| 마우스의 소화기관에서의 Caveolin-1 의 발현 |
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장석원1, 안미정2 |
1제주대학교 수의과대학 수의해부학교실
2제주대학교 의학전문대학원 해부학교실 |
| Expression of caveolin-1 in the digestive organs of mouse |
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Sukwon Jang1, Meejung Ahn2 |
1Department of Veterinary Anatomy, Jeju National University college of Veterinary Medicinine, Jeju, Korea
2Department of Anatomy, Jeju National University School of Medicine, Jeju, Korea |
Correspondence:
Meejung Ahn, Email: healthy@jejunu.ac.kr
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| Abstract |
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The expression of caveolin-1 in the digestive organ of mouse. Western blot analysis showed that caveolin-1 was expressed in the digestive organs with varying intensities. Caveolin-1 expression was low in the pancreas and stomach moderate in the Iiver and esophagus and high in the ileum, cecum and colon. Histologically, caveolin-1 was immunostained blood vessel endothelial cells inall digestive organs. ln the Iiver, caveolin-1 immunoreactivity was found in vascular endothelial cells and bile duct cells, but not in hepalocyles. In the pancreas, caveolin-1 was found in the Islet of Langerhans, but not in exocrine cells. Caveolin-1 was detected in some cells in the lamina propria of the esophagus, stomach, small intestine (ileum), cecum and large intestine (colon), occasionally in covering epithelial cells weakly. The immunoreactivity of caveolin-1 largely matched the results obtained with Western blot analysis. This is the first report showing the expression of caveolin-1 in the digestive organs of mouse. The present findings suggest that caveolin-1 was expressed in all digestive tissues with varying intensities. Caveolin-1 may play an important role in each digestive organ with the signal transduction pathway. The determination of their precise role in the digestive organs will require further study. |
| Key Words:
Caveolin; immunohistochemistry; Balb/c mouse; Digestive organ |
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