xiuling Huang (2017) [1]35/FL/2.5 × 2.5 cm7 yNNNCT: sunburst pattern of radiating trabeculae with intact corticesExcisionLower-eyelid incisionfree iliac bone graft and minititanium plateN3 y, no recurrence?
9Xiuling Huang (2017) [1]41/FL/1.5 cm2 yNNNCT: sunburst pattern of radiating trabeculae with intact corticesPartial resectionLower-eyelid incisionNN2 y, no recurrence?
10Xiuling Huang (2017) [1]44/FL/2 cm3 mYNNCT: well defined bone eminencePartially resectedlower eyelid incisionNN12 y, no recurrence?
11Xiuling Huang (2017) [1]49/FR/1 cm4 mNNNCT: well-defined radiolucency with trabecular density insideAggressive curettage?NN7 y, no recurrence?
12Zoltán Fábián et al. (2018) [4]15/ML/100 cm34 yYY, left eye dislocated to medial and cranial, mildly limited mobilityYCT: expanded zygomatic bonePreoperative embo- lization; Complete resectionWeber-Fergusson -Dieffenbach incisionPatient Specific Implant Y, during biopsy Y, moderate??
13Antúnez-Conde et al(2021) [54]55/ML/1.5 cmMany yearsYNNCT: "honeycombed osseous lesion", MRI ExcisionCoronal and subciliaryPatient Specific Implant N6 m, no recurrenceGLUT-1 negative

