ORIGINAL ARTICLE   

Minerva Pediatrics 2023 August;75(4):501-5

DOI: 10.23736/S2724-5276.18.05313-6

Copyright © 2018 EDIZIONI MINERVA MEDICA

language: English

A study on the effect of joint detection of biochemical markers and electrophysiological examination in the early diagnosis of children with Green-Barre Syndrome

Kaili XU, Guohong CHEN ✉, Yanli MA, Yuan WANG

Department of Neurology, Children’s Hospital Affiliated to Zhengzhou University, Henan Children’s Hospital, Zhengzhou Children’s Hospital, Zhengzhou, China

BACKGROUND: The aim of this study was to investigate the effect of early diagnosis in children with Green-Barre Syndrome (GBS) via joint detection of biochemical markers and electrophysiological examination.
METHODS: A total of 90 children with (GBS collected from the Department of Neurology, Intensive Care Unit (ICU), Rehabilitation Department of Cerebral Palsy of Children’s Hospital Affiliated to Zhengzhou University, Department of Pediatrics of First Affiliated Hospital of Zhengzhou University and Henan Province People’s Hospital were selected as the research objects. According to their onset time, they were divided into group A (N.=30) hospitalized within 3 days of onset, group B (N.=30) hospitalized from 4 to 7 days of onset, and group C (N.=30) hospitalized after more than 7 days of onset. The titer levels of serum anti-ganglioside immunoglobulin G (IgG) antibodies, the motor nerve conduction velocity (MCV), Hoffmann reflex (H-reflex) condition and serum immunoglobulin in all groups of children were compared.
RESULTS: The levels of serum anti-ganglioside IgG antibodies in three groups of children from low to high were group ACONCLUSIONS: Anti-ganglioside antibody, electrophysiological parameter and serum level of immunoglobulin can be helpful in the diagnosis of GBS, and the changes in them can be monitored clinically so as to carry out the early treatment effectively for children and improve the prognosis.

KEY WORDS: Antibodies; Immunoglobulins; Diagnosis