Assessment of Thyroid Peroxidase Antibody And Thyroid Stimulating Hormone In First Trimester Of Pregnancy

Authors

  • Nishat Un Nahar Sadar Lalmonirhat, Rangpur
  • Zeba Un Naher Department of Biochemistry, BSMMU, Dhaka
  • Md. Ashanul Habib Rangpur Medical College Hospital, Rangpur
  • Forhadul Hoque Mollah Department of Biochemistry, BSMMU, Dhaka

DOI:

https://doi.org/10.3329/bjms.v12i2.14945

Keywords:

Thyroid Peroxidase Antibody, Thyroid Status, Pregnancy

Abstract

Introduction: Maternal thyroid dysfunction during pregnancy has been associated with a number of adverse outcomes, like preterm birth, placental abruption, foetal death and impaired neurological development in the child. Simultaneously the presence of antibody to thyroid peroxidase results miscarriage, preterm birth and maternal post partum thyroid disease. Post partum thyroiditis is closely associated with the presence of antibodies to thyroid peroxidase (TPO). Indeed if a pregnant woman is positive for TPO antibodies early in pregnancy, her chances of developing post partum thyroiditis is 30-52%.

Objective: To find out the level of TPO-Ab and thyroid status in first trimester of pregnancy.

Method: The cross sectional study was designed in Department of Biochemistry, BSMMU, Dhaka. Following inclusion and exclusion criteria 200 sample was selected by purposive and convenient sampling. The study parameters were- thyroid peroxidase antibody (TPO-Ab); serum thyroid stimulating hormone (TSH); serum free thyroxin (FT4).

Results: 43 (21.5%) pregnant women of first trimester was found to be TPO-Ab positive, among these 43 subjects 16 (8.0%) had raised TSH i.e. >2.5 mIU/L and 27 had TSH level <2.5 mIU/L. Low serum FT4 was in 9 (4.5%) subjects. The study revealed that, there was a significant positive correlation between positive TPO-Ab (>12 IU/mL) and serum TSH level of study subjects and there was negative correlation between serum TSH (>2.5 mIU/L) and serum FT4 in study subjects.

Conclusion: TPO-Ab positivity in first trimester of pregnancy and TPOAb positivity was associated with higher TSH and low FT4 level.

Bangladesh Journal of Medical Science Vol. 12 No. 02 April13 Page 164-170

DOI: http://dx.doi.org/10.3329/bjms.v12i2.14945

Downloads

Download data is not yet available.
Abstract
1147
PDF
1419

Downloads

Published

2013-05-13

How to Cite

Nahar, N. U., Naher, Z. U., Habib, M. A., & Mollah, F. H. (2013). Assessment of Thyroid Peroxidase Antibody And Thyroid Stimulating Hormone In First Trimester Of Pregnancy. Bangladesh Journal of Medical Science, 12(2), 164–171. https://doi.org/10.3329/bjms.v12i2.14945

Issue

Vol. 12 No. 2 (2013)

Section

Original Articles

License

Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that:

  1. Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work.

  2. Creative Commons Licence
    Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.
  3. Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
  4. Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.