References

  1. Huang, X.; An, J.; Zhang, Y.; Cai, Z. Intraosseous Venous Malformations of the Zygoma: Report of 4 Cases and Literature Review. Ann. Otol. Rhinol. Laryngol. 2017, 126, 505–509. [Google Scholar] [CrossRef]
  2. Powers, D.B.; Fisher, E.; Erdmann, D. Zygomatic Intraosseous Hemangioma: Case Report and Literature Review. Cranio-Maxillofac. Trauma Reconstr. 2017, 10, 1–10. [Google Scholar] [CrossRef] [Green Version]
  3. Mulliken, J.B.; Glowacki, J. Hemangiomas and vascular malformations in infants and children: A classification based on endothelial characteristics. Plast. Reconstr. Surg. 1982, 69, 412–422. [Google Scholar] [CrossRef] [PubMed]
  4. Fábián, Z.; Szabó, G.; Petrovan, C.; Horváth, K.U.; Babicsák, B.; Hüttl, K.; Németh, Z.; Bogdán, S. Intraosseous venous malformation of the zygomatico-orbital complex. Case report and literature review with focus on confusions in vascular lesion terms. Oral Maxillofac. Surg. 2018, 22, 241–247. [Google Scholar] [CrossRef] [PubMed]
  5. Guijarro-Martínez, R.; Morales-Navarro, J.D.; Solís-García, I.; Ventura-Martínez, N.; Marqués-Mateo, M.; Puche-Torres, M. Malformación venosa intraósea primaria en hueso cigomático: Actualización en criterios diagnósticos. Rev. Esp. Cir. Oral Maxilofac. 2013, 35, 170–174. [Google Scholar] [CrossRef] [Green Version]
  6. Cuéllar, C.N.; Rial, M.T.; Antúnez-Conde, R.; Caicoya, S.O.; Cuéllar, I.N.; de Frutos, G.A.; Ángela, S.U.; Alonso, M.G.-H.; Vila, C.N.; Escobar, J.S. Virtual Surgical Planning, Stereolitographic Models and CAD/CAM Titanium Mesh for Three-Dimensional Reconstruction of Fibula Flap with Iliac Crest Graft and Dental Implants. J. Clin. Med. 2021, 10, 1922. [Google Scholar] [CrossRef] [PubMed]
  7. Thakker, J.S.; Pace, M.; Lowe, I.; Jung, P.; Herford, A.S. Virtual Surgical Planning in Maxillofacial Trauma. Atlas Oral Maxillofac. Surg. Clin. 2019, 27, 143–155. [Google Scholar] [CrossRef] [PubMed]
  8. Srinivasan, B.; Ethunandan, M.; Van Der Horst, C.; Markus, A. Intraosseous ‘haemangioma’ of the zygoma: More appropriately termed a venous malformation. Int. J. Oral Maxillofac. Surg. 2009, 38, 1066–1070. [Google Scholar] [CrossRef]
  9. Chepurnyi, Y.; Chernogorskyi, D.; Kopchak, A.; Petrenko, O. Clinical efficacy of peek patient-specific implants in orbital reconstruction. J. Oral Biol. Craniofac. Res. 2020, 10, 49–53. [Google Scholar] [CrossRef]
  10. Schlittler, F.; Vig, N.; Burkhard, J.; Lieger, O.; Michel, C.; Holmes, S. What are the limitations of the non-patient-specific implant in titanium reconstruction of the orbit? Br. J. Oral Maxillofac. Surg. 2020, 58, e80–e85. [Google Scholar] [CrossRef]
  11. Bathala, L.; Majeti, V.; Rachuri, N.; Singh, N.; Gedela, S. The Role of Polyether Ether Ketone (Peek) in Dentistry—A Review. J. Med. Life 2019, 12, 5–9. [Google Scholar] [CrossRef] [PubMed]
  12. Kilcline, C.; Frieden, I.J. Infantile Hemangiomas: How Common Are They? A Systematic Review of the Medical Literature. Pediatr. Dermatol. 2008, 25, 168–173. [Google Scholar] [CrossRef] [PubMed]
  13. Drolet, B.A.; Swanson, E.A.; Frieden, I. Infantile Hemangiomas: An Emerging Health Issue Linked to an Increased Rate of Low Birth Weight Infants. J. Pediatr. 2008, 153, 712–715.e1. [Google Scholar] [CrossRef] [PubMed]
  14. Haggstrom, A.N.; Drolet, B.A.; Baselga, E.; Chamlin, S.L.; Garzon, M.C.; Horii, K.A. Prospective Study of Infantile Heman-giomas: Demographic, Prenatal, and Perinatal Characteristics. J. Pediatr. 2007, 150, 291–294. [Google Scholar] [CrossRef]
  15. Liang, M.G.; Frieden, I.J. Infantile and congenital hemangiomas. Semin. Pediatr. Surg. 2014, 23, 162–167. [Google Scholar] [CrossRef]
  16. Dickison, P.; Christou, E.; Wargon, O. A Prospective Study of Infantile Hemangiomas with a Focus on Incidence and Risk Factors. Pediatr. Dermatol. 2011, 28, 663–669. [Google Scholar] [CrossRef]
  17. McKenna, S.J.; Roddy, S. Delayed management of a mandibular vascular malformation. J. Oral Maxillofac. Surg. 1989, 47, 517–522. [Google Scholar] [CrossRef]
  18. Boon, L.M.; Enjolras, O.; Mulliken, J.B. Congenital hemangioma: Evidence of accelerated involution. J. Pediatr. 1996, 128, 329–335. [Google Scholar] [CrossRef]
  19. Enjolras, O.; Mulliken, J.B.; Boon, L.M.; Wassef, M.; Kozakewich, H.P.; Burrows, P.E. Non involuting congenital hemangioma: A rare cutaneous vascular anomaly. Plast. Recons. Surg. 2001, 107, 1647–1654. [Google Scholar] [CrossRef] [Green Version]
