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N-Acetylcysteine Ameliorates 5-Fluorouracil‐Induced Ovarian Injury in Rats

Year 2023, Volume: 13 Issue: 4, 776 - 781, 29.12.2023

Elif Ayazoglu Demir Ahmet Mentese Hatice Küçük Nihal Türkmen Selim Demir Yüksel Aliyazıcıoğlu

https://doi.org/10.33808/clinexphealthsci.1199615

Abstract

Objective: Although 5-fluorouracil (5-FU) is one of the most commonly used chemotherapeutics worldwide, it has been shown that 5-FU administration can cause reproductive toxicity in recent years. N-acetylcysteine (NAC) is the precursor of glutathione, the most important endogenous antioxidant molecule and is known for its effective antioxidant and anti-inflammatory properties. Although NAC is one of the most studied antioxidant molecules, its curative effect against ovarian damage caused by 5-FU has not been demonstrated to date. It was therefore aimed to investigate whether NAC is therapeutic against 5-FU-induced ovotoxicity in this study for the first time.
Methods: Rats were first exposed to a single dose of 5-FU (100 mg/kg) and then treated with NAC (10 and 20 mg/kg) for three days. The oxidative stress, inflammation and apoptosis markers in ovarian tissues were also determined using spectrophotometric methods. Ovarian tissues were also evaluated histologically.
Results: It was revealed that the levels of oxidative stress, inflammation and apoptosis biomarkers in ovarian tissue increased by 5-FU administration (p<.005). Treatments with NAC significantly restored these damages dose-dependently (p<.005). Moreover, these biochemical findings were confirmed by histological examination.
Conclusion: NAC can be considered as a potential therapeutic molecule against 5-FU-induced reproductive toxicity, as it can abolish the ovarian toxicity caused by 5-FU by reducing oxidative stress, inflammation and apoptosis.

Keywords

5-Fluorouracil Apoptosis Inflammation N-acetylcysteine Oxidative stress Ovotoxicity

