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Efficacy and safety of opioid therapy guided by pharmacogenetics: a systematic review

    Federico Rodriguez Cairoli

    *Author for correspondence:

    E-mail Address: fcairoli@iecs.org.ar

    Instituto de Efectividad Clínica y Sanitaria (IECS), Dr. Emilio Ravignani, Buenos Aires, 2024 (C1014CPV), Argentina

    Neuropsychopharmacology Unit, Pharmacology Division, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Buenos Aires, Argentina

    ,
    Francisco Appiani

    Neuropsychopharmacology Unit, Pharmacology Division, Hospital de Clínicas José de San Martín, Universidad de Buenos Aires, Buenos Aires, Argentina

    ,
    Juan Manuel Sambade

    Servicio de Clínica Médica, Hospital “Prof. Dr. Bernardo Houssay” Asociado a la Universidad de Buenos Aires, Municipalidad de Vicente Lopez, Buenos Aires, Argentina.

    ,
    Daniel Comandé

    Instituto de Efectividad Clínica y Sanitaria (IECS), Dr. Emilio Ravignani, Buenos Aires, 2024 (C1014CPV), Argentina

    ,
    Lina Camacho Arteaga

    Department of Clinical Pharmacology, University Hospital Hall d’ Hebron, Barcelona, Spain

    &
    Agustín Ciapponi

    Instituto de Efectividad Clínica y Sanitaria (IECS), Dr. Emilio Ravignani, Buenos Aires, 2024 (C1014CPV), Argentina

    Published Online:https://doi.org/10.2217/pgs-2021-0021

    Aim: To perform a systematic review to determine the efficacy/safety of PGx-guided opioid therapy for chronic/postoperative pain. Materials & methods: We searched PubMed and other specialized databases. Articles were considered if they compared the efficacy/safety of PGx-guided opioid therapy versus usual care. The risk of bias assessment was performed using Cochrane tools. Results: A total of 3794 records were retrieved. Only five were included for data extraction. A lower requirement of analgesics during postoperative in the PGx-guided intervention arm was reported in two studies. Also, two studies reported significant pain improvement in favor of the PGx-guided therapy when analyzing the subgroup of patients with a high-risk CYP2D6 phenotype. Conclusion: Despite the findings described, information on the efficacy/safety of this intervention is scarce.

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