Evaluation of In vitro Antimicrobial and In vivo Cytotoxic Properties of Peroxo Coordination Complexes of Mg(II), Mn(II), Fe(II) & Ni(II)

Abstract

Six newly synthesized nickel peroxo coordination complexes, [Mg2(2-ap)2(O2)(OH), A], [Mn(2-ap) (ED)(O2), B], [Fe(2-ab)(ED)(O2), C], [Fe(2-ap)(ED)(O2), D], [Ni2(2-ab)2(O2)(OH), E] and [Ni2(2-ap)2(O2)(OH), F] showed significant antibacterial and antifungal activities. The minimum inhibitory concentrations (MIC) of these compounds were found in the range of 8-128 µg/ml. Among these compounds, F showed maximum cytotoxicity (LC50 = 3.62 µg/ml) in brine shrimp lethality bioassay. Key words: Peroxo coordination complexes; Antimicrobial activity; antifungal activity; cytotoxic activity. Dhaka Univ. J. Pharm. Sci. Vol.3(1-2) 2004 The full text is of this article is available at the Dhaka Univ. J. Pharm. Sci. website