In recent years our ability to study, visualize and engineer processes on the nano-scale has grown tremendously. This has led to great advances in our understanding of processes on the nano-scale, and has raised interesting possibilities for future technological development. This is particularly the case for nano-fluidics, with potential for the engineering of systems such as highly-efficient membranes and self-cleaning surfaces. Due to the small scales involved, experiment is highly challenging, and so simulation has come to play an important complementary role in our exploration of the nano-scale. In this article we therefore provide an insight into the properties of nano-scale flow, and how we might control it through our emerging ability for precision-engineered nano-scale structures. Furthermore, we give an overview regarding simulation of non-equilibrium flow on the nano-scale, and draw attention to emerging computational methods and remaining challenges.