References

  • Zhang QY, Wang FX, Jia KK, Kong LD. Natural product interventions for chemotherapy and radiotherapy-induced side effects. Frontiers in Pharmacology 2018; 9: 1253. DOI: 10.3389/fphar.2018.01253.
  • Al-Hamdany MZ, Al-Hubaity AY. Protective effects of N-acetylcysteine against 5-fluorouracil-induced pulmonary toxicity in albino rats. Iraqi Journal of Medical Sciences 2019; 12(2): 139-149. DOI: 10.31351/vol32iss1pp40-44.
  • Lamberti M, Porto S, Marra M, Zappavigna S, Grimaldi A, Feola D, Pesce D, Naviglio S, Spina A, Sannolo N, Caraglia M. 5-Fluorouracil induces apoptosis in rat cardiocytes through intracellular oxidative stress. Journal of Experimental & Clinical Cancer Research 2012; 31(1): 60. DOI: 10.1186/1756-9966-31-60.
  • Helal MAM. The effects of N-acetyl-L-cysteine on the female reproductive performance and nephrotoxicity in rats. Renal Failure 2016; 38(2): 311-320. DOI: 10.3109/0886022X.2015.1127742.
  • Lambouras M, Liew SH, Horvay K, Abud HE, Stringer JM, Hutt KJ. Examination of the ovotoxicity of 5-fluorouracil in mice. Journal of Assisted Reproduction and Genetics 2018; 35: 1053-1060. DOI: 10.1007/s10815-018-1169-6.
  • Polk A, Vistisen K, Vaage-Nilsen M, Nielsen DL. A systematic review of the pathophysiology of 5-fluorouracil-induced cardiotoxicity. BMC Pharmacology and Toxicology 2014; 15: 47. DOI: 10.1186/2050-6511-15-47.
  • Stringer JM, Swindells EOK, Zerafa N, Liew SH, Hutt KJ. Multidose 5-fluorouracil is highly toxic to growing ovarian follicles in mice. Toxicological Sciences 2018; 166(1): 97-107. DOI: 10.1093/toxsci/kfy189.
  • Gunturk I, Yazici C, Kose K, Dagli F, Yucel B, Yay A. The effect of N-acetylcysteine on inflammation and oxidative stress in cisplatin-induced nephrotoxicity: A rat model. Turkish Journal of Medical Sciences 2019; 49: 1789-1799. DOI: 10.3906/sag-1903-225.
  • Kazaz IO, Demir S, Yulug E, Colak F, Bodur A, Yaman SO, Karaguzel E, Mentese A. N-acetylcysteine protects testicular tissue against ischemia/reperfusion injury via inhibiting endoplasmic reticulum stress and apoptosis. Journal of Pediatric Urology 2019; 15(3): 253.e1-253.e8. DOI: 10.1016/j.jpurol.2019.02.005.
  • Rosic G, Srejovic I, Zivkovic V, Selakovic D, Joksimovic J, Jakovljevic V. The effects of N-acetylcysteine on cisplatin-induced cardiotoxicity on isolated rat hearts after short-term global ischemia. Toxicological Reports 2015; 2: 996-1006. DOI: 10.1016/j.toxrep.2015.07.009.
  • Akbulut S, Elbe H, Eris C, Dogan Z, Toprak G, Otan E, Erdemli E, Turkoz Y. Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats. World Journal of Gastroenterology 2014; 20(29): 10158-10165. DOI: 10.3748/wjg.v20.i29.10158.
  • Elsayed A, Elkomy A, Elkammar R, Youssef G, Abdelhiee EY, Abdo W, Fadl SE, Soliman A, Aboubakr M. Synergistic protective effects of lycopene and N‑acetylcysteine against cisplatin‑induced hepatorenal toxicity in rats. Scientific Reports 2021; 11(1): 13979. DOI: 10.1038/s41598-021-93196-7.
  • Mentese A, Alemdar NT, Livaoglu A, Demir EA, Aliyazicioglu Y, Demir S. Suppression of cisplatin-induced ovarian injury in rats by chrysin: An experimental study. Journal of Obstetrics and Gynaecology 2022; 42(8): 3584-3590. DOI: 10.1080/01443615.2022.2130201.
  • Demir EA, Mentese A, Kucuk H, Alemdar NT, Demir S. p-Coumaric acid alleviates cisplatin-induced ovarian toxicity in rats. Journal of Obstetrics and Gynaecology Research 2022; 48(2): 411-419. DOI: 10.1111/jog.15119.
  • Demir EA, Mentese A, Demir S, Kucuk H, Alemdar NT, Aliyazicioglu Y. Evaluation of therapeutic effect of chrysin against 5-fluorouracil-induced ovarian damage in rats. Farabi Medical Journal 2023; 2(1): 1-7.
  • Zhang S, Liu Y, Xiang D, Yang J, Liu D, Ren X, Zhang C. Assessment of dose-response relationship of 5-fluorouracil to murine intestinal injury. Biomedicine & Pharmacotherapy 2018; 106: 910-916. DOI: 10.1016/j.biopha.2018.07.029.
  • Samuhasaneeto S, Thong-Ngam D, Kulaputana O, Patumraj S, Klaikeaw N. Effects of N-acetylcysteine on oxidative stress in rats with non-alcoholic steatohepatitis. Journal of the Medical Association of Thailand 2007; 90(4): 788-797.
  • Li WH, Wang L, He HY, Chen J, Yu YR. Expression of neutrophil gelatinase-associated lipocalin in low osmolar contrast-induced nephropathy in rats and the effect of N-acetylcysteine. Experimental and Therapeutic Medicine 2016; 12(5): 3175-3180. DOI: 10.3892/etm.2016.3779.
  • Mihara M, Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Analitical Biochemistry 1978; 86(1): 271-278. DOI: 10.1016/0003-2697(78)90342-1.
  • Ersoy GS, Eken M, Tal R, Oztekin D, Devranoglu B, Kaygusuz EI, Cevik O. N-acetylcysteine leads to greater ovarian protection than enoxaparin sodium in a rat ovarian torsion model. Reproductive BioMedicine Online 2016; 33: 93-101. DOI: 10.1016/j.rbmo.2016.03.009.
