Neurointensive Care of Traumatic Brain Injury Patients Based on Coagulation and Fibrinolytic Parameter Monitoring

Ryuta NAKAE; Yasuo MURAI; Yasuhiro TAKAYAMA; Kaoru NAMATAME; Yoshiyuki MATSUMOTO; Takahiro KANAYA; Yu FUJIKI; Hidetaka ONDA; Go SUZUKI; Junya KANEKO; Takashi ARAKI; Yasutaka NAOE; Hidetaka SATO; Kyoko UNEMOTO; Akio MORITA; Hiroyuki YOKOTA; Shoji YOKOBORI

doi:10.2176/jns-nmc.2022-0226

Special Topic

Neurointensive Care of Traumatic Brain Injury Patients Based on Coagulation and Fibrinolytic Parameter Monitoring

Ryuta NAKAE, Yasuo MURAI, Yasuhiro TAKAYAMA, Kaoru NAMATAME, Yoshiyuki MATSUMOTO, Takahiro KANAYA, Yu FUJIKI, Hidetaka ONDA, Go SUZUKI, Junya KANEKO, Takashi ARAKI, Yasutaka NAOE, Hidetaka SATO, Kyoko UNEMOTO, Akio MORITA, Hiroyuki YOKOTA, Shoji YOKOBORI

Author information

Ryuta NAKAE
Department of Emergency and Critical Care Medicine, Nippon Medical School
Yasuo MURAI
Department of Neurological Surgery, Nippon Medical School Hospital
Yasuhiro TAKAYAMA
Department of Emergency and Critical Care Medicine, Nippon Medical School
Kaoru NAMATAME
Department of Emergency and Critical Care Medicine, Nippon Medical School
Yoshiyuki MATSUMOTO
Department of Emergency and Critical Care Medicine, Nippon Medical School
Takahiro KANAYA
Department of Emergency and Critical Care Medicine, Nippon Medical School
Yu FUJIKI
Emergency and Critical Care Center, Kawaguchi Municipal Medical Center
Hidetaka ONDA
Department of Emergency and Critical Care Medicine, Nippon Medical School
Go SUZUKI
Emergency and Critical Care Center, Kawaguchi Municipal Medical Center
Junya KANEKO
Department of Emergency and Critical Care Medicine, Nippon Medical School
Takashi ARAKI
Department of Traumatology, Saitama Children's Medical Center
Yasutaka NAOE
Emergency and Critical Care Center, Kawaguchi Municipal Medical Center
Hidetaka SATO
Department of Emergency and Critical Care Medicine, Nippon Medical School
Kyoko UNEMOTO
Department of Emergency and Critical Care Medicine, Nippon Medical School
Akio MORITA
Department of Neurological Surgery, Nippon Medical School Hospital
Hiroyuki YOKOTA
Graduate School of Medical and Health Science, Nippon Sport Science University
Shoji YOKOBORI
Department of Emergency and Critical Care Medicine, Nippon Medical School

Keywords: traumatic brain injury, blood coagulation disorders, treatment, blood transfusion, surgery

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Supplementary material

2022 Volume 62 Issue 12 Pages 535-541

DOI https://doi.org/10.2176/jns-nmc.2022-0226

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Abstract

Coagulopathy, a common complication of traumatic brain injury (TBI), is characterized by a hypercoagulable state developing immediately after injury, with hyperfibrinolysis and bleeding tendency peaking 3 h after injury, followed by fibrinolysis shutdown. Reflecting this timeframe, the coagulation factor fibrinogen is first consumed and then degraded after TBI, its concentration rapidly decreasing by 3 h post-TBI. The fibrinolytic marker D-dimer reaches its maximum concentration at the same time. Hyperfibrinolysis in the acute phase of TBI is associated with poor prognosis via hematoma expansion. In the acute phase, the coagulation and fibrinolysis parameters must be monitored to determine the treatment strategy. The combination of D-dimer plasma level at admission and the level of consciousness upon arrival at the hospital can be used to predict the patients who will "talk and deteriorate." Fibrinogen and D-dimer levels should determine case selection and the amount of fresh frozen plasma required for transfusion. Surgery around 3 h after injury, when fibrinolysis and bleeding diathesis peak, should be avoided if possible. In recent years, attempts have been made to estimate the time of injury from the time course of coagulation and fibrinolysis parameter levels, which has been particularly useful in some cases of pediatric abusive head trauma patients.

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