The research of the generalized tonic-clonic seizure epilepsy by resting state Fmri

DOI

10.2991/icismme-15.2015.346How to use a DOI?

Keywords

epilepsy; fMRI; Pearson correlation; network attributes; synchronicity

Abstract

In this study, we investigated the human brain functional network of patients with generalized tonic and clonic seizure (GTCS) epilepsy by using the resting-state functional magnetic resonance imaging (fMRI) and complex network theory. Adjacency matrices of the networks of GTCS group and normal control group were constructed by the method of Pearson correlation coefficient. A intra-group analysis was performed to get a statistical map of each group. And it was contrasted the attributes of brain network from two aspects of the "small world" property and network efficiency. Furthermore, a inter-group analysis was conducted to investigate differences between GTCS group and normal control group. Our results showed the "small world" property and network efficiency of GTCS group were decreased compared to the controls. In addition, the patients exhibited increased correlation coefficient mainly concentrated in the thalamus and the lentiform nucleus, while the decreased correlation coefficient was mainly distributed in the precuneus and frontal lobe, the inferior frontal gyrus, the inferior parietal gyrus, the superior parietal gyrus. The result indicated that information transmission ability of brain function network in patients with GTCS is impaired. And it also suggested that the method of Pearson correlation coefficient can detect synchronization change of blood-oxygen levels in the brain so that achieved the goal of positioning detection of epileptic activity.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Ming Ke
AU  - Xiaoxin Duan
AU  - Fan Zhang
AU  - Xiaoping Yang
PY  - 2015/07
DA  - 2015/07
TI  - The research of the generalized tonic-clonic seizure epilepsy by resting state Fmri
BT  - Proceedings of the First International Conference on Information Sciences, Machinery, Materials and Energy
PB  - Atlantis Press
SP  - 1672
EP  - 1677
SN  - 1951-6851
UR  - https://doi.org/10.2991/icismme-15.2015.346
DO  - 10.2991/icismme-15.2015.346
ID  - Ke2015/07
ER  -