  • Demir EA, Mentese A, Livaoglu A, Alemdar NT, Demir S. Ameliorative effect of gallic acid on cisplatin-induced ovarian toxicity in rats. Drug and Chemical Toxicology 2023; 46(1): 97-103. DOI: 10.1080/01480545.2021.2011312.
  • Turan I, Demir S, Aliyazicioglu R, Kilinc K, Yaman SO, Cakiroglu KA, Kanbolat S, Demir EA, Mentese A, Aliyazicioglu Y, Deger O. Dimethyl sulfoxide extract of Dianthus carmelitarum induces S phase arrest and apoptosis in human colon cancer cells. Nutrition and Cancer 2019; 71(7): 1181-1188. DOI: 10.1080/01635581.2019.1598563.
  • Mahmoud AM, Hozayen WG, Ramadan SM. Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPAR-γ, and suppressing oxidative stress and apoptosis in rats. Biomedicine & Pharmacotherapy 2017; 94: 280-291. DOI: 10.1016/j.biopha.2017.07.101.
  • Aliyazicioglu Y, Demir S, Yaman SO, Sener SO, Demir EA, Aliyazicioglu R, Turan I. Phytochemical analysis of Dorycnium pentaphyllum and its antiproliferative effect on cervix cancer cells. KSU Journal of Agriculture and Nature 2019; 22(Suppl 2): 365-373. DOI: 10.18016/ksutarimdoga.vi.579938.
  • Demir S, Kazaz IO, Kerimoglu G, Demir EA, Colak F, Yilmaz S, Mentese A. Astaxanthin protects testicular tissue against torsion/detorsion-induced injury via suppressing endoplasmic reticulum stress in rats. Journal of Investigative Surgery 2022; 35(5): 1044-1049. DOI: 10.1080/08941939.2021.1995540.
  • Bulucu F, Ocal R, Karadurmus N, Sahin M, Kenar L, Aydin A, Oktenli C, Koc B, Inal V, Yamanel L, Yaman H. Effects of N-acetylcysteine, deferoxamine and selenium on doxorubicin-induced hepatotoxicity. Biological Trace Element Research 2009; 132: 184-196. DOI: 10.1007/s12011-009-8377-y.
  • Mansour HH, El-Kiki SM, Hasan HF. Protective effect of N-acetylcysteine on cyclophosphamide-induced cardiotoxicity in rats. Environmental Toxicology and Pharmacology 2015; 40(2): 417-422. DOI: 10.1016/j.etap.2015.07.013.
  • Kazaz IO, Demir S, Kerimoglu G, Colak F, Alemdard NT, Dogan SY, Bostan S, Mentese A. Chlorogenic acid ameliorates torsion/detorsion-induced testicular injury via decreasing endoplasmic reticulum stress. Journal of Pediatric Urology 2022; 18(3): 289.e1-289.e7. DOI: 10.1016/j.jpurol.2022.02.013.
  • Demir EA, Demir S, Kazaz IO, Kucuk H, Alemdar NT, Buyuk A, Mentese A, Aliyazicioglu Y. Arbutin abrogates testicular ischemia/reperfusion injury in rats through repression of inflammation and ER stress. Tissue and Cell 2023; 86: 102056. DOI: 10.1016/j.tice.2023.102056.
  • Abdel-Wahab WM, Moussa FI, Saad NA. Synergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats. Drug Design, Development and Therapy 2017; 11: 901-908. DOI: 10.2147/DDDT.S131316.
  • Abdel-Wahab WM, Moussa FI. Neuroprotective effect of N-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation. Drug Design, Development and Therapy 2019; 13: 1155-1162. DOI: 10.2147/DDDT.S191240.
  • Cetinkaya A, Bulbuloglu E, Kurutas EB, Kantarceken B. N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats. Medical Science Monitor 2006; 12(8): 274-278.
  • Kockar MC, Nazıroglu M, Celik O, Tola HT, Bayram D, Koyu A. N-acetylcysteine modulates doxorubicin-induced oxidative stress and antioxidant vitamin concentrations in liver of rats. Cell Biochemistry and Function 2010; 28: 673-677. DOI: 10.1002/cbf.1707.
  • Zaki SM, Mohamed EA, Motawie AG, Fattah SA. N-acetylcysteine versus progesterone on the cisplatin-induced peripheral neurotoxicity. Folia Morphologica 2018; 77(2): 234-245. DOI: 10.5603/FM.a2017.0090.
  • Luo J, Tsuji T, Yasuda H, Sun Y, Fujigaki Y, Hishida A. The molecular mechanisms of the attenuation of cisplatin-induced acute renal failure by N-acetylcysteine in rats. Nephrology Dialysis Transplantation 2008; 23: 2198-2205. DOI: 10.1093/ndt/gfn090.
  • Kang KS, Shin S, Lee SI. N-acetylcysteine modulates cyclophosphamide-induced immunosuppression, liver injury, and oxidative stress in miniature pigs. Journal of Animal Science and Technology 2020; 62(3): 348-355. DOI: 10.5187/jast.2020.62.3.348.
  • Goyal V, Bews H, Cheung D, Premecz S, Mandal S, Shaikh B, Best R, Bhindi R, Chaudhary R, Ravandi A, Thliveris J, Singal PK, Niraula S, Jassal DS. The cardioprotective role of N-acetyl cysteine amide in the prevention of doxorubicin and trastuzumab-mediated cardiac dysfunction. Canadian Journal of Cardiology 2016; 32(12): 1513-1519. DOI: 10.1016/j.cjca.2016.06.002.
  • Kurauchi K, Nishikawa T, Miyahara E, Okamoto Y, Kawano Y. Role of metabolites of cyclophosphamide in cardiotoxicity. BMC Research Notes 2017; 10(1): 406. DOI: 10.1186/s13104-017-2726-2.

