Antifungal Activities of Ethyl Acetate and Methanol Extracts of Annona Muricata Aerial Part

Abstract

The medicinal plants are the plants people use with the intention of maintaining good health and as they are known to contain bioactive compounds that have therapeutic properties. The antifungal activities of Annona muricataaerial part extracts against Candida albicaus, Pencillium notatum, Aspergillus niger, Rhizophus stoloniferwere investigated. The medicinal plants were dried andextracted sequentially using hexane, ethyl acetate and methanol respectively. The ethyl acetate extract of Annona muricataaerial part at 100mg/ml concentrationexhibited the highest value of zone of inhibition of 19.0±1.00mm against Candida albicaus, Aspergillus niger and Rhizophus stolonizerrespectively, while the methanol extracthighest zone of inhibition at 100mg/ml concentration was 15.0±1.00mm against Candida albicans. Ethyl acetate extract of Annona muricataaerial part exhibited zone of inhibition in all the concentrations while its methanol extract did not exhibit zone of in hibitionat 12.5mg/ml, 6.25mg/ml and 3.125mg/ml concentrations. Ethyl acetate had the minimum inhibitory concentration (MIC) of 1.25mg/ml against all the test organisms. In this research work the ethyl acetate extract of Annona muricataaerial part proved to have a better antifungal property against Aspergillus niger, Pencillium notatum and Rhizophus stolonizer.