  20. North, P.; Waner, M.; James, C.; Mizeracki, A.; Frieden, I.; Mihm, M.J. Congenital non progressive hemangioma: A distinct clinicopathologic entity unlike infantile hemangioma. Arch Dermatol. 2001, 137, 1607–1620. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  21. Lee, B.B.; Baumgartner, I.; Berlien, P.; Bianchini, G.; Burrows, P.; Gloviczki, P.; Huang, Y.; Laredo, J.; Loose, D.A.; Markovic, J.; et al. International Union of Phlebology (2015) Diagnosis and treatment of venous malformations. Consensus document of the International Union of Phlebology (IUP): Updated 2013. Int. Angiol. 2015, 34, 97–149. [Google Scholar] [PubMed]
  22. Fan, X.; Qiu, W.; Zhang, Z.; Mao, Q. Comparative study of clinical manifestation, plain-film radiography, and com-puted tomographic scan in arteriovenous malformations of the jaws. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2002, 94, 503–509. [Google Scholar] [CrossRef] [PubMed]
  23. McRae, M.Y.; Adams, S.; Pereira, J.; Parsi, K.; Wargon, O. Venous malformations: Clinical course and management of vascular birthmark clinic cases. Australas. J. Dermatol. 2012, 54, 22–30. [Google Scholar] [CrossRef]
  24. Nguyen, H.L.; Boon, L.M.; Vikkula, M. Genetics of vascular malformations. Semin. Pediatr. Surg. 2014, 23, 221–226. [Google Scholar] [CrossRef]
  25. Limaye, N.; Wouters, V.; Uebelhoer, M.; Tuominen, M. Somatic Mutations in the Angiopoietin- Receptor TIE2 Can Cause Both Solitary and Multiple Sporadic Venous Malformations. Nat. Genet. 2009, 41, 118–124. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  26. Kondylidou-Sidira, A.; Dietrich, E.-M.; Koloutsos, G.; Sakkas, L.; Antoniades, K. Intraosseous vascular malformation of the mandibular condyle: Presentation of a case and differential diagnosis. Oral Radiol. 2012, 28, 150–156. [Google Scholar] [CrossRef]
  27. Colletti, G.; Frigerio, A.; Giovanditto, F.; Biglioli, F.; Chiapasco, M.; Grimmer, J.F. Surgical treatment of vascular malfor-mations of the facial bones. J. Oral Maxillofac. Surg. 2014, 72, 1326.e1–1326.e18. [Google Scholar] [CrossRef]
  28. Ethunandan, M.; Mellor, T.K. Haemangiomas and vascular malformations of the maxillofacial region—A review. Br. J. Oral Maxillofac. Surg. 2006, 44, 263–272. [Google Scholar] [CrossRef]
  29. DeFazio, M.V.; Kassira, W.; Camison, L.; Meshkov, L.; Robinson, P.G.; Kawamoto, H.K.; Thaller, S.R. Intraosseous Venous Malformations of the Zygoma. Ann. Plast. Surg. 2014, 72, 323–327. [Google Scholar] [CrossRef]
  30. Moore, S.L.; Chun, J.K.; Mitre, S.A.; Som, P.M. Intraosseous Hemangioma of the Zygoma: CT and MR Findings. Am. J. Neuroradiol. 2001, 22, 1383–1385. [Google Scholar]
  31. Tokgoz, N.; Oner, Y.A.; Kaymaz, M. Primary intraosseous meningioma: CT and MRI appearance. AJNR Am. J. Neuro-Radiol. 2005, 26, 2053–2056. [Google Scholar]
  32. Ferrés-Amat, E.; Prats-Armengol, J.; Maura-Solivellas, I.; Ferrés-Amat, E.; Mareque-Bueno, J.; Ferrés-Padró, E. Gingival bleeding of a high-flow mandibular arteriovenous malformation in a child with 8-year follow-up. Case Rep. Pediatr. 2015, 2015, 745718. [Google Scholar] [CrossRef] [Green Version]
  33. Cheng, N.; Lai, D.-M.; Hsie, M.-H.; Liao, S.-L.; Chen, Y.-B.T. Intraosseous Hemangiomas of the Facial Bone. Plast. Reconstr. Surg. 2006, 117, 2366–2372. [Google Scholar] [CrossRef]
  34. Marshak, G. Hemangioma of the zygomatic bone. Arch. Otolaryngol. 1980, 106, 581–582. [Google Scholar] [CrossRef]
  35. Zins, J.E.; Turegun, M.C.; Hosn, W.; Bauer, T.W. Reconstruction of intraosseous hemangiomas of the midface using split cal-varial bone grafts. Plast. Reconstr. Surg. 2006, 117, 948–953. [Google Scholar] [CrossRef]
  36. Hamada, M.; Shimizu, H.; Takasu, A.; Nishiyama, K.; Yura, Y. Piezosurgery for intraosseous venous malformation of the mandible. Ann. Maxillofac. Surg. 2018, 8, 333–336. [Google Scholar] [CrossRef]
  37. Clauser, L.; Meneghini, F.; Riga, M.; Rigo, L. Haemangioma of the Zygoma. Report of two cases with a review of the literature. J Cranio-Maxillofac. Surg. 1991, 19, 353–358. [Google Scholar] [CrossRef]
  38. Chen, Y.-B.T.; Wornom, I.L.; Whitaker, L.A. Intraosseous Vascular Malformations of the Orbit. Plast. Reconstr. Surg. 1991, 87, 946–949. [Google Scholar] [CrossRef] [PubMed]
  39. Gil, M.C.; Navarro-Vila, C. Intraosseous hemangioma of the zygomatic bone. A case report. Int. J. Oral Maxillofac. Surg. 1992, 21, 287–291. [Google Scholar]
  40. De Ponte, F.S.; Becelli, R.; Rinna, C.; Sassano, P.P. Aesthetic and functional reconstruction in intraosseus hemangiomas of the zygoma. J. Craniofac. Surg. 1995, 6, 506–509. [Google Scholar] [CrossRef] [PubMed]
  41. Pinna, V.; Clauser, L.; Marchi, M.; Castellan, L. Haemangioma of the zygoma: Case report. Neuroradiology 1997, 39, 216–218. [Google Scholar] [CrossRef]
  42. Savastano, G.; Russo, A.; Dell’Aquila, A. Osseous hemangioma of the zygoma: A case report. J. Oral Maxillofac. Surg. 1997, 55, 1352–1356. [Google Scholar] [CrossRef]
