The three barbituric acid derivatives were found to be effective as polymerization initiators instead of using Benzoylperoxide-tertAmine. Of the three derivatives, 1-Cyclohexyl-5-ethyl barbituric acid (CEBA) was the most effective for the HAZE value. The setting time was the fastest at 1.0 phr of CEBA. The optimum content of Acetylacetone copper (ACu) was 10ppm. The higher the content of ACu, the faster the setting time and the more bluish the color of the cured specimens. The lower the content of ACu, the slower the setting time. Dilauryl dimethyl ammonium chloride (LMAC) was more effective for the setting time, but the setting time was not significantly different due to the content of LMAC as determined by ANOVA. The residual monomer content of the cured self-curing resin using new initiator (Ba-Cl-Cu) in acetone and water was higher than for the conventional resin (BP0-tertAmine). To reduce the residual monomer, the cured specimen should be immersed in water for at least 1 hour prior to oral insertion.