A Rare Fragile Site on Chromosome Requiring Bromodeoxyuridine for Expression in a Childhood Population

Takeshi Aoi; Takateru Okada; Kiminobu Minagawa

doi:10.2302/kjm.37.177

Takeshi Aoi, Takateru Okada, Kiminobu Minagawa

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Keywords: heritable fragile site, BrdU requiring fragile site, fra(10)(q25), chromosome 10

JOURNAL FREE ACCESS

1988 Volume 37 Issue 2 Pages 177-182

DOI https://doi.org/10.2302/kjm.37.177

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Abstract

This study deals with the first preliminary survey on a childhood population in Japan for rare (heritable) chromosome fragile site requiring bromodeoxyuridine (BrdU) in the culture medium for expression. A 12-year-old girl with BrdU requiring chromatid-type fragile site at 10q25 has been detected in a heterozygous fashion among 32 children who have no phenotypical abnormality.

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