  43. Konior, R.J.; Kelley, T.F.; Hemmer, D. Intraosseus zygomatic hemangioma. Otolaryngol. Neck Surg. 1999, 121, 122–125. [Google Scholar] [CrossRef]
  44. Ramchandani, P.L.; Sabesan, T.; Mellor, T.K. Intraosseous vascular anomaly (haemangioma) of the zygoma. Br. J. Oral Maxillofac. Surg. 2004, 42, 583–586. [Google Scholar] [CrossRef]
  45. Gómez, E.; González, T.; Arias, J.; Lasaletta, L. Three-dimensional reconstruction after removal of zygomatic intraosseous hemangioma. Oral Maxillofac. Surg. 2008, 12, 159–162. [Google Scholar] [CrossRef]
  46. Matsumiya, T.; Nemoto, H.; Kasai, Y.; Maruyama, N.; Sumiya, N. Intraosseous venous malformation of the zygoma: A case report and literature review. Int. J. Surg. Case Rep. 2015, 12, 132–136. [Google Scholar] [CrossRef] [Green Version]
  47. Har-El, G.; Hadar, T.; Zirkin, H.Y.; Sidi, J. Hemangioma of the Zygoma. Ann. Plast. Surg. 1987, 18, 533–540. [Google Scholar] [CrossRef] [PubMed]
  48. Jeter, T.S.; Hackney, F.L.; Aufdemorte, T.B. Cavernous hemangioma of the zygoma: Report of cases. J. Oral Maxillofac. Surg. 1990, 48, 508–512. [Google Scholar] [CrossRef]
  49. Pokala, A.; Devulapally, R.V.; Tejasvi, M.L.A.; Nedunooru, S. Central hemangioma of Zygoma—A rare case report with CT and MRI features. Indian J Pathol. Microbiol. 2021, 64, 334–338. [Google Scholar]
  50. Davis, E.; Morgan, L.R. Hemangioma of Bone. Arch. Otolaryngol. Head Neck Surg. 1974, 99, 443–445. [Google Scholar] [CrossRef] [PubMed]
  51. Valentini, V.; Nicolai, G.; Lorè, B.; Aboh, I.V. Intraosseous hemangiomas. J. Craniofac. Surg. 2008, 19, 1459–1464. [Google Scholar] [CrossRef]
  52. Choi, J.S.; Bae, Y.C.; Kang, G.B.; Choi, K.-U. Intraosseous hemangioma of the orbit. Arch. Craniofac. Surg. 2018, 19, 68–71. [Google Scholar] [CrossRef] [PubMed] [Green Version]
  53. Arribas-Garcia, I.; Alcala-Galiano, A.; Garcia, A.F.; Montalvo, J.J. Zygomatic intraosseous haemangioma: Reconstruction with an alloplastic prosthesis based on a 3-D model. J. Plast. Reconstr. Aesthet. Surg. 2010, 63, e451–e453. [Google Scholar] [CrossRef] [PubMed]
  54. Antúnez-Conde, R.; Salmerón, J.I.; Navarro, C. Intraosseous Venous Malformation of the Zygomatic Bone: Virtual Surgical Planning and Reconstruction With Customized CAD-CAM Titanium Implant. J. Craniofac. Surg. 2021. [Google Scholar] [CrossRef] [PubMed]
Jcm 10 04565 g001 550
Figure 1. Surgical time (minutes).
Figure 1. Surgical time (minutes).
Jcm 10 04565 g001
Jcm 10 04565 g002 550
Figure 2. Hospital stay (days).
Figure 2. Hospital stay (days).
Jcm 10 04565 g002
Jcm 10 04565 g003 550
Figure 3. Coverage of defect (percentage).
Figure 3. Coverage of defect (percentage).
Jcm 10 04565 g003
Jcm 10 04565 g004 550
Figure 4. A 42-year-old male with a history of orbital floor fracture treated surgically with titanium mesh 7 years before being diagnosed during follow-up with a vascular malformation of the right zygomatic bone (A). Virtual surgical planning was performed for resection and reconstruction with a PEEK implant. Cutting guides were designed for resection (B,C). A customized PEEK PSI was specifically designed for the reconstruction (D,E). Due to the history of orbital floor surgery with a titanium mesh, it was decided to remove it and to extend the PSI to the orbital floor to avoid possible interferences between both reconstructions. A hemicoronal approach was performed and cutting guides were used to perform the resection (F). Once the malformation was removed, the PEEK PSI was placed with an excellent fit (G). The postoperative CT scan showed a correct placement of the PEEK PSI with an optimal aesthetic result (H–J).
Figure 4. A 42-year-old male with a history of orbital floor fracture treated surgically with titanium mesh 7 years before being diagnosed during follow-up with a vascular malformation of the right zygomatic bone (A). Virtual surgical planning was performed for resection and reconstruction with a PEEK implant. Cutting guides were designed for resection (B,C). A customized PEEK PSI was specifically designed for the reconstruction (D,E). Due to the history of orbital floor surgery with a titanium mesh, it was decided to remove it and to extend the PSI to the orbital floor to avoid possible interferences between both reconstructions. A hemicoronal approach was performed and cutting guides were used to perform the resection (F). Once the malformation was removed, the PEEK PSI was placed with an excellent fit (G). The postoperative CT scan showed a correct placement of the PEEK PSI with an optimal aesthetic result (H–J).
Jcm 10 04565 g004
Jcm 10 04565 g005 550
