Vojnosanitetski pregled 2012 Volume 69, Issue 9, Pages: 771-777
https://doi.org/10.2298/VSP1209771P
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Association between chronic periodontitis and serum lipid levels
Pejčić Ana (Odeljenje za parodontologiju i oralnu medicinu, Niška Banja)
Kesić Ljiljana (Odeljenje za parodontologiju i oralnu medicinu, Niška Banja)
Ilić Stevan (Institut za lečenje i rehabilitaciju kardiovaskularnih bolesti, Niška Banja)
Pešić Zoran (Odeljenje za maksilofacijalnu hirurgiju, Medicinski fakultet, Niš)
Mirković Dimitrije (Medicinski fakultet, Klinika za stomatologiju, Niš)
Background/Aim. Periodontitis is a local inflammatory process mediating
destruction of periodontal tissues triggered by bacterial insult. However,
this disease is also characterized by systemic inflammatory host responses
that may contrbute, in part, to the recently reported increased risk for
systemic diseases, including an altered lipid metabolism. On the other hand,
many people in the world are affected by hyperlipidemia, which is a known
risk faktor for atherosclerosis. The aim of this study was to determine the
relationship between periodontal disease and blood lipid levels. Methods. A
total of 50 patients with periodontitis included in this study had no
documented history of recent acute coronary events. The healthy,
non-periodontal subjects (comparison group) comprised 25 subjects. All the
patients were periodontology examined and completed a medical history. Dental
plaque index, probing depth, gingival index bleeding on probing and clinical
attechment levels were recorded. Blood samples were taken on admission for
measurements of serum total cholesterol, triglycerides, hight density
lipoprotein cholesterol (HDL-cholesterol), and low density lipoprotein
cholesterol (LDL-cholesterol). Results. The obtained results showed that mean
levels of cholesterol (6.09 ± 1.61 mmol/L), triglycerdes (2.19+1.67mmol/l)
and LDL cholesterol (4.09 ± 1.40 mmol/L) in individuals with periodontitis
were higer, and levels od HDL (1.43 ± 0.51 mmol/L) was lower than those of
individuals without periodontitis (4.86 ± 1.37; 1.14 ± 0.71; 3.18 ± 0.64;
1.53 ± 0.32 mmol/L, respectively). Conclusion. This study confirms a
significant relationship between periodontal disease, regardless its
intensity, and blood lipid levels in the studied population. The results
imply that periodontitis may be a risk factor and may contribute to the
pathogenesis of atherosclerosis and cardiovascular diseases (CVD). However,
future prospective randomized studies have to determine whether periodontal
disease is a risk factor for the occurrence of CVD.
Keywords: periodontal diseases, risk assessment, hyperlipidemias, risk factors, triglycerides, cholesterol, hdl, cholesterol, ldl, periodontal index