Archives of Biological Sciences 2013 Volume 65, Issue 1, Pages: 65-70
https://doi.org/10.2298/ABS1301065M
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Antiproliferative effects of some medicinal plants on HeLa cells
Cenić-Milošević Desanka (Faculty of Stomatology, Pančevo)
Tambur Z. (Faculty of Stomatology, Pančevo + Military Medical Academy, Belgrade)
Bokonjić D. (Military Medical Academy, Belgrade)
Ivančajić S. (Faculty of Stomatology, Pančevo)
Stanojković Tatjana 
(Institute of Oncology and Radiology of Serbia, Belgrade)
Grozdanić Nadja (Institute of Oncology and Radiology of Serbia, Belgrade)
Juranić Zorica (Institute of Oncology and Radiology of Serbia, Belgrade)
Medicinal plants maintain the health and vitality of individuals, and also
have potential curative effect on various diseases, including cancer. In this
study were investigated the antiproliferative effects of water extracts of
previously obtained ethanolic dry extracts of three different medicinal
plants (Echinacea angustifolia, Salvia officinalis and Melissa officinalis)
on cell lines derived from human cervix adenocarcinoma (HeLa cells). The best
cytotoxic activity (IC50 = 43.52 μg/ml) on HeLa cell lines was exhibited by
Echinacea angustifolia. The extract of Salvia officinalis also showed a good
cytotoxic activity against HeLa cell lines; the IC50 value was 70.41 μg/ml.
Melissa officinalis manifested a slightly weaker cytotoxic activity and an
IC50 value of 122.22 μg/ml.
Keywords: Antiproliferative effect, Echinacea angustifolia, Salvia officinalis, Melissa officinalis
Projekat Ministarstva nauke Republike Srbije,
br. 34021 i br. 175011