The Necessity of Radicals for Gene Transfection by Discharge Plasma Irradiation

Masafumi Jinno; Yoshihisa Ikeda; Hideki Motomura; Yugo Kido; Kunihide Tachibana; Susumu Satoh

doi:10.2494/photopolymer.27.399

Masafumi Jinno, Yoshihisa Ikeda, Hideki Motomura, Yugo Kido, Kunihide Tachibana, Susumu Satoh

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Keywords: gene transfection, atmospheric plasma, micro plasma, radical, plasma gene transfection

JOURNAL FREE ACCESS

2014 Volume 27 Issue 3 Pages 399-404

DOI https://doi.org/10.2494/photopolymer.27.399

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Abstract

The authors parametrically investigated gene transfer process with a micro capillary discharge. Several factors and the time scale at which they become effective were studied. The conclusion is that half of transfections occur during plasma irradiation and the other half occur after plasma irradiation is stopped. As the electric field and current become zero after plasma irradiation is terminated, we conclude that during that period radical species are necessary for the transfection.

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