Bisphosphonates from a medical perspective: survey through questionnaire

Authors

DOI:

https://doi.org/10.33448/rsd-v12i7.42601

Keywords:

Bisphosphonates; Osteonecrosis; Physicians; Dentists.

Abstract

There is some controversy about the safety of invasive dental treatments in patients on bisphosphonates. The objective of this research was to verify, through the application of a questionnaire, the degree of knowledge that specialist physicians in Geriatrics, Rheumatology, Orthopedics, Gynecology and Oncology have about the interrelationship between the use of bisphosphonates and their effect on the bones of the maxilla and mandible. 100 health professionals were selected, uniformly distributed in five specialties. All were submitted to a questionnaire and the answers were tabulated. The highest indication of bisphosphonates was for osteoporosis 94%, followed by bone metastasis, Paget's disease, hypercalcemia, lytic lesion and bone fracture. As for the class of bisphosphonates, 50% of gynecologists, 78% of orthopedists, 94% of geriatricians and 100% of oncologists and rheumatologists answered that they prescribe the nitrogen class. Regarding the route of administration, geriatricians, gynecologists, orthopedists and rheumatologists prefer the oral route and only oncologists reported a preference for the parenteral route. The risk of osteonecrosis of the jaw related to the use of bisphosphonates is accepted by most physicians interviewed. All respondents refer all patients who have complications in the oral cavity resulting from the use of bisphosphonates to the dentist, however, they still do not indicate regular visits to the dentist before the onset of complications. We consider that there should be greater communication between the doctor and the dentist in cases where the patient uses bisphosphonates before and during treatment to minimize the severity of injuries involving the maxilla and mandible bones.

References

Aghaloo, T., Hazboun, R. & Tetradis, S. Pathophysiology of Osteonecrosis of the Jaws. (2015). Oral Maxillofac Surg Clin North Am. 27(4): 489-496. 10.1016/j.coms.2015.06.001

Agrillo A., Filiaci, F., Ramieri, V., Riccardi, E., Quarato, D., Rinna, C., Gennaro, P., Cascino, F. & Ungari, C. (2012). Bisphosphonate - related osteonecrosis of the jaw (BRONJ): 5-year experience in the treatment of 131 cases with ozone therapy. Eur Rev Med P harmacol Sci. 16(12): 1741-7.

Alonso-Rodriguez, E., González-Martín-Moro, J., Cebrián-Carretero, J. L., Del Castillo, J. L., Pozo-Kreilinger, J. J., Ruiz-Bravo, E., García-Arranz, M., Hernández-Godoy, J. & Burgueño, M. (2019). Bisphosphonate-related osteonecrosis. Application of adipose-derived stem cells in an experimental murine model. Med Oral Patol Oral Cir Bucal. 24 (4): e529-36.

Dell, M., Adams, L., Greene, F., Funahashi, T., Silverman, L., Eisemon, O., Zhou, H., Burchette, J. & Ott, M. (2012). Incidence of atypical nontraumatic diaphyseal fractures of the femur. Journal of Bone and Mineral Research. 27(12): 2544- 50.

Dimopoulos A., Kastritis, E., Bamia, C., Melakopoulos, I., Gika, D., Roussou, M., Migkou, M., Papaiakovou, E., Christoulas, D., Terpos, E.& Bamias, A. (2009). Reduction of osteonecrosis of the jaw (ONJ) after implementation of preventive measures in patients with multiple myeloma treated with zoledronic acid. Annals of Oncology. 20(1): 117 -20.

Dodson, T. (2009). Intravenous Bisphosphonate Therapy and Bisphosphonate- Related Osteonecrosis of the Jaws. Journal of Oral and Maxillofacial Surgery. 67(5): 44-52.

Erviti, J., Alons,o Á., Oliva B., Gorricho, J., López, A., Timoner,, J., Huerta C., Gil, M. & Abajo, F. (2013). Oral bisphosphonates are associated with increased risk of subtrochanteric and diaphyseal fractures in elderly women: a nested case- control study. BMJ Open. 20; 3(1).

Feldstein, A., Black, D., Perrin, N., Rosales, G., Friess, D., Boardman, D., Dell, R., Santora, A., Chandler, J., Rix, M. & Orwoll, E. (2012). Incidence and demography of femur fractures with and without atypical features. Journal of Bone and Mineral Research. 27(5): 977-86.

Fung, P., Nicoletti, P., Shen, Y. & Porter, S. (2015). Pharmacogenetics of Bisphosphonate-associated Osteonecrosis of the Jaw. Oral Maxillofac Surg Clin North Am. 27:537–46.

Ghoneima, A., Allam, S., Zunt L. & Windsor, J. (2010). Bisphosphonates treatment and orthodontic considerations. Orthodontics e Craniofacial Research. 13(1): 1-10.

Goss, A., Bartold, M., Sambrook, P. & Hawker, P. (2010). The nature and frequency of bisphosphonates-associated osteonecrosis of the jaws in dental implant patients: a south Australian case series. Journal of Oral and Maxillofacial Surgery. 68(2): 337-43.

Holzinger, D., Seemann, R., Matoni, N., Ewers, R., Millesi, W. & Wutzl, A. (2014). Effect of dental implants on bisphosphonate-related osteonecrosis of the jaws. J Oral Maxillofac Surg. 72:1937. e1-8.