Year 2023, Volume: 13 Issue: 4, 776 - 781, 29.12.2023

Elif Ayazoglu Demir Ahmet Mentese Hatice Küçük Nihal Türkmen Selim Demir Yüksel Aliyazıcıoğlu

https://doi.org/10.33808/clinexphealthsci.1199615

Abstract

References

  • Zhang QY, Wang FX, Jia KK, Kong LD. Natural product interventions for chemotherapy and radiotherapy-induced side effects. Frontiers in Pharmacology 2018; 9: 1253. DOI: 10.3389/fphar.2018.01253.
  • Al-Hamdany MZ, Al-Hubaity AY. Protective effects of N-acetylcysteine against 5-fluorouracil-induced pulmonary toxicity in albino rats. Iraqi Journal of Medical Sciences 2019; 12(2): 139-149. DOI: 10.31351/vol32iss1pp40-44.
  • Lamberti M, Porto S, Marra M, Zappavigna S, Grimaldi A, Feola D, Pesce D, Naviglio S, Spina A, Sannolo N, Caraglia M. 5-Fluorouracil induces apoptosis in rat cardiocytes through intracellular oxidative stress. Journal of Experimental & Clinical Cancer Research 2012; 31(1): 60. DOI: 10.1186/1756-9966-31-60.
  • Helal MAM. The effects of N-acetyl-L-cysteine on the female reproductive performance and nephrotoxicity in rats. Renal Failure 2016; 38(2): 311-320. DOI: 10.3109/0886022X.2015.1127742.
  • Lambouras M, Liew SH, Horvay K, Abud HE, Stringer JM, Hutt KJ. Examination of the ovotoxicity of 5-fluorouracil in mice. Journal of Assisted Reproduction and Genetics 2018; 35: 1053-1060. DOI: 10.1007/s10815-018-1169-6.
  • Polk A, Vistisen K, Vaage-Nilsen M, Nielsen DL. A systematic review of the pathophysiology of 5-fluorouracil-induced cardiotoxicity. BMC Pharmacology and Toxicology 2014; 15: 47. DOI: 10.1186/2050-6511-15-47.
  • Stringer JM, Swindells EOK, Zerafa N, Liew SH, Hutt KJ. Multidose 5-fluorouracil is highly toxic to growing ovarian follicles in mice. Toxicological Sciences 2018; 166(1): 97-107. DOI: 10.1093/toxsci/kfy189.
  • Gunturk I, Yazici C, Kose K, Dagli F, Yucel B, Yay A. The effect of N-acetylcysteine on inflammation and oxidative stress in cisplatin-induced nephrotoxicity: A rat model. Turkish Journal of Medical Sciences 2019; 49: 1789-1799. DOI: 10.3906/sag-1903-225.
  • Kazaz IO, Demir S, Yulug E, Colak F, Bodur A, Yaman SO, Karaguzel E, Mentese A. N-acetylcysteine protects testicular tissue against ischemia/reperfusion injury via inhibiting endoplasmic reticulum stress and apoptosis. Journal of Pediatric Urology 2019; 15(3): 253.e1-253.e8. DOI: 10.1016/j.jpurol.2019.02.005.
  • Rosic G, Srejovic I, Zivkovic V, Selakovic D, Joksimovic J, Jakovljevic V. The effects of N-acetylcysteine on cisplatin-induced cardiotoxicity on isolated rat hearts after short-term global ischemia. Toxicological Reports 2015; 2: 996-1006. DOI: 10.1016/j.toxrep.2015.07.009.
  • Akbulut S, Elbe H, Eris C, Dogan Z, Toprak G, Otan E, Erdemli E, Turkoz Y. Cytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats. World Journal of Gastroenterology 2014; 20(29): 10158-10165. DOI: 10.3748/wjg.v20.i29.10158.
  • Elsayed A, Elkomy A, Elkammar R, Youssef G, Abdelhiee EY, Abdo W, Fadl SE, Soliman A, Aboubakr M. Synergistic protective effects of lycopene and N‑acetylcysteine against cisplatin‑induced hepatorenal toxicity in rats. Scientific Reports 2021; 11(1): 13979. DOI: 10.1038/s41598-021-93196-7.
