- Academic Editor
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Background: The aim of this study was to determine whether
dexmedetomidine can reduce the circulatory response in laparoscopic uterine
fibroids (UF) surgery. Our purpose was to investigate the effect of
dexmedetomidine on the circulatory response in laparoscopic UF surgery.
Methods: This was a randomized controlled study of 214 patients age
range of 40–60 years, American Society of Anesthesiologists (ASA) 1–2 grade,
undergoing elective laparoscopic UF surgery at Fuxing Hospital, Capital Medical
University from January 2020 to October 2023. Patients were randomly allocated to
the non-dexmedetomidine group (Group1) and dexmedetomidine group (Group2). The
mean arterial pressure (MAP) and heart rate (HR) were measured: when entering the
operation room (MAP1, HR1), immediately at the time of local pituitrin injection
(MAP2, HR2), and at 5 minutes after injection of pituitrin (MAP3, HR3). The
medications and dosages (propofol, urapidil hydrochloride, fluid) used during the
operation were recorded as well as the recovery (drowsiness, chills, nausea,
vomiting, dysphoria) after the operation. Total mean time from the beginning of
the operation to pituitrin injection (Time1) and recovery time after peaking
blood pressure with pituitrin injection (Time2) were also recorded.
Results: There were no significant differences in age, height, weight,
size and number of UFs, and the location of uterine fibroids between the two
groups. There were no differences between the groups for MAP1, MAP2, HR1, HR2,
HR3, and Time1 (all p