doiSerbia

The impact of isatin derivatives on antibiotic production by Streptomyces hygroscopicus CH-7

Ćirić Jovan T. (Faculty of Technology, Leskovac)
Konstantinović Sandra S. (Faculty of Technology, Leskovac)
Ilić Slavica B. (Faculty of Technology, Leskovac)
Gojgić-Cvijović Gordana (ICTM, Department of Chemistry, Belgrade)
Savić Dragiša S. (Faculty of Technology, Leskovac)
Veljković Vlada B. (Faculty of Technology, Leskovac)

The effect of isatin derivatives as a nitrogen source on antibiotic (Hexaene H-85 and Azalomycine B) production by Streptomyces hygroscopicus CH-7 was studied. Isatin-3-hydrazone, 5-chloroisatin-3-hydrazone, isatin-3-tosylhydrazone, 5-chloroisatin-3-tosylhydrazone, isatin-3-(4`-hidroxy)benzoilhydrazone and 5-chloroisatin-3-(4`-hidroxy)benzoilhydrazone were synthesized in a crude glycerol, obtained during the biodiesel production from edible sunflower oil. The highest concentration of Hexaene H-85 is achieved with 5-chloroisatin-3-hydrazone (197 mg/cm3) in medium, while isatin-3-hydrazone has a greatest impact on Azalomycine B production (72 μg/cm3).

Keywords: isatin derivatives, Streptomyces hygroscopicus, Hexaene H-85, Azalomycine

Projekat Ministarstva nauke Republike Srbije, br. III 45001