ORIGINAL ARTICLE  VENOUS DISEASE 

International Angiology 2024 April;43(2):240-6

DOI: 10.23736/S0392-9590.24.05142-3

Copyright © 2024 EDIZIONI MINERVA MEDICA

language: English

The characteristics of arterial risk factors and ankle-brachial index in patients with lower extremity chronic venous diseases: results from the BEST study

Shangtong JIANG ^{1, 2, 3, 4}, Yue LIU ^{1, 2, 3}, Jinbo LIU ^{1, 2, 3, 5}, Gaoqiang XIE ^{3, 5}, Hongwei ZHAO ^{1, 2, 3, 5}, Na ZHAO ^{1, 2, 3, 5}, Hongyu WANG ^{1, 2, 3, 4, 5, 6, 7} ✉

¹ Vascular Medicine Center, Shougang Hospital, Peking University, Beijing, China; ² Beijing Shijingshan District Key Clinical Specialty of Vascular Medicine, Beijing, China; ³ Vascular Health Research Center of Peking University Health Science Center (VHRC-PKUHSC), Beijing, China; ⁴ State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing, China; ⁵ Heart and Vascular Health Research Center of Peking University Clinical Research Institute (HVHRC-PUCRI), Beijing, China; ⁶ Heart and Vascular Health Research Center of Chengdu Medical College (HVHRC-CMC), Chengdu, China; ⁷ Intelligent Heart and Vascular Health Digital Management Research Center, Health Big Data National Research Institute, Peking University, Beijing, China

BACKGROUND: The aim of our study was to explore the characteristics of the arterial risk factors and ankle-brachial index (ABI) in patients with lower extremity chronic venous disease (LECVD).
METHODS: A total of 2642 subjects were employed in our study. The lifestyle and clinical data were collected. The history of vascular diseases contained coronary artery disease, stroke, hypertension, and diabetes. ABI low than 0.9 was considered as lower extremity artery disease (LEAD). A series of blood indicators were measured.
RESULTS: Patients with ABI low than 0.9 belonged to the group of LEAD. Age, smoking, drinking, hypertension, diabetes mellitus, lipid-lowering drug, antidiabetic, total protein, total protein, triglyceride, low-density lipoprotein cholesterol, glycosylated hemoglobin and homocysteine were the common risk factors shared by LEAD and LECVD (P<0.05). The prevalence of LEAD in patients with LECVD was higher than those without LECVD (P<0.05). In Pearson correlation analysis, LECVD was related to LEAD (P<0.05). Before and after adjusted shared factors, as the performance of the logistic regression models, LEAD was an independent risk factor for the prevalence of LECVD (OR=2.937, 95% CI: [1.956, 4.411], P<0.001).
CONCLUSIONS: Our study demonstrated that an ABI lower than 0.9 is an independent risk factor for LECVD.

KEY WORDS: Lower extremity; Arteries; Risk factors; Ankle Brachial Index