Hypothyroidism and myasthenia gravis: A rare association
Department of Endocrinology Diabetology and Metabolic Diseases, PCIM Laboratory, FMPM, Cadi Ayyad University, CHU Mohamed VI Marrakech, Morocco.
Case Study
World Journal of Advanced Research and Reviews, 2023, 17(02), 739–741
Publication history:
Received on 08 January 2023; revised on 19 February 2023; accepted on 22 February 2023
Abstract:
The prevalence of endocrinopathies during myasthenia is relatively common. The association of myasthenia with dysthyroidism can make the diagnosis of these two conditions difficult, because of the similaritý of some clinical signs. Several disorders of specifically thyroid immunologic origin have beeń reported in myasthenic patients. This relationship remains poorly elucidated, but an immunologic cross-reaction between the neuromuscular junction and thyroid components has been found in myasthenia and Graves' disease. It is generally accepted that the association between hyperthyroidism and myasthenia is much more frequent than that between myasthenia and hypothyroidism. However, no clear explanation has been proposed for this difference. We report the case of a 28-year-old patient who was initially followed for myasthenia under anticholinesterase therapy and whose evolution was marked by the discovery of hypothyroidism during follow-up. The patient responded well to replacement therapy with a good evolution.
Keywords:
Hypothyroidism; Myasthenia; Dysthyroidism; Autoimmunity
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Copyright © 2023 Author(s) retain the copyright of this article. This article is published under the terms of the Creative Commons Attribution Liscense 4.0