Vojnosanitetski pregled 2022 Volume 79, Issue 12, Pages: 1233-1238
https://doi.org/10.2298/VSP200428001M
Full text (
313 KB)
Cited by
Trabeculectomy with mitomycin C for glaucoma secondary to emulsified silicone oil after pars plana vitrectomy: three-years follow up
Marjanović Ivan 
(University Clinical Center of Serbia, Eye Clinic, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, Serbia), Ivanmarjanovic007@gmail.com
Gvozdenović Ranko (University Clinical Center of Serbia, Eye Clinic, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, Serbia)
Božić Marija (University Clinical Center of Serbia, Eye Clinic, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, Serbia)
Marić Vesna (University Clinical Center of Serbia, Eye Clinic, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, Serbia)
Stojković Milenko (University Clinical Center of Serbia, Eye Clinic, Belgrade, Serbia + University of Belgrade, Faculty of Medicine, Belgrade, Serbia)
Marjanović Marija (University of Belgrade, Faculty of Medicine, Belgrade, Serbia + University Clinical Center of Serbia, Cardiology Clinic, Belgrade, Serbia)
Jordanova Elena (Clinical Hospital Center Zemun, Clinic for Internal Medicine, Department of Nephrology, Belgrade, Serbia)
Martinez Antonio (Clinical Research Department, Science Research and Sports, Ames, La Coruna, Spain)
Background/Aim. Different surgical interventions have been proposed, including trabeculectomy associated with antiproliferative agents because silicone oil (SO) removal cannot necessarily provide intraocular pressure (IOP) control. The aim of the study was to determine the efficacy of trabeculectomy with mitomycin C (MMC) for lowering IOP in patients with open-angle glaucoma (OAG) secondary to emulsified SO after pars plana vitrectomy. Methods. A single-center, prospective study was conducted, from December 2014 to December 2019, on 56 consecutive patients with an uncontrolled elevation of IOP after SO removal who were subjected to trabeculectomy with mitomycin MMC in that period. The primary end-point was the IOP at the three-year follow-up visit. Complete surgical success was defined as an IOP ranging from 7 mmHg to 18 mmHg without glaucoma medication. Qualified success was defined a s I OP ≤ 2 1 m mHg with one or two topical medications. Results. Fifty-six patients with a mean age of 5 3.6 [standard deviation (SD)15.5] years had a mean baseline IOP of 42.3 (39.3 to 45.3) mmHg, which reduced to 18.6 (17.9 to 19.3) mmHg three years after surgery (p < 0.0001). Seventeen (30.4%) eyes were classified as a complete success, 21 (37,5%) as a qualified success, and 18 (32.1%) as a failure. In all successfully treated patients, the number of antiglaucoma medications was significantly reduced from 2.85 (SD 0.77) to 1.63 (SD 0.62), p < 0.0001. Conclusion. Trabeculectomy with MMC may be an option for lowering IOP in patients with OAG secondary to emulsified SO after pars plana vitrectomy, which was not controlled with maximum
Keywords: glaucoma, open-angle, mitomycin, ophthalmologic surgical procedures, silicone oils, trabeculectomy
Show references
Karel I, Kalvodová B. Long-term results of pars plana vitrectomy and silicone oil for complications of diabetic retinopathy. Eur J Ophthalmol 1994; 4(1): 52-8.
Castellarin A, Grigorian R, Bhagat N, Del Priore L, Zarbin MA. Vitrectomy with silicone oil infusion in severe diabetic retinopathy. Br J Ophthalmol 2003; 87(3): 318-21.
Cibis PA, Becker B, Okun E, Canaan S. The use of liquid silicone in retinal detachment surgery. Arch Ophthalmol 1962; 68: 590-9.
Engelmann K, Becker KA. Heavy silicone oil endotamponade--a useful alternative to conventional endotamponade. Klin Monbl Augenheilkd 2009; 226(9): 699-704. (German)
Romano MR, Angi M, Romano V, Parmeggiani F, Campa C, Valldeperas X, et al. Intraocular pressure changes following the use of silicone oil or densiron 68 as endotamponade in pars plana vitrectomy. Clin Ophthalmol 2010; 4: 1391-6.
