doiSerbia

The role of cellular development and cell death in neurochemical organization and integrative brain functions: Normal and pathological

Sherstnev Vladimir V. (Institut normalne fiziologije im. P.K. Anohina, Moskva)

In terms of systemic aspects of common molecular mechanisms of development, important part of which is the process of cellular death and integrative activity of nervous system, a omplex clinical-experimental study of effects of various neurotrophic and apoptotic factors (proteins S100b, HLDF, brain lectins CSL and R1) on learning and memory and ishemic stroke was performed. Data concerning specific and heterochronic participation of these factors in neurochemical mechanisms of learning and memory in mechanisms of ishemic stroke formation were established. Changes of examined factors and their antibodies as well as the dynamics of changes in sera and cerebro spinal fluid can be considered as prognostic markers of ischemic stroke and efficiency of therapy.

Keywords: neurochemistry, lectins, physiology, cell death, apoptosis, learning, memory, cerebrovascular accident