Controlled Release of Amoxicillin from Bis(2-hydroxyethyl)amine Functionalized SBA-15 as a Mesoporous Sieve Carrier
Subject Areas : Journal of Chemical Health Risks
Nafiseh
Yaghobi
1
(Department of Chemistry, Yadegar -e- Imam Khomeini (RAH) Shahre Rey Branch, Islamic Azad University, Tehran, Iran)
Leila
Hajiaghababaei
2
(Department of Chemistry, Yadegar-e-Imam Khomeini (RAH) Shahre-rey Branch, Islamic Azad University, Tehran, Iran)
Alireza
Badiei
3
(School of Chemistry, College of Science, University of Tehran, Tehran, Iran)
Mohammad Reza
Ganjali
4
(Center of Excellence in Electrochemistry, School of Chemistry, College of Science, University of Tehran, Tehran, Iran)
Ghodsi
Mohammadi Ziarani
5
(Department of Chemistry, Alzahra University, Tehran, Iran)
Keywords: Drug delivery, Amoxicillin, Bis (2- hydroxy ethyl) amine functionalized mesoporous SBA-15, Controlled release,
Abstract :
In this study, Bis (2-hydroxyethyl)amine functionalized mesoporous SBA-15 was synthesized for utilization in amoxicillin drug-delivery. Amoxicillin could absorb on the prepared functionalized SBA-15. A solution of amoxicillin in a suitable solvent was used for this purpose. Amoxicillin molecules release from the matrix into a simulated body fluid (SBF) solution, and phosphate buffers were studied. UV-Vis spectrophotometric method was chosen for amoxicillin determination. Thermogravimetric analysis (TGA), scanning electron microscopy (SEM), nitrogen adsorption–desorption, and powder X-ray diffraction (XRD) technique were applied for characterization of the synthesized materials. The best loading of amoxicillin was done at pH 8.5 after stirring for 30 minutes. The results showed that, at lower pH, releasing of the drug was done faster than it at higher pH. Also, the average release rate of amoxicillin in the body fluid samples that were simulated was about 7 µg h-1. A highly slow release pattern was observed. The proposed material can be used for enhancing the medical impact of amoxicillin and carrying amoxicillin.
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