Schwartz SG, Flynn HW Jr, Lee WH, Wang X. Tamponade in surgery for retinal detachment associated with proliferative vit-reoretinopathy. Cochrane Database Syst Rev. 2014; 2(2): CD006126.
Miller JB, Papakostas TD, Vavvas DG. Complications of emulsified silicone oil after retinal detachment repair. Semin Ophthalmol 2014; 29(5-6): 312-8.
Grzybowski A, Pieczynski J, Ascaso FJ. Neuronal complications of intravitreal silicone oil: an updated review. Acta Ophthalmol 2014; 92(3): 201-4.
Alkin Z, Satana B, Ozkaya A, Basarir B, Altan C, Yazici AT, et al. Selective laser trabeculoplasty for glaucoma secondary to emulsified silicone oil after pars plana vitrectomy: a pilot study. Biomed Res Int 2014; 2014: 469163.
Ichhpujani P, Jindal A, Jay Katz L. Silicone oil induced glaucoma: a review. Graefes Arch Clin Exp Ophthalmol 2009; 247(12): 1585-93.
Mangouritsas G, Mourtzoukos S, Portaliou DM, Georgopoulos VI, Dimopoulou A, Feretis E. Glaucoma associated with the management of rhegmatogenous retinal detachment. Clin Ophthalmol 2013; 7: 727-34.
Errico D, Scrimieri FL, Riccardi R, Iarossi G. Trabeculectomy Versus ExPress Glaucoma Filtration Device in Silicomacro-phagocytic Open Angle Glaucoma Secondary to Silicone Oil Emulsification. Middle East Afr J Ophthalmol 2016; 23(2): 177-82.
Gupta S, Chaurasia AK, Chawla R, Kapoor KS, Mahalingam K, Swamy DR, et al. Long-term outcomes of glaucoma drainage devices for glaucoma post-vitreoretinal surgery with silicone oil insertion: a prospective evaluation. Graefes Arch Clin Exp Ophthalmol 2016; 254(12): 2449-54.
El-Saied HM, Abdelhakim MASE. Different surgical modalities for management of persistent glaucoma after silicone oil removal in vitrectomized eyes: One Year Comparative Study. Retina. 2017 Aug; 37(8):1535-1543.
Singh D, Chandra A, Sihota R, Kumar S, Gupta V. Long-term success of mitomycin-augmented trabeculectomy for glaucoma after vitreoretinal surgery with silicone oil insertion: a prospective case series. Retina 2014; 34(1): 123-8.
Honavar SG, Goyal M, Majji AB, Sen PK, Naduvilath T, Dandona L. Glaucoma after pars plana vitrectomy and silicone oil injection for complicated retinal detachments. Ophthalmology 1999; 106(1): 169-76; discussion 177.
Marjanovic IS, Marjanovic M, Kontic D, Markovic V, Bozic M, Maric V, et al. Trabeculectomy with mmc for glaucoma secondary to emulsified silicone oil after pars plana vitrectomy: one year follow up. DOG Congress 2016 “Ophthalmology - a big subject; Berlin; 2016 September 29 - 2016 October 2; Abstracts. Ophthalmologe 2016; 113 Suppl 2; 9.
Cabourne E, Clarke JC, Schlottmann PG, Evans JR. Mitomycin C versus 5-Fluorouracil for wound healing in glaucoma surgery. Cochrane Database Syst Rev 2015; 2015(11): CD006259.
Al Habash A, Aljasim LA, Owaidhah O, Edward DP. A review of the efficacy of mitomycin C in glaucoma filtration surgery. Clin Ophthalmol 2015; 9: 1945-51.
Clement CI, Goldberg I. The management of complicated glaucoma. Indian J Ophthalmol 2011; 59(Suppl 1): S141-7.
Chan CK, Tarasewicz DG, Lin SG. Subconjunctival migration of silicone oil through a Baerveldt pars plana glaucoma implant. Br J Ophthalmol 2005; 89(2): 240-1.