Callosal and Diffuse White Matter Lesions with Restricted Water Diffusion in Hemophagocytic Syndrome

Reiichi ISHIKURA; Kumiko ANDO; Shozo HIROTA; Noriaki OKAMOTO; Girish FATTERPEKAR; Michael SACHER

doi:10.2463/mrms.9.91

Clinical Image

Callosal and Diffuse White Matter Lesions with Restricted Water Diffusion in Hemophagocytic Syndrome

Reiichi ISHIKURA, Kumiko ANDO, Shozo HIROTA, Noriaki OKAMOTO, Girish FATTERPEKAR, Michael SACHER

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Keywords: corpus callosum, diffusion-weighted image, hemophagocytotic syndrome, MRI

JOURNAL OPEN ACCESS

2010 Volume 9 Issue 2 Pages 91-94

DOI https://doi.org/10.2463/mrms.9.91

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Abstract

We present magnetic resonance (MR) imaging findings of the brain of a 6-year-old girl with fatal hemophagocytic syndrome (HPS); diffusion-weighted imaging shows abnormal intensity in the white matter and entire corpus callosum. HPS is a rare disorder that affects the mononuclear phagocyte system and not uncommonly involves the central nervous system. Various MR imaging findings of HPS have been reported, but restricted water diffusion throughout the entire corpus callosum lesion and lesions of the white matter have not been reported.

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