Comparable Benefits of Stingless Bee Honey and Caffeic Acid in Mitigating the Negative Effects of Metabolic Syndrome on the Brain
Abstract
:1. Introduction
2. Materials and Methods
2.1. Animals and Treatment
2.2. Fructose Solution and High-Fructose/High-Fat Diet Preparation
2.3. Stingless Bee Honey and CA Solution
2.4. Anthropometric Measurement
2.5. Brain Extraction
2.6. Serum Biochemical Analyses
2.7. ELISA Test
2.8. Immunohistology
2.8.1. EdU (5-Ethynyl-2′-deoxyuridine)
2.8.2. TUNEL Assay
2.9. Statistical Analysis
3. Results
3.1. Anthropometrical and Physiological Measurements
3.2. Serum Biochemical Analyses
3.3. ELISA Studies
3.4. Immunohistological Studies
4. Discussion
4.1. MetS Induction with HCHF Diet
4.2. Effect of SBH and CA on MetS Model
4.3. Effect of SBH and CA on Inflammatory Status and BDNF Level of MetS Model
4.4. Effect of SBH and CA on Neurogenesis and Apoptosis of Brain Cells of MetS Model
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Muhammad Abdul Kadar, N.N.; Ahmad, F.; Teoh, S.L.; Yahaya, M.F. Comparable Benefits of Stingless Bee Honey and Caffeic Acid in Mitigating the Negative Effects of Metabolic Syndrome on the Brain. Antioxidants 2022, 11, 2154. https://doi.org/10.3390/antiox11112154
Muhammad Abdul Kadar NN, Ahmad F, Teoh SL, Yahaya MF. Comparable Benefits of Stingless Bee Honey and Caffeic Acid in Mitigating the Negative Effects of Metabolic Syndrome on the Brain. Antioxidants. 2022; 11(11):2154. https://doi.org/10.3390/antiox11112154
Chicago/Turabian StyleMuhammad Abdul Kadar, Nellysha Namela, Fairus Ahmad, Seong Lin Teoh, and Mohamad Fairuz Yahaya. 2022. "Comparable Benefits of Stingless Bee Honey and Caffeic Acid in Mitigating the Negative Effects of Metabolic Syndrome on the Brain" Antioxidants 11, no. 11: 2154. https://doi.org/10.3390/antiox11112154