Vol. 9, Issue 3 (2020)

Author(s):
Chintapalli Gowri Sankar, Snigdharani Behera, Sruti Ranjan Mishra, Somesu M, Kiran Kumar B and Kirtimaya Mishra

Abstract:
In recent years oral dosage form for gastric retention (floating drug delivery systems) has drawn increasingly more consideration for their theoretical convenience in permitting control over time and site of drug release. The present study intended to develop floating microspheres of Ranitidine HCL, which belong to the class of Histsamine2 blockers. Floating microspheres Ranitidine HCL was prepared by the emulsion solvent evaporation method using HPMC K15M and ethylcellulose as polymer. Six different formulations were developed. The floating microsphere was assessed for the angle of repose, particle size, percentage yield, in vitro lightness, manifestation efficiency, drug-polymer compatibility (IR-study), scanning electron microscopy, drug release and DSC (Differential Scanning Colorimetry), X-Ray Diffraction (XRD) of the microsphere. The outcome of the experiment shows that as the concentration of polymer influences its result the particle size, percentage yield, in vitro buoyancy and drug release of the microsphere. Formulations produced with HPMC K15M exhibited superb Micromeritic properties, percentage yield, in vitro buoyancy, manifestation efficiency, and percentage drug release when contrasted with ethylcellulose polymer. Consequences of our present study propose that the floating microsphere of Ranitidine HCL can be effectively intended to develop controlled drug delivery which can lessen dosing recurrence thus this formulation can be considered as an alternative to conventional dosage forms.