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Surfactant Complex Binding to DNA Interaction Study: Controlling Hydrophobicity in β-Cyclodextrin–DNA Binding Reactions

Karuppiah Nagaraj*1Pakkirisamy Muthukumaran2 Gunasekaran Gladwin3
Published 31-12-2020

DOI

https://doi.org/10.22573/spg.ijals.020.s122000102

AUTHOR AFFILIATION

1 Department of Chemistry, DMI-St-Eugene University, Lusaka, Zambia
2 Department of Biochemistry, DMI-St-Eugene University, Lusaka, Zambia
3 Department of Mathematics, DMI-St-Eugene University, Lusaka, Zambia

ABSTRACT

The interaction of cis-[Co(phen)2(TA)2](ClO4)3, a cationic surfactant complex (phen = 1-10 phenanthroline, TA= Tetradecylamine), with calf thymus DNA has been studied by physici-chemical techniques. The spectroscopic studies together with cyclic voltammetry and viscosity experiments support that the surfactant-cobalt(III) complex binds to calf thymus DNA (CT DNA) by intercalation through the aliphatic chain present in the complex into the base pairs of DNA. The presence of phenanthroline ligand with larger -frame work may also enhance intercalation. Besides the effect of binding of surfactant cobalt(III) complex to DNA in presence of -cyclodextrin has also studied. In presence of -cyclodextrin the binding occur through surface and (or) groove binding. The complex was investigated as one of the potential selective anticancer prodrugs. The complex was tested in vitro on human monolayer tumour cell lines: HepG2 (Human hepatocellular liver carcinoma) also.

Surfactant chain 2 Scheme 1. Surfactant chain buried into the cavity of b-Cyclodextrin img3 Img4  
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ARTICLE HISTORY

Received: July 2020 / Accepted: Nov 2020 / Published: Dec 2020

COPYRIGHT

© 2020 Nagaraj, K.,  et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/),whiich permits unrestricted use, distribution, and reproduction in any medium, provided the Original work is properly cited.

COMPETING INTERESTS

The authors have declared that no competing interests exist.

HOW TO CITE THIS ARTICLE

Nagaraj, K., Muthukumaran, P., & Gladwin, G. (2020). Surfactant Complex Binding to DNA Interaction Study: Controlling Hydrophobicity in β-Cyclodextrin–DNA Binding Reactions. Int J Agric Life Sci, 6(4), 318-332. doi: 10.22573/spg.ijals.020.s122000102


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