Facta universitatis - series: Physics, Chemistry and Technology 2022 Volume 20, Issue 1, Pages: 41-54
https://doi.org/10.2298/FUPCT2201041R
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Kinetic–spectrophotometric approach to the ampicillin hydrolytic degradation applied for the histidine determination
Rašić-Mišić Ivana D. 
(University of Niš, Faculty of Sciences and Mathematics, Department of Chemistry, Niš, Republic of Serbia), ivana.rasic@pmf.edu.rs
Tošić Snežana B. (University of Niš, Faculty of Sciences and Mathematics, Department of Chemistry, Niš, Republic of Serbia)
Pecev-Marinković Emilija T. (University of Niš, Faculty of Sciences and Mathematics, Department of Chemistry, Niš, Republic of Serbia)
Kostić Danijela A. (University of Niš, Faculty of Sciences and Mathematics, Department of Chemistry, Niš, Republic of Serbia)
Arsić Biljana B. (University of Niš, Faculty of Sciences and Mathematics, Department of Chemistry, Niš, Republic of Serbia)
The objective of this research was to develop a kinetic-spectrophotometric
method for the determination of microquantities of L-histidine in pure form
and dietary supplements. The method was based on the kinetics of ampicillin
degradation by Ni(II) ion as a catalyst in the presence of L-histidine in a
strongly alkaline medium. The rate of this reaction was monitored
spectrophotometrically by measuring the increase in absorbance at 265 nm as
a function of time. The same approach was used for the investigation of the
reaction rate in the absence of histidine. A differential variant of the
tangent method was used to process the kinetic data. Beer’s law was obeyed
in the interval of histidine concentration from 1.24 μg/ml to 11.63 μg/ml
with the relative standard deviation ranging from 8.1% to 0.7%. The
detection limit of 0.46 μg/ml was estimated based on the 3S0 criterion. The
interference effects of some metal ions, anions, and other molecules on the
reaction rate were studied to assess method selectivity. Herein described
method was applied for the quantification of histidine in dietary
supplements. The point hypothesis test confirmed that there was no
significant difference between the proposed and the reference method.
Keywords: ampicillin, hydrolytic degradation, Ni(II), L-histidine, activator
Project of the Serbian Ministry of Education, Science and Technological Development, Grant no. 451-03-68/2022-14/200124
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