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Protective effects of orally applied fullerenol nano particles in rats after a single dose of doxorubicin

Ičević Ivana Đ. (Department of Chemistry, Faculty of Science, Novi Sad)
Vukmirović Aleksandar N. (Department of Pharmacology and Toxicology, Medical Faculty, Novi Sad)
Srđenović Branislava U. (Department of Pharmacy, Medical Faculty, Novi Sad)
Suđi Jan J. (The Institute for the Health Protection of Workers Novi Sad, Novi Sad)
Đorđević Aleksandar N. (Department of Chemistry, Faculty of Science, Novi Sad)
Injac Rade M. (Institute of Pharmaceutical Biology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia)
Vasović Velibor M. (Department of Pharmacology and Toxicology, Medical Faculty, Novi Sad)

Polyhydroxylated, water soluble, fullerenol C60(OH)24 nano particles (FNP) in vitro and in vivo models, showed an expressive biological activity. The goal of this work was to investigate the potential protective effects of orally applied FNP on rats after a single dose of doxorubicin (DOX) (8 mg/kg (i.p.)) 6 h after the last application of FNP. After the last drug administration, the rats were sacrificed, and the blood and tissues were taken for the analysis. Biochemical and pathological results obtained in this study indicate that fullerenol (FNP), in H2O:DMSO (80:20, w/w) solution given orally in final doses of 10, 14.4, and 21.2 mg/kg three days successively, has the protective (hepatoprotective and nephroprotective) effect against doxorubicin-induced cytotoxicity via its antioxidant properties.

Keywords: fullerenol, nano particles, doxorubicine, in vivo, oral application