Vol. 5, Issue 2, Part A (2023)

Genetic variants of transcription factor7, such as the TCF7L2 gene, have been found to be highly linked diabetes to type 2. Familial combined hyperlipidaemia (FCHL) is defined by hypercholesterolemia, hypertriglyceridemia, or together. Furthermore, abnormalities of glucose metabolism are frequent in FCHL. As a result, the present study suggested hypothesized that TCF7L2 could be linked to the genetic predisposition for this frequent dyslipidemia in a very female populace of Iraq. As a result, we proposed that TCF7L2 could be linked to the hereditary predisposition to this frequent dyslipidemia in a predominantly female Iraqi population. The current investigation included 50 DM2 with FCHL female patients and 50 samples that were healthy. A single primer for amplification was used for analyzing the gene, and the PCR approach was combined with sequencing. This study looked at the effect of TCF7L2 polymorphism on FCHL and the component characteristics lipid profile and kidney function test in serum by using chemical testing equipment. The findings: For total subjects, (G/A vs. AG + GT) were substantially higher in FHCL cases than in control groups, and TCh,TG, ApoB, or hyperglycemia were linked with G>A and G>T genotypes of the TCF7L2 in Iraqi females which increased the risk of FHCL. In the TCF7L2 gene the allele G was more common in FHCL cases than in controls subjects. Conclusions: Our findings suggested that TCF7L2 genetic variants were substantially correlated to increased G>A and G>T in FCHL together with DM2 in Iraqi females.