Interstitial Pneumonia with HLA-B54 Antigen that Responded Well to Erythromycin

Hiroshi Ishimoto; Noriho Sakamoto; Atsuko Hara; Takashi Kido; Hiroyuki Yamaguchi; Kazuko Yamamoto; Yasushi Obase; Yuji Ishimatsu; Hiroshi Mukae

doi:10.2169/internalmedicine.9304-21

CASE REPORTS

Interstitial Pneumonia with HLA-B54 Antigen that Responded Well to Erythromycin

Hiroshi Ishimoto, Noriho Sakamoto, Atsuko Hara, Takashi Kido, Hiroyuki Yamaguchi, Kazuko Yamamoto, Yasushi Obase, Yuji Ishimatsu, Hiroshi Mukae

Author information

Hiroshi Ishimoto
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Noriho Sakamoto
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Atsuko Hara
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Takashi Kido
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Hiroyuki Yamaguchi
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Kazuko Yamamoto
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Yasushi Obase
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan
Yuji Ishimatsu
Department of Nursing, Nagasaki University Graduate School of Biomedical Sciences, Japan
Hiroshi Mukae
Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan

Keywords: interstitial pneumonia, HLA-B54 antigen, diffuse panbronchiolitis, macrolide, erythromycin

JOURNAL OPEN ACCESS

2022 Volume 61 Issue 23 Pages 3559-3562

DOI https://doi.org/10.2169/internalmedicine.9304-21

Browse “Advance online publication” version

Details

Abstract

A 65-year-old Japanese man with interstitial pneumonia demonstrated honeycomb lung with thickened walls on chest high-resolution computed tomography (HRCT) and predominance of neutrophils in the cell fraction of the bronchoalveolar lavage fluid. Although there were no centrilobular nodular or branching shadows on chest HRCT suggestive of diffuse panbronchiolitis, he exhibited sinusitis and had the human leukocyte antigen (HLA)-B54 antigen. With long-term macrolide therapy, the cough and sputum production markedly improved, wall thickening of the honeycomb lung on chest HRCT decreased, and the forced vital capacity increased. Confirming the presence of HLA-B54 antigen may help determine the indication for long-term macrolide therapy in interstitial pneumonia patients.

Corresponding author

Register with J-STAGE for free!