Figure 5. A 55-year-old woman, smoker, with a history of multiple sclerosis, reported a tumor of progressive growth and pain in the left zygomatic region. After study by CT, MRI and arteriography, the patient was diagnosed with intraosseous vascular malformation in the zygomatic bone (A). Virtual surgical planning was performed for resection and reconstruction with a titanium PSI. Cutting guides were designed for resection (B,C). A customized titanium PSI was specifically designed for the reconstruction (D,E). A hemicoronal and subciliary approach were performed and cutting guides were used to perform the resection (F–H). Once the lesion was removed, the titanium PSI was placed with an excellent fit (H). The postoperative CT scan showed a correct placement of the titanium PSI with an optimal aesthetic result (I).
Figure 5. A 55-year-old woman, smoker, with a history of multiple sclerosis, reported a tumor of progressive growth and pain in the left zygomatic region. After study by CT, MRI and arteriography, the patient was diagnosed with intraosseous vascular malformation in the zygomatic bone (A). Virtual surgical planning was performed for resection and reconstruction with a titanium PSI. Cutting guides were designed for resection (B,C). A customized titanium PSI was specifically designed for the reconstruction (D,E). A hemicoronal and subciliary approach were performed and cutting guides were used to perform the resection (F–H). Once the lesion was removed, the titanium PSI was placed with an excellent fit (H). The postoperative CT scan showed a correct placement of the titanium PSI with an optimal aesthetic result (I).
Jcm 10 04565 g005
Jcm 10 04565 g006 550
Figure 6. A 55-year-old male was referred from another hospital with a suspected intraosseous vascular malformation in the right zygomatic bone. After CT and MRI studies, the diagnosis was confirmed (A). Surgical treatment was performed using standard technique with a subciliary approach with external canthotomy and lateronasal incision (B) with complete resection of the tumor and primary reconstruction by means of a calotte graft obtained in the same surgical act (C). The calotte graft was adapted to the defect and fixed by means of miniplates and ostesynthesis screws (D,E). During follow-up, the patient reported discomfort in relation to the oteosynthesis material, so it was partially removed. Moreover, he presented lagosphthalmos as sequelae of the approach (F).
Figure 6. A 55-year-old male was referred from another hospital with a suspected intraosseous vascular malformation in the right zygomatic bone. After CT and MRI studies, the diagnosis was confirmed (A). Surgical treatment was performed using standard technique with a subciliary approach with external canthotomy and lateronasal incision (B) with complete resection of the tumor and primary reconstruction by means of a calotte graft obtained in the same surgical act (C). The calotte graft was adapted to the defect and fixed by means of miniplates and ostesynthesis screws (D,E). During follow-up, the patient reported discomfort in relation to the oteosynthesis material, so it was partially removed. Moreover, he presented lagosphthalmos as sequelae of the approach (F).
Jcm 10 04565 g006
Jcm 10 04565 g007 550
Figure 7. Surgical treatment reconstruction in vascular malformations of the zygomatic bone.
Figure 7. Surgical treatment reconstruction in vascular malformations of the zygomatic bone.
Jcm 10 04565 g007
Jcm 10 04565 g008 550
Figure 8. Surgical treatment reconstruction in venous malformations of the zygomatic bone.
Figure 8. Surgical treatment reconstruction in venous malformations of the zygomatic bone.
Jcm 10 04565 g008
Table
Table 1. Patients treated by means of standard surgery—calvarial graft.
Table 1. Patients treated by means of standard surgery—calvarial graft.
Age
/Sex		Size
cm.		EvolutionClinicsAesthetic ResultHistologySequelae/
Recurrence		Surgical Time
(min.)		Coverage of Defect (%)Hospital DaysFollow-Up
Case 135/M1.510yPainGoodVascular malf.Scalp scar dysesthesia, Pain/N21071415y
Case 241/F220yNoGoodVenous malf.Scalp scar dysesthesia/N18079611y
Case 355/M110mNoPoorVenous malf.Scalp scar dysesthesia.
Lagophtalmos/N
Discomfort due to osteosynthesis material		17587510y
Case 447/F1.57yNoExcelentVenous malf.N/N1908246y
Table
Table 2. Patients who underwent VSP, CAD-CAM, STL models and PSI.
Table 2. Patients who underwent VSP, CAD-CAM, STL models and PSI.
Age
/Sex		Size
cm.		Evolu-tionClinicsAesthetic ResultHistologySequelae/
Recurrence		Surgical Time
Min.		Coverage of Defect %Hospital DaysFollow-Up
Case 155/F1.520yPainExcelentVenous malf.N/N143100%25y
Case 260/F220yNoGoodVenous malf.Frontal paresia /N124100%23y
Case 339/M12yNoExcelentVenous malf.N/N99100%13y
Case 440/F1.210yNoExcelentVenous malf.N/N118100%22y
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Share and Cite