  • Mentese A, Alemdar NT, Livaoglu A, Demir EA, Aliyazicioglu Y, Demir S. Suppression of cisplatin-induced ovarian injury in rats by chrysin: An experimental study. Journal of Obstetrics and Gynaecology 2022; 42(8): 3584-3590. DOI: 10.1080/01443615.2022.2130201.
  • Demir EA, Mentese A, Kucuk H, Alemdar NT, Demir S. p-Coumaric acid alleviates cisplatin-induced ovarian toxicity in rats. Journal of Obstetrics and Gynaecology Research 2022; 48(2): 411-419. DOI: 10.1111/jog.15119.
  • Demir EA, Mentese A, Demir S, Kucuk H, Alemdar NT, Aliyazicioglu Y. Evaluation of therapeutic effect of chrysin against 5-fluorouracil-induced ovarian damage in rats. Farabi Medical Journal 2023; 2(1): 1-7.
  • Zhang S, Liu Y, Xiang D, Yang J, Liu D, Ren X, Zhang C. Assessment of dose-response relationship of 5-fluorouracil to murine intestinal injury. Biomedicine & Pharmacotherapy 2018; 106: 910-916. DOI: 10.1016/j.biopha.2018.07.029.
  • Samuhasaneeto S, Thong-Ngam D, Kulaputana O, Patumraj S, Klaikeaw N. Effects of N-acetylcysteine on oxidative stress in rats with non-alcoholic steatohepatitis. Journal of the Medical Association of Thailand 2007; 90(4): 788-797.
  • Li WH, Wang L, He HY, Chen J, Yu YR. Expression of neutrophil gelatinase-associated lipocalin in low osmolar contrast-induced nephropathy in rats and the effect of N-acetylcysteine. Experimental and Therapeutic Medicine 2016; 12(5): 3175-3180. DOI: 10.3892/etm.2016.3779.
  • Mihara M, Uchiyama M. Determination of malonaldehyde precursor in tissues by thiobarbituric acid test. Analitical Biochemistry 1978; 86(1): 271-278. DOI: 10.1016/0003-2697(78)90342-1.
  • Ersoy GS, Eken M, Tal R, Oztekin D, Devranoglu B, Kaygusuz EI, Cevik O. N-acetylcysteine leads to greater ovarian protection than enoxaparin sodium in a rat ovarian torsion model. Reproductive BioMedicine Online 2016; 33: 93-101. DOI: 10.1016/j.rbmo.2016.03.009.
  • Demir EA, Mentese A, Livaoglu A, Alemdar NT, Demir S. Ameliorative effect of gallic acid on cisplatin-induced ovarian toxicity in rats. Drug and Chemical Toxicology 2023; 46(1): 97-103. DOI: 10.1080/01480545.2021.2011312.
  • Turan I, Demir S, Aliyazicioglu R, Kilinc K, Yaman SO, Cakiroglu KA, Kanbolat S, Demir EA, Mentese A, Aliyazicioglu Y, Deger O. Dimethyl sulfoxide extract of Dianthus carmelitarum induces S phase arrest and apoptosis in human colon cancer cells. Nutrition and Cancer 2019; 71(7): 1181-1188. DOI: 10.1080/01635581.2019.1598563.
  • Mahmoud AM, Hozayen WG, Ramadan SM. Berberine ameliorates methotrexate-induced liver injury by activating Nrf2/HO-1 pathway and PPAR-γ, and suppressing oxidative stress and apoptosis in rats. Biomedicine & Pharmacotherapy 2017; 94: 280-291. DOI: 10.1016/j.biopha.2017.07.101.
  • Aliyazicioglu Y, Demir S, Yaman SO, Sener SO, Demir EA, Aliyazicioglu R, Turan I. Phytochemical analysis of Dorycnium pentaphyllum and its antiproliferative effect on cervix cancer cells. KSU Journal of Agriculture and Nature 2019; 22(Suppl 2): 365-373. DOI: 10.18016/ksutarimdoga.vi.579938.
  • Demir S, Kazaz IO, Kerimoglu G, Demir EA, Colak F, Yilmaz S, Mentese A. Astaxanthin protects testicular tissue against torsion/detorsion-induced injury via suppressing endoplasmic reticulum stress in rats. Journal of Investigative Surgery 2022; 35(5): 1044-1049. DOI: 10.1080/08941939.2021.1995540.
