Pyroptosis, PANoptosis and ferroptosis in cardiac ischaemia/reperfusion injury

█ Review

DOI: 10.26430/CHUNGARICA.2023.53.5.451

Authors:
Pipicz Márton^*, Demján Virág^*, Csonka Csaba, Csont Tamás
Szegedi Tudományegyetem, Szent-Györgyi Albert Orvostudományi Kar,
Biokémiai Intézet, Metabolikus Betegségek és Jelátvitel (MEDICS) Kutatócsoport, Szeged
Szegedi Tudományegyetem, Interdiszciplináris Kutatásfejlesztési és Innovációs Kiválósági Központ, Szeged

Summary

Despite intensive research, we still do not have cardioprotective drugs that can effectively reduce infarct size associated with ischaemia/reperfusion (I/R) injury of the heart. One of the underlying explanations behind this is that the complex process of cell death in I/R is not yet fully understood. A more detailed understanding of the mechanism may improve the translational feasibility of cardioprotective drug development. In addition to the well-known regulated (apoptosis, autophagy-mediated cell death) and non-regulated (necrosis) cell death, novel programmed cell death types and mechanisms have been elucidated in recent years, such as pyroptosis, PANoptosis or ferroptosis. In the present review, we will briefly describe these processes in cardiac I/R injury and we discuss the potential modulation strategies.

ISSUE: CARDIOLOGIA HUNGARICA | 2023 | VOLUME 53, ISSUE 5

click here to read the full article		click here to read the pdf
Watch the video summary

---