Journal of the Serbian Chemical Society 2007 Volume 72, Issue 5, Pages: 443-449
https://doi.org/10.2298/JSC0705443S
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Synthesis and antibacterial studies of some novel isoxazoline derivatives
Shah Tejaskumar (Department of Chemistry, B.K.M. Science College, State-Gujarat, India)
Desai Vikas (Department of Chemistry, B.K.M. Science College, State-Gujarat, India)
A series of 3-[3-(2,4-dichloro-5-fluorophenyl)-5-(2-furyl)-4,5-dihydro-1H-pyrazol- 1-yl]-5-(substituted phenyl/2-thienyl)isoxazolines (4a-j) were prepared. The structures of the isoxazoline derivatives were confirmed on the bases of elemental analysis and spectral data. The compounds were screened for their in vitro antibacterial activity using gram-positive bacteria and gram-negative bacteria.
Keywords: isoxazoline, chalcone, antibacterial activity, heterocyclic synthesis