Macrocyclic secopyrrolizidine, senkirkine(1) was isolated from Farfugium japonicum. The new cytotoxic alkaloids, syneilesine and acetylsyneilesine were isolated from Syneilesis palmata and determined as formulae 2 and 3 by chemical and spectral evidences. The new carcinogenic alkaloid, fukinotoxin isolated from young scape of Petasites japonicus was determined as formula 5 by chemical evidence and X-ray crystallographic analysis.