  • Bulucu F, Ocal R, Karadurmus N, Sahin M, Kenar L, Aydin A, Oktenli C, Koc B, Inal V, Yamanel L, Yaman H. Effects of N-acetylcysteine, deferoxamine and selenium on doxorubicin-induced hepatotoxicity. Biological Trace Element Research 2009; 132: 184-196. DOI: 10.1007/s12011-009-8377-y.
  • Mansour HH, El-Kiki SM, Hasan HF. Protective effect of N-acetylcysteine on cyclophosphamide-induced cardiotoxicity in rats. Environmental Toxicology and Pharmacology 2015; 40(2): 417-422. DOI: 10.1016/j.etap.2015.07.013.
  • Kazaz IO, Demir S, Kerimoglu G, Colak F, Alemdard NT, Dogan SY, Bostan S, Mentese A. Chlorogenic acid ameliorates torsion/detorsion-induced testicular injury via decreasing endoplasmic reticulum stress. Journal of Pediatric Urology 2022; 18(3): 289.e1-289.e7. DOI: 10.1016/j.jpurol.2022.02.013.
  • Demir EA, Demir S, Kazaz IO, Kucuk H, Alemdar NT, Buyuk A, Mentese A, Aliyazicioglu Y. Arbutin abrogates testicular ischemia/reperfusion injury in rats through repression of inflammation and ER stress. Tissue and Cell 2023; 86: 102056. DOI: 10.1016/j.tice.2023.102056.
  • Abdel-Wahab WM, Moussa FI, Saad NA. Synergistic protective effect of N-acetylcysteine and taurine against cisplatin-induced nephrotoxicity in rats. Drug Design, Development and Therapy 2017; 11: 901-908. DOI: 10.2147/DDDT.S131316.
  • Abdel-Wahab WM, Moussa FI. Neuroprotective effect of N-acetylcysteine against cisplatin-induced toxicity in rat brain by modulation of oxidative stress and inflammation. Drug Design, Development and Therapy 2019; 13: 1155-1162. DOI: 10.2147/DDDT.S191240.
  • Cetinkaya A, Bulbuloglu E, Kurutas EB, Kantarceken B. N-acetylcysteine ameliorates methotrexate-induced oxidative liver damage in rats. Medical Science Monitor 2006; 12(8): 274-278.
  • Kockar MC, Nazıroglu M, Celik O, Tola HT, Bayram D, Koyu A. N-acetylcysteine modulates doxorubicin-induced oxidative stress and antioxidant vitamin concentrations in liver of rats. Cell Biochemistry and Function 2010; 28: 673-677. DOI: 10.1002/cbf.1707.
  • Zaki SM, Mohamed EA, Motawie AG, Fattah SA. N-acetylcysteine versus progesterone on the cisplatin-induced peripheral neurotoxicity. Folia Morphologica 2018; 77(2): 234-245. DOI: 10.5603/FM.a2017.0090.
  • Luo J, Tsuji T, Yasuda H, Sun Y, Fujigaki Y, Hishida A. The molecular mechanisms of the attenuation of cisplatin-induced acute renal failure by N-acetylcysteine in rats. Nephrology Dialysis Transplantation 2008; 23: 2198-2205. DOI: 10.1093/ndt/gfn090.
  • Kang KS, Shin S, Lee SI. N-acetylcysteine modulates cyclophosphamide-induced immunosuppression, liver injury, and oxidative stress in miniature pigs. Journal of Animal Science and Technology 2020; 62(3): 348-355. DOI: 10.5187/jast.2020.62.3.348.
  • Goyal V, Bews H, Cheung D, Premecz S, Mandal S, Shaikh B, Best R, Bhindi R, Chaudhary R, Ravandi A, Thliveris J, Singal PK, Niraula S, Jassal DS. The cardioprotective role of N-acetyl cysteine amide in the prevention of doxorubicin and trastuzumab-mediated cardiac dysfunction. Canadian Journal of Cardiology 2016; 32(12): 1513-1519. DOI: 10.1016/j.cjca.2016.06.002.
  • Kurauchi K, Nishikawa T, Miyahara E, Okamoto Y, Kawano Y. Role of metabolites of cyclophosphamide in cardiotoxicity. BMC Research Notes 2017; 10(1): 406. DOI: 10.1186/s13104-017-2726-2.
There are 38 citations in total.

