Scientiae Mathematicae Japonicae
Online ISSN : 1346-0447
MATHEMATICAL AND COMPUTER MODELLING REGULATORY MECHANISMS FOR PROGRAMMED CELL DEATH (APOPTOSIS)
Mohiniso Bahromovna Hidirova
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2008 Volume 67 Issue 2 Pages 279-289

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Abstract

The system for removing needless cells (programmed cell death - apopto- sis) is important in coordination of structural-functional organisation of large number of cells in an organism. Discovery of cells suicide phenomenon has allowed revising old notions about regulation mechanisms of cellular homeostasis and importance of this mechanisms disturbance during development of large number of diseases including cancer, auto-immune diseases and infection processes. Intuitive understanding activ- ity of the regulatory system connected by means of complex interaction mechanisms between positive and negative feedback loops is very difficult. Here it is necessary for- mal mathematical methods and computer tools for modelling corresponding regulatory mechanisms. This work deals with some results of the quantitative analysis of simplest regulatory mechanisms for apoptosis process based on the methods for mathematical modeling and computer simulation.

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© 2008 International Society for Mathematical Sciences
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