A study was performed on the role of glutathione during Poisoning caused by organophosphoric agricultural chem icals (alkylphosphates) and on the mechanism of glutathione in human blood, dinically and experimentally also.
The value of glutathione inblood was measured by Alloxan 305method.
The results obtained can besummarized as follows.
1) The value of total gultathione in blood was40.80±2.09mg/dl in healthy persons, 37.80±1.26mg/dl in acute poisoning of parathione and 38.7 0±1.26mg/dl in chronic poisning of it.
2) Treatment of acute parathione poisoning with glutathione (600mg a day, for two daysi.v.) was effective from the view-pojnt of the increase of serum ChE activity.
3) Treatment of chronic parathione poisoning with glutathione (300mg a day, for 4 weeks oral) was veryeffective from the view-point of serum ChE activity.
4) Mechanism of gultathione during poisoning of organophosphoric agricultural chemicals was researched clinically and experimentally. From the results of them, the value of total gultathione and serum ChE showed the rapid increase in blood by an intravenous injection of gultathione, but not such increase by mouth even after 120 minutes.
5) From the investigation in time course after given by i.v.or mouth, gultathione, taken into blood, was foundrather in blood cell than serum, specially by an intravenous injection of it.