doiSerbia

Redox parameters in blood of thyroid cancer patients after the radioiodine ablation

Spasojević-Tišma Vera D. (Public Company Nuclear Facilities of Serbia, Belgrade)
Matović Milovan D. (Faculty of Medical Sciences, Department of Nuclear Medicine, Kragujevac + Clinical Center Kragujevac, Department of Nuclear Medicine, Kragujevac)
Mihaljević Olgica B. (Faculty of Medical Sciences, Department of Pathophysiology, Kragujevac)
Živančević-Simonović Snežana T. (Faculty of Medical Sciences, Department of Pathophysiology, Kragujevac)
Jeremić Marija Ž. (Clinical Center Kragujevac, Department of Nuclear Medicine, Kragujevac)
Jakovljević Vladimir Lj. (Faculty of Medical Sciences, Department of Physiology, Kragujevac + I.E. Sechenov First Medical University, Department of Human Pathology, Moscow, Russia)
Todorović Vera N. (Faculty of Stomatology, Pancevo)
Pavlović Ivan Lj. (Vinča Institute of Nuclear Sciences, Laboratory of Molecular Biology and Endocrinology, Belgrade)
Pejić Snežana A. (Vinča Institute of Nuclear Sciences, Laboratory of Molecular Biology and Endocrinology, Belgrade)
Todorović Ana U. (Vinča Institute of Nuclear Sciences, Laboratory of Molecular Biology and Endocrinology, Belgrade)

The radioactive iodine (131I) ablation is a well-accepted treatment modality for differentiated thyroid cancer patients. Unfortunately, the radiation induces the oxidative stress and damages cells and tissues, simultaneously activating the mechanisms of antioxidative defense. Since the mechanisms of those processes are not completely known, we wanted to examine the changes in the most important reactive oxygen species and antioxidative components, as well as their correlation and significance for lipid peroxidation. Our results showed that the level of thiobarbituric acid reactive substances was increased during the first 30 days after the radiotherapy. Among antioxidant components, superoxide dismutase was increased in the 3rd and 30th day; catalase in 7th and reduced glutathione in 3rd and 7th day after the radiotherapy. As regards the prooxidants, the reduction of hydrogen peroxide (H2O2) was recorded in 7th and 30th day, and superoxide anion radical (O×-) was unchanged after the exposure to 131I. These results indicate that differentiated thyroid cancer patients are under constant oxidative stress despite the observed increase in antioxidative and reduction in prooxidative parameters. The understanding of these early processes is important since their progress determines the latter effects of 131I therapy.

Keywords: oxidative stress, antioxidant enzyme, lipid peroxidation, radiotherapy, thyroid cancer

Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. III41007 and Grant no. 175007