Original Article   

The Quarterly Journal of Nuclear Medicine and Molecular Imaging 2022 Oct 26

DOI: 10.23736/S1824-4785.22.03483-5

Copyright © 2022 EDIZIONI MINERVA MEDICA

language: English

Comparison of single photon emission computed tomography-computed tomography, computed tomography and magnetic resonance imaging of osteonecrosis of jaw by new calculated parameters

Yoshiyuki MINAMI ¹ ✉, Ichiro OGURA ^{1, 2}

¹ Quantitative Diagnostic Imaging, Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics, Course of Applied Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata, Niigata, Japan; ² Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Life Dentistry at Niigata, Niigata, Japan

BACKGROUND: This study aimed to investigate parameters for medication-related osteonecrosis of jaw (MRONJ) patients using the bone SPECT/CT, especially bone mineral-based parameters.
METHODS: Sixty-three patients with MRONJ (43 osteoporosis and 20 bone metastasises) underwent CT, MRI and SPECT/CT. A commercially available software automatically detected lesion area and calculated the quantitative SPECT/CT parameters as bone mineral-based standardized uptake value (SUV).
RESULTS: Regarding stage of MRONJ patients, bone mineral based maximum SUV of stage 3 was significantly higher than stage 1, 2 (P = 0.018). Regarding duration of medication therapy, bone mineral based maximum SUV 1 year or more was significantly higher than less than 1 year P = 0.019). Regarding present of periosteal bone proliferation on CT, bone mineral based maximum SUV was significantly higher than those of absent (P = 0.029). Regarding spread of soft tissue inflammation on MRI, bone mineral based maximum SUV of 2 or more was significantly higher than those of less than 2 spaces (P = 0.025). Regarding blood pool phase imaging with SPECT, bone mineral based maximum SUV of intense uptake was significantly higher than those of decrease uptake (P = 0.002).
CONCLUSIONS: SPECT/CT bone mineral-based parameters indicated significant difference in staging, dosing period, periosteal bone proliferation on CT, spread of soft tissue inflammation on MRI, and blood phase imaging with SPECT. Bone SPECT/CT bone mineral-based parameters are helpful for the assessment of MRONJ.

KEY WORDS: Bisphosphonate-associated osteonecrosis of the jaw; Symptom assessment; Single photon emission computed tomography computed tomography