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Licensed Unlicensed Requires Authentication Published by De Gruyter May 23, 2013

The effects of metal implants on inflammatory and healing processes

  • Roman Tsaryk , Kirsten Peters , Ronald E. Unger , Dieter Scharnweber and C. James Kirkpatrick

Abstract

Metal implants are known for their superior mechanical properties. However, cases of implant failure mainly due to aseptic loosening do occur. The formation of particulate wear debris and corrosion products, such as metal ions and reactive oxygen species, are considered to be crucial factors leading to the failure of metal implants. These metal degradation and corrosion products can induce inflammatory responses, mediated among others by neutrophils, macrophages and endothelial cells. Furthermore, these degradation products may affect blood vessel formation, one of the central processes in wound healing after implantation. Such events can lead to the aseptic loosening of implants culminating in the necessity for revision surgery.


* Correspondence address, Prof. Dr. C. James Kirkpatrick, Institute of Pathology, Johannes Gutenberg-University Mainz, Langenbeckstr. 1, D-55101 Mainz, Germany, Tel.: +49 6131 177301, Fax: +49 6131 1747 7301, E-mail:

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Received: 2007-2-5
Accepted: 2007-4-21
Published Online: 2013-05-23
Published in Print: 2007-07-01

© 2007, Carl Hanser Verlag, München

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