Lazarovici, T., Yahalom, R., Taicher, S., Elad, S., Hardan, I. & Yarom, N. (2009). Bisphosphonate-related osteonecrosis of the jaws: a single-center study of 101 patients. Journal of Oral and Maxillofacial Surgery. 67(4): 850-5.

Leung, F., Rabie, A. & Wong, R. (2009). Osteoporosis, Osteonecrosis, and Orthodontics. World Journal of Orthodontic. 10(3):261-71.

McClung, M., Harris, T., Miller D., Bauer, C., Davison, S., Dian L., Hanley, D., Kendler, D., Yuen, C. & Lewiecki, M. (2013). Bisphosphonate Therapy for Osteoporosis: Benefits, Risks, and Drug Holiday. The American journal of medicine. 126(1): 13-20.

Meier, R., Perneger, T., Stern, R., Rizzoli, R. & Peter, R. (2012). Increasing occurrence of atypical femoral fractures associated with bisphosphonate use. Archives of Internal Medicine. 172(12): 930-6.

Papapetrou, P. (2009). Bisphosphonate-associated adverse events. Hormones (Athens). 8(2): 96-110.

Ribeiro de-Freitas, N., Lima L., Boaventura de-Moura, M., César Simamoto-Jr, P. & de Magalhães, D. (2016). Bisphosphonate treatment and dental implants: A systematic review. Med Oral Patol Oral Cir Bucal. 21:e644–e51.

Ruggiero, S., Dodson, B., Assael, A., Landesberg, R., Marx, E. & Mehrotra, B. (2009). American Association of Oral and Maxillofacial Surgeons position paper on bisphosphonate-related osteonecrosis of the jaw. Journal of Oral and Maxillofacial Surgery. 67(5), 2-12.

Ruggiero, S. L., Dodson, T. B., Fantasia, J., Goodday, R., Aghaloo, T., Mehrotra, B., et al. (2014). American association of oral and maxillofacial surgeons position paper on medication-related osteonecrosis of the jaw - 2014 update. J Oral Maxillofac Surg. American Association of Oral and Maxillofacial Surgeons. 72:1938-56.

Russel, R. (2011). Bisphosphonates: The first 40 years. Bone. 49(1): 2- 19.

Sebestyen, J., Srivastava, T. & Alon, U. (2012). Bisphosphonates use in children. Clinical Pediatrics. 51(11): 1011-24.

Severino, A. J. (2013). Metodologia do trabalho científico. Cortez Editora.

Shane, E., Burr, D., Ebeling, P., Abrahamsen, B., Adler, R., Brown, T., Cheung, A., Cosman, F., Curtis, E., Dell, R., Dempster, D., Einhorn, T., Genant, H., Geusens, H., Klaushofer, K., Koval, K., Lane, J., McKiernan, F., McKinney, R., Ng, A., Nieves, J., O´Keefe, R., Papapoulos, S., Sen H., Meulen, M., Weinstein, R. & Whyte, M. (2010). Atypical subtrochanteric and diaphyseal femoral fractures: report of a task force of the American Society for Bone and Mineral Research. Journal of Bone and Mineral Research. 25(11): 2267-94.

Shin, E., Kwon, Y., Herr, Y., Shin, S. & Chung, J. (2010). Implant failure associated with oral bisphosphonate-related osteonecrosis of the jaw. Journal of periodontal & implant science. 40(2): 90-5.

Silva, L. F., Curra, C., Munerato, M. S., Deantoni, C. C., Matsumoto, M. A., Cardoso, C. L., et al. (2016). Surgical management of bisphosphonate-related osteonecrosis of the jaws: literature review. Oral Maxillofac Surg Clin North Am. 20:9–17.

Vescovi, P., Campisi, G., Fusco, V., Mergoni, G., Manfredi, M., Merigo, E., Solazzo, L., Gabriele, M., Gaetaf, G., Favia, G., Peluso, F. & Colella, G. (2011). Surgery-triggered and non-surgery-triggered Bisphosphonate-related Osteonecrosis of the Jaws (BRONJ): a retrospective analysis of 567 casein an Italian multicenter study. Oral oncology. 47(3):191-94.

Vestergaard, P., Schwartz, K., Rejnmark L., Mosekilde L. & Pinholt E. (2012). Oral bisphosphonate use increases the risk for inflammatory jaw disease: a cohort study. Journal of Oral and Maxillofacial Surgery. 70(4): 821-9.

Yip, K., Borrell, N., Cho, C., Francisco, H. & Tarnow, P. (2012). Association between oral bisphosphonate use and dental implant failure among middle-aged women. Journal of clinical periodontology. 39(4): 408-14.

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Published

23/07/2023

How to Cite

QUEIROZ, R. G. L. de; CASTRO-MERÁN, A. P. .; FERREIRA JÚNIOR, O. .; CARVALHO, P. P. de . Bisphosphonates from a medical perspective: survey through questionnaire. Research, Society and Development, [S. l.], v. 12, n. 7, p. e12412742601, 2023. DOI: 10.33448/rsd-v12i7.42601. Disponível em: https://rsdjournal.org/index.php/rsd/article/view/42601. Acesso em: 27 apr. 2024.

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Health Sciences