A mobile nursing app (mNurse) have demonstrated a significant time saving (TS) in compare with the traditional Nursing Information System (NIS). Decision tree is a prediction model using tree structure or hierarchical structure. We build a decision tree model to illustrate the willingness of job retention in 120 nurse’s dataset. We applied the C4.5 algorithm by using Weka machine learning analysis freeware. A nurse will make a decision of Job retention if the TS>70 seconds. In the group of TS ≤70 seconds, a nurse with age less than or equal to 26 years old won’t make a decision of Job retention. Finally, in the group of nurses with age greater than 26 years old, a nurse with working year (WY) of 8 or less will make the decision of job retention whereas WY greater than 8 won’t.