Synthesis of new imidazolidin-2-ones based on the reaction of 1-(2,2-dimethoxyethyl)urea with C-nucleophiles
- Authors: Smolobochkin A.V1, Kuznetsova E.A1, Gazizov A.S1, Burilov A.R1, Pudovik M.A1
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Affiliations:
- Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”
- Issue: Vol 93, No 6 (2023)
- Pages: 835-839
- Section: Articles
- URL: https://journals.rcsi.science/0044-460X/article/view/145059
- DOI: https://doi.org/10.31857/S0044460X23060021
- EDN: https://elibrary.ru/FJUKMS
- ID: 145059
Cite item
Abstract
The acid-catalyzed reaction of 1-(2,2-dimethoxyethyl)ureas with aromatic and heterocyclic nucleophiles leads to the formation of new imidazolidin-2-ones. The proposed method makes it quite easy to introduce the required pharmacophore group into position 4 of the imidazolidine cycle.
Keywords
About the authors
A. V Smolobochkin
Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”
Email: smolobochkin@iopc.ru
E. A Kuznetsova
Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”
A. S Gazizov
Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”
A. R Burilov
Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”
M. A Pudovik
Arbuzov Institute of Organic and Physical Chemistry, Federal Research Center “Kazan Scientific Center of the Russian Academy of Sciences”
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