1988 Volume 27 Issue 3 Pages 291-294
Serum pepsinogen 1, serum gastrin, ABO blood groups, secretor status of ABH blood group substances and behavioral factors were studied in 15 patients with duodenal ulcer and 6 1 their relatives affected and unaffected to duodenal ulcer. Duodenal ulcer patients had hyperpepsinogenemia 1 either with or without a positive family history of duodenal ulcer. Serum gastrin level was higher in duodenal ulcer patients and unaffected relatives with a positive family history of duodenal ulcer than those with a negative family history. Non secretor status was frequently observed in duodenal ulcer patients with a positive family history. There was no difference in behavioral factors between duodenal ulcer patients and unaffected relatives with a positive family history. It is concluded that genetically determined variables such as hyperpepsinogenemia 1 and non secretor status play an important role on the susceptibility to duodenal ulcer in subjects with a positive family history, and hypergastrinemia maybe subclinical marker of familial aggregation of duodenal ulcer.
