Diabetes mellitus, hypertension, hyperlipidemia, and hyperuricemia are called lifestyle related disease. Gene Expression programming might be one of the best programming methods to reconstruct disease tissue histology. The arteriosclerosis represents the terminal state of vascular degeneration depending on long never-ending diabetes, hypertension, and hyperlipidemia. Histological reconstruction might induce the better disease situation. We created 5 basic commands to control vascular atherosclerosis. One: β-oxidation, 2: Activate PPP, and 3: Inhibition of collagen synthesis, those are introduced from Biochemical Expression Programming (BEP). Four: digest collagen is introduced from Gene expression Programming (GEP). Five: Suspend embolism is an example of medicine-expression programming (MEP). We succeeded to decrease the hypotensives by GEP programmed to clean up atherosclerotic blood vessels.