MDPI and ACS Style

Antúnez-Conde, R.; Navarro Cuéllar, C.; Salmerón Escobar, J.I.; Díez-Montiel, A.; Navarro Cuéllar, I.; Dell’Aversana Orabona, G.; del Castillo Pardo de Vera, J.L.; Navarro Vila, C.; Cebrián Carretero, J.L. Intraosseous Venous Malformation of the Zygomatic Bone: Comparison between Virtual Surgical Planning and Standard Surgery with Review of the Literature. J. Clin. Med. 2021, 10, 4565. https://doi.org/10.3390/jcm10194565

AMA Style

Antúnez-Conde R, Navarro Cuéllar C, Salmerón Escobar JI, Díez-Montiel A, Navarro Cuéllar I, Dell’Aversana Orabona G, del Castillo Pardo de Vera JL, Navarro Vila C, Cebrián Carretero JL. Intraosseous Venous Malformation of the Zygomatic Bone: Comparison between Virtual Surgical Planning and Standard Surgery with Review of the Literature. Journal of Clinical Medicine. 2021; 10(19):4565. https://doi.org/10.3390/jcm10194565

Chicago/Turabian Style

Antúnez-Conde, Raúl, Carlos Navarro Cuéllar, José Ignacio Salmerón Escobar, Alberto Díez-Montiel, Ignacio Navarro Cuéllar, Giovanni Dell’Aversana Orabona, José Luis del Castillo Pardo de Vera, Carlos Navarro Vila, and José Luis Cebrián Carretero. 2021. "Intraosseous Venous Malformation of the Zygomatic Bone: Comparison between Virtual Surgical Planning and Standard Surgery with Review of the Literature" Journal of Clinical Medicine 10, no. 19: 4565. https://doi.org/10.3390/jcm10194565

Note that from the first issue of 2016, this journal uses article numbers instead of page numbers. See further details here.

Article Metrics

Back to TopTop