Details

Primary Language English
Subjects Medical Biochemistry - Amino Acids and Metabolites
Journal Section Articles
Authors

Elif Ayazoglu Demir 0000-0001-7188-2176

Ahmet Mentese 0000-0003-2036-5317

Hatice Küçük 0000-0002-3724-9104

Nihal Türkmen 0000-0002-8913-8692

Selim Demir 0000-0002-1863-6280

Yüksel Aliyazıcıoğlu 0000-0001-9474-4307

Publication Date December 29, 2023
Submission Date November 4, 2022
Published in Issue Year 2023 Volume: 13 Issue: 4

Cite

APA Ayazoglu Demir, E., Mentese, A., Küçük, H., Türkmen, N., et al. (2023). N-Acetylcysteine Ameliorates 5-Fluorouracil‐Induced Ovarian Injury in Rats. Clinical and Experimental Health Sciences, 13(4), 776-781. https://doi.org/10.33808/clinexphealthsci.1199615
AMA Ayazoglu Demir E, Mentese A, Küçük H, Türkmen N, Demir S, Aliyazıcıoğlu Y. N-Acetylcysteine Ameliorates 5-Fluorouracil‐Induced Ovarian Injury in Rats. Clinical and Experimental Health Sciences. December 2023;13(4):776-781. doi:10.33808/clinexphealthsci.1199615
Chicago Ayazoglu Demir, Elif, Ahmet Mentese, Hatice Küçük, Nihal Türkmen, Selim Demir, and Yüksel Aliyazıcıoğlu. “N-Acetylcysteine Ameliorates 5-Fluorouracil‐Induced Ovarian Injury in Rats”. Clinical and Experimental Health Sciences 13, no. 4 (December 2023): 776-81. https://doi.org/10.33808/clinexphealthsci.1199615.
EndNote Ayazoglu Demir E, Mentese A, Küçük H, Türkmen N, Demir S, Aliyazıcıoğlu Y (December 1, 2023) N-Acetylcysteine Ameliorates 5-Fluorouracil‐Induced Ovarian Injury in Rats. Clinical and Experimental Health Sciences 13 4 776–781.
IEEE E. Ayazoglu Demir, A. Mentese, H. Küçük, N. Türkmen, S. Demir, and Y. Aliyazıcıoğlu, “N-Acetylcysteine Ameliorates 5-Fluorouracil‐Induced Ovarian Injury in Rats”, Clinical and Experimental Health Sciences, vol. 13, no. 4, pp. 776–781, 2023, doi: 10.33808/clinexphealthsci.1199615.
ISNAD Ayazoglu Demir, Elif et al. “N-Acetylcysteine Ameliorates 5-Fluorouracil‐Induced Ovarian Injury in Rats”. Clinical and Experimental Health Sciences 13/4 (December 2023), 776-781. https://doi.org/10.33808/clinexphealthsci.1199615.
JAMA Ayazoglu Demir E, Mentese A, Küçük H, Türkmen N, Demir S, Aliyazıcıoğlu Y. N-Acetylcysteine Ameliorates 5-Fluorouracil‐Induced Ovarian Injury in Rats. Clinical and Experimental Health Sciences. 2023;13:776–781.
MLA Ayazoglu Demir, Elif et al. “N-Acetylcysteine Ameliorates 5-Fluorouracil‐Induced Ovarian Injury in Rats”. Clinical and Experimental Health Sciences, vol. 13, no. 4, 2023, pp. 776-81, doi:10.33808/clinexphealthsci.1199615.
Vancouver Ayazoglu Demir E, Mentese A, Küçük H, Türkmen N, Demir S, Aliyazıcıoğlu Y. N-Acetylcysteine Ameliorates 5-Fluorouracil‐Induced Ovarian Injury in Rats. Clinical and Experimental Health Sciences. 2023;13(4):776-81.
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