Dataset for: Repeated low doses of LSD in healthy adults: A placebo-controlled, dose-response study
Author(s) / Creator(s)
Molla, Hanna
Abstract / Description
Dataset for: de Wit, H., Molla, H. M., Bershad, A., Bremmer, M., & Lee, R. (2022). Repeated low doses of LSD in healthy adults: A placebo‐controlled, dose–response study. Addiction Biology, 27(2). https://doi.org/10.1111/adb.13143
The resurgence of interest in using psychedelic drugs, including lysergic acid diethylamide (LSD), in psychiatry has drawn attention to the medically unsupervised practice of ‘microdosing’. Thousands of users claim that very low doses of LSD, taken at 3–4-day intervals, improve mood and cognitive function., However, few controlled studies have described the effects of the drug when taken in this way. Here, in a double-blind controlled study, we studied the effects of four repeated doses of LSD tartrate (13 or 26 μg) or placebo, administered to healthy adults at 3–4 day intervals, on mood, cognitive performance and responses to emotional tasks. Participants were randomly assigned to one of three drug conditions: placebo (N = 18), 13 μg LSD (N = 19), or 26 μg LSD (N = 19). They attended four 5-hour drug-administration sessions separated by 3–4 days, followed by a drug-free follow-up session 3–4 days after the last session. LSD (26 μg) produced modest subjective effects including increased ratings of ‘feeling a drug effect’ and both stimulant-like and LSD-like effects, but the drug did not improve mood or affect performance on psychomotor or most emotional tasks. No residual effects were detected on mood or task performance on the drug-free follow-up session. We conclude that within the context of a controlled setting and a limited number of administrations, repeated low doses of LSD are safe, but produce negligible changes in mood or cognition in healthy volunteers.
Keyword(s)
behavior cognition LSD microdosing mood psychopharmacologyPersistent Identifier
Date of first publication
2021-10-12
Publisher
PsychArchives
Is referenced by
Citation
Molla, H. (2021). Dataset for: Repeated low doses of LSD in healthy adults: A placebo-controlled, dose-response study [Data set]. PsychArchives. https://doi.org/10.23668/PSYCHARCHIVES.5153
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There are no other versions of this object.
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Author(s) / Creator(s)Molla, Hanna
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PsychArchives acquisition timestamp2021-10-12T06:15:30Z
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Made available on2021-10-12T06:15:30Z
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Date of first publication2021-10-12
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Abstract / DescriptionDataset for: de Wit, H., Molla, H. M., Bershad, A., Bremmer, M., & Lee, R. (2022). Repeated low doses of LSD in healthy adults: A placebo‐controlled, dose–response study. Addiction Biology, 27(2). https://doi.org/10.1111/adb.13143en
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Abstract / DescriptionThe resurgence of interest in using psychedelic drugs, including lysergic acid diethylamide (LSD), in psychiatry has drawn attention to the medically unsupervised practice of ‘microdosing’. Thousands of users claim that very low doses of LSD, taken at 3–4-day intervals, improve mood and cognitive function., However, few controlled studies have described the effects of the drug when taken in this way. Here, in a double-blind controlled study, we studied the effects of four repeated doses of LSD tartrate (13 or 26 μg) or placebo, administered to healthy adults at 3–4 day intervals, on mood, cognitive performance and responses to emotional tasks. Participants were randomly assigned to one of three drug conditions: placebo (N = 18), 13 μg LSD (N = 19), or 26 μg LSD (N = 19). They attended four 5-hour drug-administration sessions separated by 3–4 days, followed by a drug-free follow-up session 3–4 days after the last session. LSD (26 μg) produced modest subjective effects including increased ratings of ‘feeling a drug effect’ and both stimulant-like and LSD-like effects, but the drug did not improve mood or affect performance on psychomotor or most emotional tasks. No residual effects were detected on mood or task performance on the drug-free follow-up session. We conclude that within the context of a controlled setting and a limited number of administrations, repeated low doses of LSD are safe, but produce negligible changes in mood or cognition in healthy volunteers.en
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Review statusunknown
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SponsorshipNational Institute on Drug Abuse. Grant Number: DA02812 / University of Chicago Medical Scientist Training program / National Institute of Health/National Institute of General Medical Sciences. Grant Number: T32GM007019 / Institute of Translational Medicine at the University of Chicago. Grant Number: UL1 RR024999en
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CitationMolla, H. (2021). Dataset for: Repeated low doses of LSD in healthy adults: A placebo-controlled, dose-response study [Data set]. PsychArchives. https://doi.org/10.23668/PSYCHARCHIVES.5153en
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Persistent Identifierhttps://hdl.handle.net/20.500.12034/4571
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Persistent Identifierhttps://doi.org/10.23668/psycharchives.5153
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Language of contenteng
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PublisherPsychArchives
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Is referenced byhttps://doi.org/10.1111/adb.13143
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Is related tohttps://doi.org/10.1111/adb.13143
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Keyword(s)behavioren
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Keyword(s)cognitionen
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Keyword(s)LSDen
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Keyword(s)microdosingen
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Keyword(s)mooden
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Keyword(s)psychopharmacologyen
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Dewey Decimal Classification number(s)150
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TitleDataset for: Repeated low doses of LSD in healthy adults: A placebo-controlled, dose-response studyen
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DRO typeresearchData