doiSerbia

Non-susceptibility trends among methicillin-resistant coagulase-negative staphylococci isolated from blood cultures

Považan Anika (Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica + Medical Faculty, Novi Sad)
Vukelić Anka (Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia)
Kurucin Tatjana (Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia)
Hadnađev Mirjana (Institute for Pulmonary Diseases of Vojvodina, Sremska Kamenica, Serbia)
Milošević Vesna (Medical Faculty, Novi Sad)
Gusman Vera (Medical Faculty, Novi Sad)

Coagulase-negative staphylococci are a significant cause of hospital-acquired bacteremias. There is an increase of infections induced by methicillin-resistant strains, with growing resistance to other antibiotics. The aim of the study was to analyze the resistance of methicillin-resistant coagulase-negative staphylococci isolated from hemocultures in a five-year period. The study was carried out in the microbiology laboratory of the Institute for Pulmonary Diseases of Vojvodina, from 2008 to 2013. Coagulase-negative staphylococci were isolated from 196 hemocultures. Susceptibility tests were performed using the disc diffusion method. Of 196 coagulase-negative staphylococci, 122 (62.2%) were resistant to methicillin, of which 112 (91.8%), 105 (86.1%), 103 (84.4%), 88 (72.1%) were resistant to erythromycin, gentamicin, ciprofloxacin and clindamycin, respectively. All strains were susceptible to vancomycin and linezolid. Multiple resistance was registered in 100 (82%) strains. The most common resistance pattern was gentamicin-erythromycin-clindamycinciprofloxacin. Multiple resistance was established in a significant percentage of methicillin-resistant strains.

Keywords: Coagulase-negative staphylococci, methicillin-resistant, susceptibility, blood culture