Academic Editor: Qian Zhong
Background: Endometriosis is one of the common benign
gynecological diseases among reproductive aged women, which almost lead to pelvic
pain, infertility and menstrual disorders. There is no blood test available for
the diagnosis of endometriosis. MUC17 has been revealed to play a role
in a variety of cancers, but the role of MUC17 single nucleotide
polymorphisms (SNPs) in endometriosis susceptibility remains unclear.
Methods: In the present study, genotyping for four MUC17
polymorphisms in 117 endometriosis patients and 118 female
control participants was undertaken using the Agena Mass ARRAY. An unconditional
logistic regression model was used to estimate the role of MUC17 gene
polymorphisms in endometriosis. Results: Bioinformatics analysis showed
that rs6966570 could be relevant to the transcription factor binding sites of
proteins bound and was related to expression quantitative trait Loci (eQTL) and
Motifs. Rs10246021 affected eQTL and Motifs. Nevertheless, there was no
significant difference in the frequency of mutation of MUC17 gene
between the case group and the control group (p